Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study

Zeng, Hongbo; Liu, Ziyi; He, Yunhui; Chen, Huixiang; He, Jun; Liu, Mingke; Wu, Shuiqing; He, Haiqing; Huang, Changkun; Xu, Ran

doi:10.1007/s11255-024-04021-9

Cited by 3 publications

(3 citation statements)

References 50 publications

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“…However, when considering the co-existence of vitamin C with other vitamins, contradictory findings were obtained. The combination of vitamin E and vitamin C was reported to effectively reduce urinary calcium oxalate crystals ( 50 ). Co-exposure to multivitamins containing vitamin C was found to decrease the risk of kidney stones ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

Association between composite dietary antioxidant index and kidney stone prevalence in adults: data from National Health and Nutrition Examination Survey (NHANES, 2007–2018)

Duan,

Huang,

Zhang

et al. 2024

Front. Nutr.

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BackgroundThe high prevalence of kidney stones in adults worldwide has prompted research into potential interventions, one of which involves exploring the consumption of antioxidants that may confer protective effects. However, the relationship between the composite dietary antioxidant index (CDAI), a crucial measure used to assess an individual’s overall antioxidant capacity from daily dietary intake, and kidney stones remains unclear. Therefore, we conducted cross-sectional analysis to examine the association between CDAI and kidney stone prevalence.MethodsThe analysis was conducted utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. Antioxidant intake was derived from two 24-h dietary recalls surveys, while CDAI, a comprehensive measure that includes antioxidants like vitamins A, C, and E, zinc, selenium, and carotenoids, was calculated. Multivariate logistic regression and restricted cubic spline (RCS) regression were utilized to examine the association between CDAI and the prevalence of kidney stones.ResultsThe study included a total of 28,516 participants, with 2,748 individuals having a history of kidney stones. The median of CDAI was −0.01 (−2.02, 2.37). Individuals in the fourth quartile of CDAI exhibited a significantly lower prevalence of kidney stones compared to those in the first quartile (Odds Ratio [OR] = 0.769 [0.633–0.935]), even after adjusting for potential confounding factors (including age, sex, race, education level, poverty income ratio, smoking status, drinking status, body mass index (BMI), energy intake levels, physical activity level, serum calcium concentration, estimated glomerular filtration rate (eGFR), hypertension, diabetes and supplement use). The RCS analysis revealed a non-linear relationship between CDAI and kidney stone prevalence, with inflection points identified at 0.06 (p for non-linearity = 0.039). Subgroup analysis demonstrated consistent CDAI-kidney stone prevalence associations across all subsets. Furthermore, a significant inverse correlation was observed between CDAI and inflammatory markers.ConclusionThis study provides evidence supporting a reciprocal correlation between adult dietary antioxidant intake, as measured by CDAI, and kidney stone prevalence. These findings emphasize the potential benefits of consuming dietary antioxidants in lowering the risk of kidney stone formation.

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Section: Discussionmentioning

confidence: 99%

Association between composite dietary antioxidant index and kidney stone prevalence in adults: data from National Health and Nutrition Examination Survey (NHANES, 2007–2018)

Duan,

Huang,

Zhang

et al. 2024

Front. Nutr.

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“…Their regression analysis revealed that, compared to lower intakes, high intakes of vitamin B6 (OR (95% CI): 0.76 (0.62, 0.93)), vitamin C (OR (95% CI): 0.73 (0.59, 0.90)), and vitamin D (OR (95% CI): 0.77 (0.64, 0.94)) demonstrated protective effects against kidney stones. Additionally, the relationship between vitamin C intake and kidney stone prevalence exhibited a J-shaped curve, initially decreasing before increasing again [ 86 ].…”

Section: Modifiable Lifestyle Factors and Habitsmentioning

confidence: 99%

“…An in vivo study has demonstrated that vitamin C can elevate the excretion of urinary oxalate in hyperoxaluric rats induced with hydroxy-L-proline [ 87 ]. Some researchers speculate that the pro-lithogenic association between vitamin C and kidney stones could be attributed to inadequate preservation techniques or abnormal pH levels during the urine preservation, detection, and analysis processes [ 86 , 88 ]. In contrast, an in vitro study has demonstrated the antioxidative properties of vitamin C, showcasing a protective impact against oxalate-induced oxidative stress and renal damage [ 89 ].…”

Section: Modifiable Lifestyle Factors and Habitsmentioning

confidence: 99%

The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease—A State-of-the-Art Review

Balawender,

Łuszczki,

Mazur

et al. 2024

Nutrients

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Kidney stone disease has a multifactorial etiology, and evolving dietary habits necessitate continuous updates on the impact of dietary components on lithogenesis. The relationship between diseases influenced by lifestyle, such as obesity and diabetes, and kidney stone risk underscores the need for comprehensive lifestyle analysis. Effective management of kidney stones requires a multidisciplinary approach, involving collaboration among nutritionists, urologists, nephrologists, and other healthcare professionals to address the complex interactions between diet, lifestyle, and individual susceptibility. Personalized dietary therapy, based on each patient’s unique biochemical and dietary profile, is essential and necessitates comprehensive nutritional assessments. Accurate dietary intake evaluation is best achieved through seven-day, real-time dietary records. Key factors influencing urinary risk include fluid intake, dietary protein, carbohydrates, oxalate, calcium, and sodium chloride. Personalized interventions, such as customized dietary changes based on gut microbiota, may improve stone prevention and recurrence. Current research suggests individualized guidance on alcohol intake and indicates that tea and coffee consumption might protect against urolithiasis. There is potential evidence linking tobacco use and secondhand smoke to increased kidney stone risk. The effects of vitamins and physical activity on kidney stone risk remain unresolved due to mixed evidence. For diseases influenced by lifestyle, conclusive evidence on targeted interventions for nephrolithiasis prevention is lacking, though preliminary research suggests potential benefits. Management strategies emphasize lifestyle modifications to reduce recurrence risks, support rapid recovery, and identify predisposing conditions, highlighting the importance of these changes despite inconclusive data.

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Association between serum 25-hydroxyvitamin D concentrations and kidney stone: a cohort study in the UK Biobank

Gao,

Huang

2024

Int Urol Nephrol

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Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study

Cited by 3 publications

References 50 publications

Association between composite dietary antioxidant index and kidney stone prevalence in adults: data from National Health and Nutrition Examination Survey (NHANES, 2007–2018)

Association between composite dietary antioxidant index and kidney stone prevalence in adults: data from National Health and Nutrition Examination Survey (NHANES, 2007–2018)

The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease—A State-of-the-Art Review

Association between serum 25-hydroxyvitamin D concentrations and kidney stone: a cohort study in the UK Biobank

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