2010
DOI: 10.1016/j.ejmech.2010.07.017
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Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98

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Cited by 24 publications
(6 citation statements)
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“…Hatch et al [13] carried out a QSAR study of 39 flavonoids and their inhibitory activity towards mutagenicity of 2-amino-3-methyl-aminoimidazo-[4,5-f]-quinoline (IQ). As was the case in the work of Borges de Melo [5], their dataset was derived from reports of Edenharder [11,17]. It was confirmed that the 4-keto substituent is essential for having antimutagenic activity, as already claimed in Edenharders' publications.…”
Section: Discussionsupporting
confidence: 56%
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“…Hatch et al [13] carried out a QSAR study of 39 flavonoids and their inhibitory activity towards mutagenicity of 2-amino-3-methyl-aminoimidazo-[4,5-f]-quinoline (IQ). As was the case in the work of Borges de Melo [5], their dataset was derived from reports of Edenharder [11,17]. It was confirmed that the 4-keto substituent is essential for having antimutagenic activity, as already claimed in Edenharders' publications.…”
Section: Discussionsupporting
confidence: 56%
“…However, predictions of antigenotoxicity are not included in these programs and reports on the development of QSAR models for the assessment of the antimutagenic activity of flavonoids are scarce. Borges de Melo et al [5] reported the results of a multivariate QSAR study on the antimutagenic activity of flavonoids against 3-nitrofluoranthene on S. typhimurium TA98. Their dataset was derived from the work of Edenharder and Tang [29] and included twenty compounds with antimutagenic activity.…”
Section: Discussionmentioning
confidence: 99%
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“…The QSAR models should be interpretable and it is important to explain the selected descriptors [58]. Definition of each selected descriptor was presented here.…”
Section: Resultsmentioning
confidence: 99%