Mumps outbreak in a highly vaccinated school population: Assessment of secondary vaccine failure using IgG avidity measurements

Influence of Vaccination Dose and Clinico-Demographical Factors on Antibody Titers against Measles, Rubella, Mumps, and Varicella-Zoster Viruses among University Students in Japan

“…Thus, 2-dose vaccination during early childhood should also be adopted for mumps and varicella, considering the burden of these diseases and the risk of primary or secondary vaccine failures. Several previous studies support our view (19,20). To our knowledge, no previous study has focused on reductions in antibody responses by post-term birth or macrosomia, even though premature infants were reported to have lower antibody titers than term infants for several vaccines (4).…”

Studies on the Association of Meningitis and Mumps Virus Vaccination

“…Therefore a change in immunization policy was recommended to two-dose schedule of measles-mumps-rubella vaccine, which should help reduce the occurrence of mumps outbreaks in highly vaccinated populations (Hersh et al, 1991). The widespread use of a second dose of mumps vaccine among U.S. schoolchildren beginning in 1990 was followed by low reports of mumps cases; which was established at 2010 elimination goal, however, various mumps outbreaks have been reported in several countries at different years (Brockhoff et al, 2010;CDC, 2010b;Cheek et al, 1995;Dayan & Rubin, 2008;Park et al, 2007;Vandermeulen et al, 2009;Vandermeulen et al, 2004). These reports have suggested that secondary vaccine failure played an important role in mumps outbreaks, thus a more effective mumps vaccine or changes in vaccine policies may be considered to prevent future outbreaks.…”

Guidelines for the Prevention and Control of Mumps Outbreaks in Canada

“…There are many studies demonstrating a drop in antibody levels over time (i.e., waning immunity) (16,(38)(39)(40)(42)(43)(44) . The length of antibody persistence is unknown in settings with high vaccine coverage but low or no circulating wild virus, and no data are currently available correlating specific antibody titres with susceptibility to mumps.…”