2021
DOI: 10.5705/ss.202019.0188
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Multivariate Spline Estimation and Inference for Image-on-Scalar Regression

Abstract: Motivated by recent work of analyzing data in the biomedical imaging studies, we consider a class of image-on-scalar regression models for imaging responses and scalar predictors. We propose to use flexible multivariate splines over triangulations to handle the irregular domain of the objects of interest on the images and other characteristics of images. The proposed estimators of the coefficient functions are proved to be root-n consistent and asymptotically normal under some regularity conditions. We also pr… Show more

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Cited by 9 publications
(7 citation statements)
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“…Remark 3. In Theorem 2, the condition n A n|∆| d+2 = o(1) is used for undersmoothing of the slope estimator, which is widely applied in the series approximating estimations (Yu et al, 2020(Yu et al, , 2021. By consistently estimating the asymptotic variance σ β (t, u), the result in Theorem 2 can be used to establish the pointwise confidence interval of the slope function.…”
Section: Theoretical Resultsmentioning
confidence: 99%
“…Remark 3. In Theorem 2, the condition n A n|∆| d+2 = o(1) is used for undersmoothing of the slope estimator, which is widely applied in the series approximating estimations (Yu et al, 2020(Yu et al, , 2021. By consistently estimating the asymptotic variance σ β (t, u), the result in Theorem 2 can be used to establish the pointwise confidence interval of the slope function.…”
Section: Theoretical Resultsmentioning
confidence: 99%
“…, N i , which forms an M -row array with N i points in the i-th row, see Figure 14(a) and Figure 18(a). The similar data setting was also considered in Yu et al (2021).…”
Section: Introductionmentioning
confidence: 99%
“…We then define a direct model for the estimation of a functional discriminant direction in the parametrizing space exploiting a convenient reformulation of the problem into a regularized functional linear regression model, where appropriate differential spatial regularization is introduced to produce interpretable and well-defined estimates. While several regularized regression models for functional data supported on multidimensional domains have been proposed (Goldsmith, Huang, and Crainiceanu 2014;Wang and Zhu 2017;Kang, Reich, and Staicu 2018;Feng et al 2020;Yu et al 2021), these are limited to flat domains as they rely on a global Cartesian coordinate system, which is in general not available on non-linear domains. Moreover, some of these approaches rely on pre-computations of the covariance structure of the functional predictors, which is ultimately not possible in our final application due to the high dimensionality of the data.…”
Section: Introductionmentioning
confidence: 99%