Multivariate Longitudinal Modeling of Macular Ganglion Cell Complex

Mohammadzadeh, Vahid; Su, Erica; Shi, Liu; Coleman, Anne L.; Law, Simon K.; Weiss, Robert E.; Nouri‐Mahdavi, Kouros

doi:10.1016/j.xops.2022.100187

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…Our basic bayesian hierarchical model and data analysis without covariates were described previously. 26 We screened data for outliers and removed approximately 0.5% of observations. We inspected profile plots and summary plots 29 and plotted univariate distributions of covariates.…”

Section: Discussionmentioning

confidence: 99%

“…Our basic bayesian hierarchical model and data analysis without covariates were described previously . We screened data for outliers and removed approximately 0.5% of observations.…”

Section: Methodsmentioning

confidence: 99%

“…We recently demonstrated that ganglion cell complex (GCC) thickness had the largest signal among macular structural measures for detection of glaucoma progression in eyes with central or moderate to severe glaucoma damage at baseline . Our recently developed longitudinal bayesian framework enables us to properly estimate global and local structural rates of change in the macular region and provides an opportunity to construct and explore prognostic models based on structural change outcomes …”

Section: Introductionmentioning

confidence: 99%

“…24,25 Our recently developed longitudinal bayesian framework enables us to properly estimate global and local structural rates of change in the macular region and provides an opportunity to construct and explore prognostic models based on structural change outcomes. 26 The purpose of the current study was to investigate the association of baseline BP measures with longitudinal changes of macular GCC within our bayesian hierarchical model. To this aim, we explored the association of BP with macular rates of change after adjusting for relevant demographic and clinical factors, including IOP.…”

mentioning

confidence: 99%

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Association of Blood Pressure With Rates of Macular Ganglion Cell Complex Thinning in Patients With Glaucoma

Mohammadzadeh

Mohammadi

et al. 2023

JAMA Ophthalmol

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ImportanceThere are scarce data on the association of blood pressure measures with subsequent macular structural rates of change in patients with glaucoma.ObjectiveTo investigate the association of baseline blood pressure measures with rates of change of the macular ganglion cell complex in patients with central or moderate to advanced glaucoma damage at baseline.Design, Setting, and ParticipantsThis prospective cohort study, conducted from August 2021 to August 2022, used data from patients in the Advanced Glaucoma Progression Study at the University of California, Los Angeles. Participants were between 39 and 80 years of age and had more than 4 macular imaging tests and 2 or more years of follow-up.ExposuresA diagnosis of glaucoma with either central damage or a visual field mean deviation worse than −6 dB.Main Outcomes and MeasuresThe main outcome was the association of blood pressure measures with ganglion cell complex rates of change. Macular ganglion cell complex thickness rates of change were estimated with a bayesian hierarchical model. This model included relevant demographic and clinical factors. Blood pressure measures, intraocular pressure, and their interactions were added to the model to assess the association of baseline blood pressure measures with global ganglion cell complex rates of change.ResultsThe cohort included 105 eyes from 105 participants. The mean (SD) age, 10-2 visual field mean deviation, and follow-up time were 66.9 (8.5) years, –8.3 (5.3) dB, and 3.6 (0.4) years, respectively, and 67 patients (63.8%) were female. The racial and ethnic makeup of the cohort was 15 African American (14.3%), 23 Asian (21.9%), 12 Hispanic (11.4%), and 55 White (52.4%) individuals based on patient self-report. In multivariable analyses, female sex, history of taking blood pressure medications, higher intraocular pressure, thicker central corneal thickness, shorter axial length, higher contrast sensitivity at 12 cycles per degree, and higher baseline 10-2 visual field mean deviation were associated with faster ganglion cell complex thinning. Lower diastolic blood pressure was associated with faster rates of ganglion cell complex thinning at higher intraocular pressures. For intraocular pressures of 8 and of 16 mm Hg (10% and 90% quantiles, respectively), every 10 mm Hg–lower increment of diastolic blood pressure was associated with 0.011 μm/y slower and –0.130 μm/y faster rates of ganglion cell complex thinning, respectively.Conclusions and RelevanceIn this cohort study, a combination of lower diastolic blood pressure and higher intraocular pressure at baseline was associated with faster rates of ganglion cell complex thinning. These findings support consideration of evaluating and addressing diastolic blood pressure as a therapeutic measure in patients with glaucoma if supported by appropriate clinical trials.

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Section: Discussionmentioning

confidence: 99%

“…Our basic bayesian hierarchical model and data analysis without covariates were described previously . We screened data for outliers and removed approximately 0.5% of observations.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Association of Blood Pressure With Rates of Macular Ganglion Cell Complex Thinning in Patients With Glaucoma

Mohammadzadeh

Mohammadi

et al. 2023

JAMA Ophthalmol

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show abstract

“…However, an analogous analysis of OCT data has not been completed. Although LMMs have been commonly used with OCT data, 9 , 10 , 11 improved performance compared with traditional OLS has not been clearly demonstrated. It is unknown if the LG model would be beneficial when assessing glaucomatous progression with OCT data.…”

mentioning

confidence: 99%