Mumps outbreak ongoing since October 2007 in the Republic of Moldova

Bernard, Helen; Schwarz, Norbert; Melnic, A.; Bucov, Victoria; Caterinciuc, Natalia; Pebody, Richard; Mulders, Mick N.; Aidyralieva, Chinara; Hahné, Susan

doi:10.2807/ese.13.13.08079-en

Cited by 12 publications

(2 citation statements)

References 8 publications

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“…Cough and dysphagia were seen in 83.3% and 80% of the patients respectively. Our findings were similar to studies done by Arshad et al and Moghe et al 22,23 In a study by Arshad et al, all the patients (100%) were having bilateral parotid enlargement, the hallmark of mumps. 23 Fever was present in 13 (36.1%) boys and 10 (52.6%) girls.…”

Section: Discussionsupporting

confidence: 93%

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Clinical profile of mumps in children in a tertiary care hospital in Kashmir

Bhat

Mir²,

Farooq³

et al. 2023

Int J Contemp Pediatr

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Background Mumps is one of the oldest human illnesses known to humans. Mumps is caused by a paramyxovirus, which is a single-strand RNA virus. Mumps is characterized by painful, unilateral, or bilateral swelling of the salivary glands, in particular, the parotid glands. Methods: This is a hospital-based prospective observational study. All children of age ≤18 years, both males and females with acute onset of unilateral or bilateral tender, self-limited swelling of the parotid or other salivary gland without other apparent cause. Results: Of the 150 clinically diagnosed mumps cases, 87 (58%) were male and 63 (42%) were female (male-to-female ratio of 1.4:1). There was no case below 1 year but there were 40 cases between 1 and 5 years. The 40% belonged to the lower middle class of socioeconomic status as per Kuppuswamy’s scale, followed by the upper-middle and lower-middle class. Only 15 patients (10%) were completely immunized whereas the immunization status of 8% patients was not known, and the rest of the patients were non immunized (82%). Fever was the most common presentation (150 patients;100%), followed by parotid involvement. Parotitis was present in 146 (97.3%) cases at some point during the illness, 36 patients (24%) had unilateral and 110 patients (73.3%) had bilateral involvement. 16% of patients had multiple salivary gland involvement. Mean duration of illness was 9.0±2 days. Conclusions: Mumps is a significant public health problem to warrant investment in prevention through vaccination.

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Section: Discussionsupporting

confidence: 93%

“…Moghe et al reported the median age to be 9.4 years (range: 7 months-38 years) and 97 (60%) were males. 22 In our study, there was no case below 1 year but there were 40 cases between 1 and 5 years, 23 in boys and 17 in girls. The largest number was in the year-group of 6 to 10, with 80 cases, 45 in boys and 35 in girls.…”

Section: Discussionmentioning

confidence: 38%

Clinical profile of mumps in children in a tertiary care hospital in Kashmir

Bhat

Mir²,

Farooq³

et al. 2023

Int J Contemp Pediatr

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Circulation of Two Mumps Virus Genotypes in an Unimmunized Population in India

Vaidya

Chowdhury

Kumbhar

et al. 2013

Journal of Medical Virology

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Two separate outbreaks of fever with parotitis were reported from the Apsinga and Pimpla villages in the Osmanabad district of the Maharashtra State, India during February and March 2012. Meningo-encephalitis was noted in two patients resulting in the death of an 11-year male. Samples of blood and throat swabs were collected from patients with fever and parotitis. Serum samples from suspected (n=62) and convalescent (n=19) patients were tested for mumps virus specific IgM and/or IgG antibodies. Mumps virus specific IgM antibodies were detected in 44 of 62 serum samples (71%). Of the 19 convalescent phase sera 16 had both, anti-mumps virus IgM and IgG antibodies. Twenty-eight throat swabs collected from patients with parotitis were tested by RT-PCR for the SH gene. Twenty-three specimens were found to be positive and nucleotide sequencing of the amplified PCR products revealed circulation of two distinct genotypes that were village specific. Mumps virus genotype C (n=18) was detected in Apsinga village and genotype G (n=5) in Pimpla village. Two mumps virus isolates were also obtained using Vero cells. This is the first report from India confirming simultaneous circulation of mumps virus genotype C in one village and the G genotype in another village only 37 km away.

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Genomic diversity of mumps virus and global distribution of the 12 genotypes

et al. 2014

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The WHO recently proposed an updated nomenclature for mumps virus (MuV). WHO currently recognizes 12 genotypes of MuV, assigned letters from A to N (excluding E and M), which are based on the nucleotide sequences of small hydrophobic (SH) and haemagglutinin-neuraminidase (HN) genes. A total of 66 MuV genomes are available in GenBank, representing eight of the 12 genotypes. To complete this dataset, whole genomes of seven isolates representing six genotypes (D, H, I, J, K and L) and one unclassified strain were sequenced. SH and HN genes of other representative strains were also sequenced. The degree of genetic divergence, predicted amino acid substitutions in the HN and fusion (F) proteins and geographic distributions of MuV strains were analysed based on the updated dataset. Nucleotide heterogeneity between genotypes reached 20% within the SH gene, with a maximum of 9% within the HN gene. The geographic and chronologic distributions of the 12 genotypes were summarised. This review contributes to our understanding of strain diversity for wild type MuV, and the results support the current WHO nomenclature.

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Mumps outbreak ongoing since October 2007 in the Republic of Moldova

Cited by 12 publications

References 8 publications

Clinical profile of mumps in children in a tertiary care hospital in Kashmir

Clinical profile of mumps in children in a tertiary care hospital in Kashmir

Circulation of Two Mumps Virus Genotypes in an Unimmunized Population in India

Genomic diversity of mumps virus and global distribution of the 12 genotypes

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