This study investigates the mechanical behavior and damage mechanisms of thin-walled glass/epoxy filament wound tubes under quasi-static lateral loads. The novelty is that the tubes are reinforced in critical areas using strip composite patches to provide a topology-optimized tube, and their damage mechanisms and mechanical performance are compared to that of un-reinforced (reference) tubes. To detect the types of damage mechanisms and their progression, the Acoustic Emission (AE) method is employed, accompanied by data clustering analysis. The loading conditions are simulated using the finite element method, and the results are validated through experimental testing. The findings confirm that the inclusion of reinforcing patches improves the stress distribution, leading to enhanced load carrying capacity, stiffness, and energy absorption. Compared to the reference tubes, the reinforced tubes exhibit a remarkable increase of 23.25% in the load carrying capacity, 33.46% in the tube’s stiffness, and 23.67% in energy absorption. The analysis of the AE results reveals that both the reference and reinforced tubes experience damage mechanisms such as matrix cracking, fiber-matrix debonding, delamination, and fiber fracture. However, after matrix cracking, delamination becomes dominant in the reinforced tubes, while fiber failure prevails in the reference tubes. Moreover, by combining the AE energy and mechanical energy using the Sentry function, it is observed that the reinforced tubes exhibit a lower rate of damage propagation, indicating superior resistance to damage propagation compared to the reference tubes.