Multivariable Response of Semiconductor Nanocrystal-Dye Sensors: The Case of pH

Krooswyk, Joel D.; Tyrakowski, Christina M.; Snee, Preston T.

doi:10.1021/jp1093096

Cited by 21 publications

(17 citation statements)

References 46 publications

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“…The blue-shift of the NC emission at low dye-loading levels is likely due to differential FRET efficiency across the NC emission profile as recently demonstrated; 47–48 furthermore, the blue-shift of the dye acceptor emission is due to the narrow excitation window from the NC donor. 49 …”

Section: Resultsmentioning

confidence: 99%

Energy transfer of CdSe/ZnS nanocrystals encapsulated with rhodamine-dye functionalized poly(acrylic acid)

Somers

Snee

Bawendi

et al. 2012

Journal of Photochemistry and Photobiology A: Chemistry

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Energy transfer between a CdSe/ZnS nanocrystal (NC) donor and a rhodamine isothiocyanate (RITC) acceptor has been achieved via a functionalized poly(acrylic acid) (PAA) encapsulating layer over the surface of the NC. The modification of PAA with both N-octylamine (OA) and 5-amino-1-pentanol (AP), [PAA-OA-AP], allows for the simultaneous water-solubilization and functionalization of the NCs, underscoring the ease of synthesizing NC-acceptor conjugates with this strategy. Photophysical studies of the NC-RITC constructs showed that energy transfer is efficient, with kFRET approaching 108 s−1. The ease of the covalent conjugation of molecules to NCs with PAA-OA-AP coating, together with efficient energy transfer, makes the NCs encapsulated with PAA-OA-AP attractive candidates for sensing applications.

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Section: Resultsmentioning

confidence: 99%

Energy transfer of CdSe/ZnS nanocrystals encapsulated with rhodamine-dye functionalized poly(acrylic acid)

Somers

Snee

Bawendi

et al. 2012

Journal of Photochemistry and Photobiology A: Chemistry

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“…[18–19] Several groups have exploited QD-based approaches to measure cellular pH. [20] Medintz et al reported that QD-dopamine conjugates were pH-responsive by the redox abilities of the conjugated dopamine dye (Figure 2). [20a] The surface of CdSe/ZnS QDs (λ em = 550 nm) were coated with hexahistidines that are covalently attached by dopamines.…”

Section: Cell-based Biosensorsmentioning

confidence: 99%

Quantum Dot–Dye Conjugates for Biosensing, Imaging, and Therapy

Jung

Chen

2018

Adv Healthcare Materials

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Adding value to the intrinsic properties of quantum dots (QDs), a strategy to conjugate dyes on the surface of QDs offers new opportunities, since the coupling between QD and dyes can be designed to allow Förster resonance energy transfer (FRET) and/or electron transfer (eT). These processes are accompanied by the change of QD and/or dye fluorescence and subsequent photochemical reactions (e.g., generation of O ). Based on the change of fluorescence signals by the interaction with biomolecules, QD-dye conjugates are exploited as biosensors for the detection of pH, O , nicotinamide adenine dinucleotide (phosphate), ions, proteases, glutathione, and microRNA. QD-dye conjugates also can be modulated by the irradiation of external light; this concept is demonstrated for fluorescence super-resolution imaging as photoactivatable or photoswitchable probes. When QDs are conjugated with photosensitizing dyes, the QD-dye conjugates can generate O in a repetitive manner for better cancer treatment, and can also be available for approaches using two-photon excitation or bioluminescence resonance energy transfer mechanisms for deep tissue imaging. Here, the recent advances in QD-dye conjugates, where FRET or eT produces fluorescence readouts or photochemical reactions, are reviewed. Various QD-dye conjugate systems and their biosensing/imaging and photodynamic therapeutics are summarized.

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“…Krooswyk et al [ 89 ] studied the response mechanism of this QD-sensing dye motif using a CdS/ZnS-fluorescein pH sensor. They initially proposed that the response mechanism should be dictated only by organic dye’s photochemical properties.…”

Section: The Response Mechanisms Of Qd-based Fret Sensors: Spectramentioning

confidence: 99%

QD-Based FRET Probes at a Glance

Shamirian

Ghai

Snee

2015

Sensors

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The unique optoelectronic properties of quantum dots (QDs) give them significant advantages over traditional organic dyes, not only as fluorescent labels for bioimaging, but also as emissive sensing probes. QD sensors that function via manipulation of fluorescent resonance energy transfer (FRET) are of special interest due to the multiple response mechanisms that may be utilized, which in turn imparts enhanced flexibility in their design. They may also function as ratiometric, or “color-changing” probes. In this review, we describe the fundamentals of FRET and provide examples of QD-FRET sensors as grouped by their response mechanisms such as link cleavage and structural rearrangement. An overview of early works, recent advances, and various models of QD-FRET sensors for the measurement of pH and oxygen, as well as the presence of metal ions and proteins such as enzymes, are also provided.

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Multivariable Response of Semiconductor Nanocrystal-Dye Sensors: The Case of pH

Cited by 21 publications

References 46 publications

Energy transfer of CdSe/ZnS nanocrystals encapsulated with rhodamine-dye functionalized poly(acrylic acid)

Energy transfer of CdSe/ZnS nanocrystals encapsulated with rhodamine-dye functionalized poly(acrylic acid)

Quantum Dot–Dye Conjugates for Biosensing, Imaging, and Therapy

QD-Based FRET Probes at a Glance

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