2019
DOI: 10.1021/jacs.8b12553
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Multivalent Recognition at Fluid Surfaces: The Interplay of Receptor Clustering and Superselectivity

Abstract: This is a repository copy of Multivalent recognition at fluid surfaces: the interplay of receptor clustering and superselectivity.

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Cited by 49 publications
(87 citation statements)
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References 44 publications
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“…Molecular aspects, such as the number of receptors involved in the interactions, the local receptor density and the lateral diffusion on the cell membrane, are critical factors playing a role in these phenomena. 5 To provide quantitative insight into these molecular parameters, it is necessary to build synthetic models that can mimic the biological interaction at the interface and in which parameters such as receptor density and surface uidity can be controlled and quantied.…”
Section: Introductionmentioning
confidence: 99%
“…Molecular aspects, such as the number of receptors involved in the interactions, the local receptor density and the lateral diffusion on the cell membrane, are critical factors playing a role in these phenomena. 5 To provide quantitative insight into these molecular parameters, it is necessary to build synthetic models that can mimic the biological interaction at the interface and in which parameters such as receptor density and surface uidity can be controlled and quantied.…”
Section: Introductionmentioning
confidence: 99%
“…The second term describes the attractive interaction between a given blob j and the surface, due to DNA base pairing between the genomic DNA and the DNA that is grafted to the surface. This model has been experimentally verified in a study of multivalent binding of hyaluronan HA-β-CD to receptor-coated surfaces (24,43). The model provided an accurate description of polymer-surface interactions including multivalent-binding effects; superselective response; and the dependence of binding on receptor interaction strength, valency, and concentration.…”
Section: Methodsmentioning
confidence: 90%
“…In this work, an analytical model was developed that provides quantitative predictions of the tuning of the superselective binding properties of the polymer, based on molecular characteristics such as affinity and valency. The effect of the ligand mobility at surfaces to the superselective binding was recently investigated . The binding of multivalent CD‐modified HA polymers was found to be enhanced and shifted to lower receptor densities at fluid interfaces (based on SLBs) compared to immobile ones (based on SAMs).…”
Section: Multivalent Studies At Functionalized Platformsmentioning
confidence: 99%