Multivariate Predictors of Occult Neck Metastasis in Early Oral Tongue Cancer

Sparano, Anthony; Weinstein, Gregory S.; Chalian, Ara A.; Yodul, Michael; Weber, Randal S.

doi:10.1016/j.otohns.2004.04.008

Cited by 251 publications

(141 citation statements)

References 17 publications

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“…In our study there was no correlation between lymphovascular and perinueral invasion and neck metastasis but other studies have found them to be independent predictors [16,20].…”

Section: Discussioncontrasting

confidence: 91%

“…Byers et al found that an increasing tumor grade predicted lymph node metastasis (odd ratio2.40) [15]. Sparano et al and Lim et al also showed positive correlation between grade of the tumor and lymph node metastasis [16,17].…”

Section: Discussionmentioning

confidence: 96%

“…Byers et al and Sparano et al in their studies described the correlation between increasing tumor size and lymph node metastasis [15,16].…”

Section: Discussionmentioning

confidence: 97%

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Cervical node metastasis in T1 squamous cell carcinoma of oral tongue- pattern and the predictive factors

Vishak

Rohan

2014

Indian J Surg Oncol

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Background The squamous cell carcinoma (SCC) of the oral tongue is a common cancer in India. Elective lymphadenectomy is generally performed in all patients with T2-T4 tumors. In this study we have tried to analyze the pattern and risk factors associated with lymph node metastasis in T1 tongue cancers. Methods A retrospective review of the records of 57 patients undergoing surgery for treatment of T1 sqamous cell carcinoma of oral tongue was carried out. The clinicopatological features of the tumor, pattern of nodal metastasis and the risk factors associated with lymph node metastasis were studied. Results Totally 57 patients with T1 tumor underwent excision of the primary and modified neck dissection (MND). Lymph node metastasis was found in 36.8 % of the patients. Level I to Level II was the commonest site of metastasis. Skip metastasis at level III and IV was found in 8.5 % of the patients and isolated skip metastasis at level IV in 1.5 % of the patients. The risk factors associated with the lymph node metastasis on univariete analysis were; higher grade, tumor size >1 cm and tumor thickness >3 mm. On multivariate analysis only the tumor thickness was found to be a risk factor for the lymph node metastasis (hazard ratio of 21.59). Conclusions T1 sqamous cell carcinoma of tongue is associated with a high incidence of lymph node metastasis. Elective neck dissection should be considered in all patients with tumors more than 3 mm in thickness

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“…In our study there was no correlation between lymphovascular and perinueral invasion and neck metastasis but other studies have found them to be independent predictors [16,20].…”

Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 96%

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Cervical node metastasis in T1 squamous cell carcinoma of oral tongue- pattern and the predictive factors

Vishak

Rohan

2014

Indian J Surg Oncol

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“…Many histo-pathologic features have been previously investigated as risk factors for occult cervical lymph node metastasis in early OTC but there is no consensus [9,10,18] and there is still controversy regarding the management of clinical N0 neck [19]. The PVI and PLI are identified as the factors of RR but no statistical difference in DFS or OS between elective treatment and observation groups in the present study.…”

Section: Discussionmentioning

confidence: 48%

Impact of Clinical and Histo-Pathological Prognostic Factors on T1-2N0-1 Oral Tongue Carcinoma

Sittitrai

Srivanitchapoom

Mahanupab

et al. 2012

Indian J Otolaryngol Head Neck Surg

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To determine predictive factors which affect local and regional recurrence of T1-2N0-1M0 oral tongue carcinoma (OTC). Records of 42 patients with T1-2N0-1 M0 OTC were reviewed. The clinical characteristics, histopathological data, disease recurrence and survival rate were analyzed. Descriptive statistics and Kaplan-Meier survival analysis were used. The median follow up was 38 months. The 2-year overall survival and disease-free survival rates were 85.7 and 55.6 % respectively. At the 2 year analysis, there were surgical margin\5 mm (p value = 0.01), tumor thickness [7 mm (p value = 0.03), perivascular and perilymphatic invasion (p value = 0.01) affected on local recurrence and perivascular and perilymphatic invasion were also predictors for regional recurrence (p value = 0.04). The surgical margin status, tumor thickness, perivascular and perilymphatic invasion represented significant predictive factors for local recurrent OTC. Postoperative adjuvant therapy should be considered in these groups.

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“…Early tongue and oral floor cancer is known for its propensity for subclinical lymph node metastasis, and the incidence of late neck metastasis has been reported at 20-30% 2,3,4 . It has been reported 5,6 that patients with neck lymph node metastasis tend to develop distant metastasis, even though the regional control is maintained by neck dissection.…”

Section: Introductionmentioning

confidence: 99%

Initial CT findings in early tongue and oral floor cancer as predictors of late neck metastasis

Furusawa¹,

Suzuki²,

Homma³

et al. 2008

Oral Oncology

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Multivariate Predictors of Occult Neck Metastasis in Early Oral Tongue Cancer

Cited by 251 publications

References 17 publications

Cervical node metastasis in T1 squamous cell carcinoma of oral tongue- pattern and the predictive factors

Cervical node metastasis in T1 squamous cell carcinoma of oral tongue- pattern and the predictive factors

Impact of Clinical and Histo-Pathological Prognostic Factors on T1-2N0-1 Oral Tongue Carcinoma

Initial CT findings in early tongue and oral floor cancer as predictors of late neck metastasis

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