“…Prior to modelling of the hyperspectral data, preprocessing the images in the image domain, but foremost in the spectral domain, is usually needed (e.g., background removal, scatter correc-tion, de-noising, suppression of sample morphology effects or treatment of dead pixels). 1,8 These big data, structured as hyperspectral image cubes, have relevance in many types of applications, for example agricultural and food sciences, 9,10 for data collection by drones 11 and in the pharmaceutical industry. 12 The applicability of multivariate data analysis for HSI is relevant for process analytical control (PAC) and quality by design (QbD) in a wide range of industrial sectors.…”