Multivariate analysis of lifestyle, constitutive and body composition factors influencing bone health in community-dwelling older adults from Madeira, Portugal

Gouveia, Élvio Rúbio; Blimkie, C. J.R.; Maia, José; Lopes, Carla; Gouveia, Bruna R.; Freitas, Duarte L.

doi:10.1016/j.archger.2014.03.001

Cited by 8 publications

(7 citation statements)

References 40 publications

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“…Loss of muscle mass is assessed as part of the screening test for sarcopenia, using the gold standard methods computer tomography (CT) and magnetic resonance imaging (MRI) [47], but also using dual-energy X-ray absorptiometry (DXA) [48–52] or bioimpedance analysis (BIA) [53–58], according to the European Working Group on Sarcopenia [59]. Janssen et al.…”

Section: Resultsmentioning

confidence: 99%

Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

et al. 2016

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BackgroundBecause of the vulnerability and frailty of elderly adults, clinical drug development has traditionally been biased towards young and middle-aged adults. Recent efforts have begun to incorporate data from paediatric investigations. Nevertheless, the elderly often remain underrepresented in clinical trials, even though persons aged 65 years and older receive the majority of drug prescriptions. Consequently, a knowledge gap exists with regard to pharmacokinetic (PK) and pharmacodynamic (PD) responses in elderly subjects, leaving the safety and efficacy of medicines for this population unclear.ObjectivesThe goal of this study was to extend a physiologically based pharmacokinetic (PBPK) model for adults to encompass the full course of healthy aging through to the age of 100 years, to support dose selection and improve pharmacotherapy for the elderly age group.MethodsFor parameterization of the PBPK model for healthy aging individuals, the literature was scanned for anthropometric and physiological data, which were consolidated and incorporated into the PBPK software PK-Sim®. Age-related changes that occur from 65 to 100 years of age were the main focus of this work. For a sound and continuous description of an aging human, data on anatomical and physiological changes ranging from early adulthood to old age were included. The capability of the PBPK approach to predict distribution and elimination of drugs was verified using the test compounds morphine and furosemide, administered intravenously. Both are cleared by a single elimination pathway. PK parameters for the two compounds in younger adults and elderly individuals were obtained from the literature. Matching virtual populations—with regard to age, sex, anthropometric measures and dosage—were generated. Profiles of plasma drug concentrations over time, volume of distribution at steady state (V ss) values and elimination half-life (t ½) values from the literature were compared with those predicted by PBPK simulations for both younger adults and the elderly.ResultsFor most organs, the age-dependent information gathered in the extensive literature analysis was dense. In contrast, with respect to blood flow, the literature study produced only sparse data for several tissues, and in these cases, linear regression was required to capture the entire elderly age range. On the basis of age-informed physiology, the predicted PK profiles described age-associated trends well. The root mean squared prediction error for the prediction of plasma concentrations of furosemide and morphine in the elderly were improved by 32 and 49 %, respectively, by use of age-informed physiology. The majority of the individual V ss and t ½ values for the two model compounds, furosemide and morphine, were well predicted in the elderly population, except for long furosemide half-lifes.ConclusionThe results of this study support the feasibility of using a knowledge-driven PBPK aging model that includes the elderly to predict PK alterations throughout the entire course of aging, and thus to...

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Section: Resultsmentioning

confidence: 99%

Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

et al. 2016

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“…We acknowledge that the cross-sectional design of the present study limits conclusions regarding the direction of the relationships between the identified predictor variables and balance and mobility parameters. Although the Baecke questionnaire used on this study to assess PA has been shown to have acceptable reproducibility (Gouveia et al, 2014), potential difficulties to accurately recall past sport and leisure activities could introduce bias and lead to misclassification. On the other hand, this study is unique in some aspects.…”

Section: Discussionmentioning

confidence: 99%

“…For the current study, the questionnaire also provides a measure of total PA that is the sum of these three specific domains (for validations see e.g. Gouveia et al, 2014).…”

Section: Instrumentsmentioning

confidence: 99%

Balance and mobility relationships in older adults: A representative population-based cross-sectional study in Madeira, Portugal

Gouveia

Ihle

et al. 2019

Archives of Gerontology and Geriatrics

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Background: Balance and mobility impairments are important modifiable risk factors associated with falls in older people.Purpose: To investigate how different functional fitness components relate to balance and mobility, after controlling for age, sex, body mass index (BMI), and different physical activity (PA) domains.Methods: This representative cross-sectional study included 802 individuals, 401 males and 401 females (69.8±5.6 years) from Madeira, Portugal. The Fullerton Advance Balance (FAB) scale was used to assess balance. Mobility in terms of gait velocity, cadence, stride length, and gait stability ratio (GSR) were assessed using the 50-foot Walk test. PA was assessed through a face-to-face interview using the Baecke questionnaire, and functional fitness was assessed with Senior Fitness tests (strength, flexibility, and aerobic endurance).Results: Balance and mobility were negatively associated with age and BMI, and positively related to PA and functional fitness. Moreover, male presented better performance in balance and mobility. Hierarchical multiple regression analyses showed that functional fitness explained the highest amount of variance in balance and all mobility parameters (over and above age, sex, BMI, and PA). Specifically, entering functional fitness components significantly increased explained variance in FAB (+ 19%), gait velocity (+ 25%), cadence (+ 15%), stride length (+ 9%), and GSR (+ 31%).In these models, aerobic endurance consistently had the strongest contribution. Conclusion: Strength, flexibility, and especially aerobic endurance, over and above nonmodifiable variables like age and sex, are related to better performances in balance and mobility and, thereby, possibly prevent falls in older people.

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“…PA was measured using the Baecke Questionnaire [ 58 ]; for validation, see, e.g., Gouveia et al [ 59 ]. The questions investigate PA with a reference period of the last 12 months.…”

Section: Methodsmentioning

confidence: 99%

Muscle Strength and Balance as Mediators in the Association between Physical Activity and Health-Related Quality of Life in Community-Dwelling Older Adults

Nascimento

Gouveia

Campos

et al. 2022

JCM

Self Cite

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Lower extremity muscle strength (LEMS) and body balance (BB) are essential for older adults to maintain an upright posture and autonomously perform their basic activities of daily living. This study aimed to examine whether LEMS and BB mediate the relationship between physical activity (PA) and health-related quality of life (HRQoL) in a large sample of community-dwelling older adults. This is a cross-sectional study carried out with 802 individuals, 401 males and 401 females (69.8 ± 5.6 years), residents of the Autonomous Region of Madeira, Portugal. PA and HRQoL were assessed by the Baecke Questionnaire and e SF-36, respectively. LEMS was assessed by the Senior Fitness Test and BB by the Fullerton Advance Balance (FAB). The serial mediation pathway model pointed out that LEMS and BB partially mediated the association between PA and HRQoL in approximately 39.6% and 47%, respectively. The total variance in HRQoL explained by the entire model was 98%. Our findings may indicate the role that LEMS and BB play in the relationship between PA and HRQoL in the older population.

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Multivariate analysis of lifestyle, constitutive and body composition factors influencing bone health in community-dwelling older adults from Madeira, Portugal

Cited by 8 publications

References 40 publications

Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

Balance and mobility relationships in older adults: A representative population-based cross-sectional study in Madeira, Portugal

Muscle Strength and Balance as Mediators in the Association between Physical Activity and Health-Related Quality of Life in Community-Dwelling Older Adults

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