Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering

Huang, Yen Jang; Shiau, Ai‐Li; Chen, Shih-Yao; Chen, Yuh Ling; Wang, Chrong‐Reen; Tsai, Chiau Yuang; Chang, Meng-Wei; Li, Yuan Tsung; Leu, Chia Hsing; Wu, Chao‐Liang

doi:10.22203/ecm.v023a13

Cited by 44 publications

(26 citation statements)

References 32 publications

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“…GNP were recently proposed as a new treatment for arthritis and other rheumatic diseases due to their anti‐inflammatory properties . Pereira et al.…”

Section: Gold Nanoparticles For Ophthalmic Therapymentioning

confidence: 99%

Gold nanoparticles in ophthalmology

Masse

Ouellette

Lamoureux

et al. 2018

Medicinal Research Reviews

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Many research projects are underway to improve the diagnosis and therapy in ophthalmology. Indeed, visual acuity deficits affect 285 million people worldwide and different strategies are being developed to strengthen patient care. One of these strategies is the use of gold nanoparticles (GNP) for their multiple properties and their ability to be used as both diagnosis and therapy tools. This review exhaustively details research developing GNPs for use in ophthalmology. The toxicity of GNPs and their distribution in the eye are described through in vitro and in vivo studies. All publications addressing the pharmacokinetics of GNPs administered in the eye are extensively reviewed. In addition, their use as biosensors or for imaging with optical coherence tomography is illustrated. The future of GNPs for ophthalmic therapy is also discussed. GNPs can be used to deliver genes or drugs through different administration routes. Their antiangiogenic and anti-inflammatory properties are of great interest for different ocular pathologies. Finally, GNPs can be used to improve stereotactic radiosurgery, brachytherapy, and photothermal therapy because of their many properties.

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“…GNP were recently proposed as a new treatment for arthritis and other rheumatic diseases due to their anti‐inflammatory properties . Pereira et al.…”

Section: Gold Nanoparticles For Ophthalmic Therapymentioning

confidence: 99%

Gold nanoparticles in ophthalmology

Masse

Ouellette

Lamoureux

et al. 2018

Medicinal Research Reviews

View full text Add to dashboard Cite

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“…Cell receptors : potentially any non- or slowly internalizing cell surface antigen can be a target, such as CD45 (T-cell, B-cell, macrophage), 157 death receptor 4 (breast and colon cancers, etc. ), 158 prostate stem cell antigen (prostate cancer), 159 and carcinoembryonic antigen (many tumor types, but not on normal cells).…”

Section: Conclusion and Beyondmentioning

confidence: 99%

Drug-free macromolecular therapeutics – a new paradigm in polymeric nanomedicines

Chu

Kopeček

2015

Biomater. Sci.

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This review highlights a unique research area in polymer-based nanomedicine designs. Drug-free macromolecular therapeutics induce apoptosis of malignant cells by the crosslinking of surface non-internalizing receptors. The receptor crosslinking is mediated by the biorecognition of high-fidelity natural binding motifs (such as antiparallel coiled-coil peptides or complementary oligonucleotides) that are grafted to the side chains of polymers or attached to targeting moieties against cell receptors. This approach features the absence of low-molecular-weight cytotoxic compounds. Here, we summarize the rationales, different designs, and advantages of drug-free macromolecular therapeutics. Recent developments of novel therapeutic systems for B-cell lymphomas are discussed, as well as relevant approaches for other diseases. We conclude by pointing out various potential future directions in this exciting new field.

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“…Galectin-1, for example, is a multivalent carbohydrate binding protein that mediates the malignant cellular activities by cross-linking glycoproteins in the tumor microenvironment. Specifically, galectin-1 has been reported to be involved in multivalent mechanisms that cluster cell surface glycoproteins [ 8 , 9 ], cross-link receptors [ 10 , 11 ], and form lattices and larger aggregates [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Galectin-1 in Cancer Progression, and Synthetic Multivalent Systems for the Study of Galectin-1

Cousin

Cloninger

2016

IJMS

109

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This review discusses the role of galectin-1 in the tumor microenvironment. First, the structure and function of galectin-1 are discussed. Galectin-1, a member of the galectin family of lectins, is a functionally dimeric galactoside-binding protein. Although galectin-1 has both intracellular and extracellular functions, the defining carbohydrate-binding role occurs extracellularly. In this review, the extracellular roles of galectin-1 in cancer processes are discussed. In particular, the importance of multivalent interactions in galectin-1 mediated cellular processes is reviewed. Multivalent interactions involving galectin-1 in cellular adhesion, mobility and invasion, tumor-induced angiogenesis, and apoptosis are presented. Although the mechanisms of action of galectin-1 in these processes are still not well understood, the overexpression of galectin-1 in cancer progression indicates that the role of galectin-1 is significant. To conclude this review, synthetic frameworks that have been used to modulate galectin-1 processes are reviewed. Small molecule oligomers of carbohydrates, carbohydrate-functionalized pseudopolyrotaxanes, cyclodextrins, calixarenes, and glycodendrimers are presented. These synthetic multivalent systems serve as important tools for studying galectin-1 mediated cancer cellular functions.

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Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering

Cited by 44 publications

References 32 publications

Gold nanoparticles in ophthalmology

Gold nanoparticles in ophthalmology

Drug-free macromolecular therapeutics – a new paradigm in polymeric nanomedicines

The Role of Galectin-1 in Cancer Progression, and Synthetic Multivalent Systems for the Study of Galectin-1

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