1984
DOI: 10.1002/1097-0142(19840201)53:3<411::aid-cncr2820530308>3.0.co;2-e
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Multivariate analysis of factors associated with invasive fungal disease during remission induction therapy for acute myelogenous leukemia

Abstract: The clinical courses of 54 consecutive adult patients with acute myelogenous leukemia (AML) who underwent 67 courses of intensive remission induction therapy were analyzed to assess factors associated with development of serious fungal and bacterial infections. Fever developed in 65 of 67 remission induction attempts and was due to bacterial, bacterial‐fungal, and fungal etiologies in 49%, 14%, and 9% of cases, respectively. No etiology of fever was found in 28% of cases. Bacteremia occurred in 54% of remissio… Show more

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Cited by 149 publications
(56 citation statements)
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“…Prolonged neutropenia is a major risk factor for invasive fungal infections [3,7,10,18]. Pulmonary defense against Aspergillus appears to depend to a greater degree on early killing of fungal conidia.…”
Section: Discussionmentioning
confidence: 99%
“…Prolonged neutropenia is a major risk factor for invasive fungal infections [3,7,10,18]. Pulmonary defense against Aspergillus appears to depend to a greater degree on early killing of fungal conidia.…”
Section: Discussionmentioning
confidence: 99%
“…Opportunistic pathogens, in particular C. albicans, represent an increasing threat to patients with impaired defense mechanisms (10,12,17,22). We'have 'previously shown that UK-49,858 is more active than ketoconazole and provides significant protection against fulminating C. albicans infections in normal or' cyclophosphamide'treated mice (15).…”
Section: Discussionmentioning
confidence: 99%
“…Fungal bloodstream infections, primarily those caused by Candida species, are now the fourth most common bloodstream infection in the United States (21,29,30,42). Risk factors for the development of Candida bloodstream infection are well recognized and include previous administration of antimicrobial agents (4,33,40), corticosteroids (14,16), or chemotherapeutic agents (14,16,34); hematologic or solid-organ malignancy (16); neutropenia (14,41); extensive intra-abdominal surgery or burns (3,14,16); mechanical ventilation or admission to an intensive care unit (2,4,25,28,33,37); indwelling central venous catheter or parenteral nutrition (2-4, 14, 16, 40); hemodialysis (40); and prior fungal colonization (4,14,28,37,40,41). More recently, there has been an increase in the number of non-Candida albicans Candida species associated with bloodstream infection (1,36).…”
mentioning
confidence: 99%