Multiway Calibration for Creatinine Determination in Human Serum Using the Jaffé Reaction

Abstract

Second-order calibration and multivariate spectroscopic-kinetic measurements in the visible region are proposed to improve the Jaffé method for creatinine assay. Analyses performed on synthetic mixtures containing bilirubin, glucose, and albumin confirm that second-order calibration is useful for creatinine determination in human serum. Quantitative determinations of creatinine with the parallel factor analysis (PARAFAC) and direct trilinear decomposition (TLD) methods were compared. It is shown that both methods can be used for creatinine determination in human serum, with an SEP (standard error of prediction) of 2.22 and coefficient of variability of 6.14% for PARAFAC, and an SEP of 2.38 and coefficient of variability of 6.57% for TLD [corrected].

Multiway Data Analysis: Eigenvector-Based Methods

“…Antunes et al 217 used DTD to successfully resolve kinetic profiles and transport rates of amino acids through liquid membranes using UV-Vis spectroscopy. Guterres et al 218 applied DTD to kineticspectroscopic measurements for determining creatinine in human serum in the presence of unexpected interferents.…”

Analytical applications of second-order calibration methods

“…Other studies in this field have generated second-order data from a diode-array spectrophotometer, taking the measurements of different pH values [58] or measurements of time in a kinetic process [86][87][88]. In this latter study, Amigó et al simultaneously determined three analytes with highly overlapped spectral bands.…”

A Glimpse of Recent Developments in Brazilian Analytical Chemistry

“…Second-order calibration and multivariate spectroscopic-kinetic measurements in the visible region have been proposed to improve the Jaffe method for creatinine assay. Quantitative determinations of creatinine with the PARAFAC and direct Trilinear Decomposition (TLD) methods were used (Guterres et al 2004). A review including contributions from Brazilian and Argentine authors on second-and third-order multivariate calibration has recently appeared in the literature (Escandar et al 2007).…”