Mumps virus may damage the vestibular nerve as well as the inner ear

Tsubota, Masahito; Shojaku, Hideo; Ishimaru, Hitomi; Fujisaka, Michiro; Watanabe, Yukio

doi:10.1080/00016480701646305

Cited by 19 publications

(14 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common cause of viral neuritis and cochleitis in childhood is mumps. Hearing loss is seen in approximately 0.005%-0.3% of all post-mumps cases and is generally unilateral and profound [15][16][17] . Mumps vaccination has been made mandatory since 2007 in Turkey; however, it remains a common cause of hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Vestibular System and Etiology in Children with Unilateral Sensorineural Hearing Loss

Birdane¹,

İncesulu²,

Özüdoğru³

et al. 2016

Int Adv Otol

View full text Add to dashboard Cite

OBJECTIVE:The aim of this study was to evaluate the vestibular system of children with unilateral sensorineural hearing loss (USNHL), investigate the etiological factors of USNHL and analyze whether a genetic predisposition exists. MATERIALS and METHODS:Thirty-three children aged less than 18 years with USNHL, who visited the ear, nose, and throat (ENT) department between January 2004 and December 2012, were included in this study. Cases with conductive hearing loss were excluded from the study. The patients were subjected to etiologic, genetic, and ophthalmologic evaluation; radiologic imaging; electronystagmography (ENG); and vestibular evoked myogenic potential (VEMP) tests. The control group, which included 25 healthy children (13 males and 12 females), had undergone audiological assessment and were subjected to ENG and VEMP tests. RESULTS:All of the patients had severe-to-profound hearing loss. Mumps immunoglobulin G was positive in 22 (66.7%) of 33 patients. The 35delG mutation was not found in any of the patients. All of the patients underwent temporal computed tomography (CT) and magnetic resonance imaging (MRI). Inner ear anomaly was present in 51.5% of the patients. Overall, 21 of 31 ENG patients had canal paresis in the affected ear. The VEMP response was absent on the affected side in three patients. The n23 latency average of the patient group was longer than that of the control group. CONCLUSION:Because USNHL causes irreversible problems in children, early diagnosis and auditory rehabilitation are very important. As USNHL is accompanied by inner ear anomaly, children with USNHL should undergo temporal bone CT and MRI. To evaluate the vestibular system, ENG and VEMP are non-invasive and diagnostic tests.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the Vestibular System and Etiology in Children with Unilateral Sensorineural Hearing Loss

Birdane¹,

İncesulu²,

Özüdoğru³

et al. 2016

Int Adv Otol

View full text Add to dashboard Cite

show abstract

“…In order to obtain a greater level of significance, these data require a greater sample. In the study by Tsubota et al, 28 the virus was detected in the endolymph and in the perilymph. The proposed mechanisms of sensorineural HL include atrophy of hair cells in the organ of Corti and stria vascularis, and damage to the myelin sheath around the vestibulocochlear nerve.…”

Section: Discussionmentioning

confidence: 91%

“…Vestibular dysfunction has also been reported in patients with mumps, suggesting that the eighth nerve is involved in the pathology because the utricle, saccule, and semicircular canals are not affected. 13,28 The response to cVEMPs is present in 100% of patients with non-syndromic congenital HL. In these patients, we identified a genetic mutation of the gap junction β 2 (GJB2) gene, accounting for 50% of the cases of non-syndromic autosomal recessive HL.…”

Section: Discussionmentioning

confidence: 99%

Application of Cervical Vestibular-Evoked Myogenic Potentials in Adults with Moderate to Profound Sensorineural Hearing Loss: A Preliminary Study

Ciodaro

Freni

Alberti

et al. 2020

Int Arch Otorhinolaryngol

View full text Add to dashboard Cite

Introduction The cochlea and the vestibular receptors are closely related in terms of anatomy and phylogeny. Patients with moderate to profound sensorineural hearing loss (MPSHL) should have their vestibular organ functions tested. Objective To evaluate the incidence of vestibular abnormalities in patients with MPSHL and to study the correlation between the etiology of hearing loss (HL) and a possible damage to the labyrinth. Methods A case-control retrospective study was performed. In the case group, 20 adults with MPSHL of known etiology were included. The control group was composed of 15 adults with normal hearing. The case group was divided into 4 subgroups based on the etiology (bacterial meningitis, virus, vascular disease, congenital). Cervical vestibular-evoked myogenic potentials (cVEMPs) were used to rate the saccular function and lower vestibular nerve. Results The study was performed in 70 ears, and it highlighted the presence of early biphasic P1-N1 complex in 29 (71.5%) out of 40 ears in the study group, and in all of the 30 ears in the control group (p = 0.001). Regarding the presence or absence of cVEMPs among the four subgroups of patients with MPSHL, the data were statistically significant (p < 0.001). The comparison between the latencies and amplitude of P1-N1 in case and control groups from other studies and in the four subgroups of cases in the present study did not detect statistically significant differences. Conclusion The present study demonstrates that patients with MPSHL have a high incidence of damage to the labyrinthine organs, and it increases the current knowledge about the etiopathogenesis of sensorineural HL, which is often of unknown nature.

show abstract

“…Deafness caused by mumps is usually profound and permanent. Atrophy of hair cells have been observed [22], indicating severe damage to the cochlea as a result of virus infection. The effect of mumps infection on the function of otolith organs in the vestibular system has rarely been studied.…”

Section: Resultsmentioning

confidence: 99%

“…However, it is not clear whether hearing impairment after mumps is a result of the direct effects of viral infection or the indirect effects of local inflammation caused by the viral infection [9]. Potential mechanisms of mumps-associated deafness include atrophy of hair cells and damage of the vestibulocochlear nerve and brain stem regions [22]. …”

Section: Discussionmentioning

confidence: 99%

The potential dysfunction of otolith organs in patients after mumps infection

Zhou

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

ObjectiveTo investigate the relationship between mumps and the extent of hearing impairment and otolith organ damage.MethodsA total of 27 patients with unilateral hearing impairment following mumps were enrolled. The degrees of hearing loss and otolith organ damage were confirmed by audiometric and vestibular evoked myogenic potential [VEMP] tests. All the results were compared and analyzed using Stata 13.0 software for Windows.ResultsThe VEMP thresholds of the affected ears were significantly higher than those of the unaffected ears in both tests (cervical VEMP [cVEMP] test and ocular VEMP [oVEMP] test; p = 0.000 and 0.001, respectively). The mean cVEMP and oVEMP threshold values of the affected ears with hearing impairment for ≤10 years were significantly lower than those of affected ears with hearing impairment for >10 years [p = 0.009 and 0.004, respectively].ConclusionsDeafness resulting from mumps is usually profound and permanent, which indicates severe damage to the cochlea due to the disease. The functions of otolith organs in the vestibular system are also impaired. Over time, the function of the otolith organs or their neural pathway may suffer secondary damage.

show abstract

Mumps virus may damage the vestibular nerve as well as the inner ear

Cited by 19 publications

References 6 publications

Evaluation of the Vestibular System and Etiology in Children with Unilateral Sensorineural Hearing Loss

Evaluation of the Vestibular System and Etiology in Children with Unilateral Sensorineural Hearing Loss

Application of Cervical Vestibular-Evoked Myogenic Potentials in Adults with Moderate to Profound Sensorineural Hearing Loss: A Preliminary Study

The potential dysfunction of otolith organs in patients after mumps infection

Contact Info

Product

Resources

About