2023
DOI: 10.1016/j.biotechadv.2023.108213
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Multivalent protein-drug conjugates – An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells

Natalia Porębska,
Krzysztof Ciura,
Aleksandra Chorążewska
et al.
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Cited by 12 publications
(3 citation statements)
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“…Points to consider when investigating this approach for drug delivery to cancer cells include the following: the specificity of the tumor target, whether the target is found on healthy cells, and is it the only or predominant moiety recognized by the binding protein; is it affected by the number of binding antibodies/number of receptors expressed on the surface of target cells; is the carrier taken up readily by tumor cells and the drug readily released within them; how long does the drug remain effective; are other cells affected by released drug; do patients that fall into different classifications of the cancer respond similarly; and how easily can the particles be made, purified, and transported. As of 2023, 14 antibody-drug combinations had received FDA approval, and many more protein-drug combinations are under investigation [165]. An example of this approach is the use of a humanized murine IgG4 anti-CD33 (siglec 3) antibody to target gemtuzumab ozogamicin (GO) in acute myeloid leukemia cells.…”
Section: Use and Possible Advantages Of Multivalency When Targeting B...mentioning
confidence: 99%
“…Points to consider when investigating this approach for drug delivery to cancer cells include the following: the specificity of the tumor target, whether the target is found on healthy cells, and is it the only or predominant moiety recognized by the binding protein; is it affected by the number of binding antibodies/number of receptors expressed on the surface of target cells; is the carrier taken up readily by tumor cells and the drug readily released within them; how long does the drug remain effective; are other cells affected by released drug; do patients that fall into different classifications of the cancer respond similarly; and how easily can the particles be made, purified, and transported. As of 2023, 14 antibody-drug combinations had received FDA approval, and many more protein-drug combinations are under investigation [165]. An example of this approach is the use of a humanized murine IgG4 anti-CD33 (siglec 3) antibody to target gemtuzumab ozogamicin (GO) in acute myeloid leukemia cells.…”
Section: Use and Possible Advantages Of Multivalency When Targeting B...mentioning
confidence: 99%
“…The evolution of ADCs has greatly expanded personalized tumor therapy, leveraging their unique structure for precise targeting and minimal off-target toxicity in ideal conditions. In the structural design of ADCs, the majority are either based on IgG design or created utilizing multivalent proteins [ 12 ], peptides [ 13 , 14 ], multi-structured fusion proteins [ 15 ], and other small-molecule proteins [ 16 ] or mini-peptides [ 11 ]. However, in actual clinical research, the bind site barrier is a pivotal impediment hindering the development of ADCs [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, developing thermoresponsive and multifunctional nanosystems is novel and propagatory towards nanobioapplications as well real real-time industrial usage. Until now, quantum dots (QDTs) [11][12][13][14][15], carbon nanotubes (CNTs) [16][17][18], nanowires, nanorods, coreshell nanoparticles, micelles, etc., have been reported to their kind but thermoresponsive and morphologically modifiable [(PLA)-b-(Car)] based 1) frustum shaped nanoparticles, 2) elliptical cone shaped nanoparticles and 3) dome-shaped nanoparticles with huge porosity is newer and interesting concept to evaluate the catalytic activity for biomedical regulations [19][20][21]. Consequently, Scheme 1 deliberates steps involved in the synthesis of [(PLA)-b-(Car)] followed by the design and development of different types of nanoparticles and their stimuliresponsive catalytic activity through the fluorescence measurement of [(Cys)-(Au + )] [22][23][24][25][26].…”
Section: Introductionmentioning
confidence: 99%