Mumpsimpfstoffe: Virologische Grundlagen

Ströhle, Angelika; Germann, D

doi:10.1007/bf01360324

Soz Pr�ventivmed

1995

DOI: 10.1007/bf01360324

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Mumpsimpfstoffe: Virologische Grundlagen

Angelika Ströhle

D Germann

Abstract: The prevention of mumps virus infection relies on the application of live, attenuated mumps virus vaccines. The process of attenuation from a wildtype mumps isolate to a safe vaccine has been empirical. A lower degree of attenuation results in solid immunity but carries an increased risk of post-vaccination meningitis due to the vaccine strain. Currently used vaccine strains are highly attenuated and essentially free of vaccine strain induced disease. However, their immunogenicity may be lower than previously … Show more

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Cited by 2 publications

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Fully vaccinated children are rare: Immunization coverage and seroprevalence in Austrian school children

Ringler¹,

Göbel

Möst³

et al. 2002

Eur J Epidemiol

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Vaccination coverage for vaccine-preventable diseases in Austria as well as in many Central European countries has been reported to be too low to eradicate such diseases and prevent further outbreaks. Austria lacks an adequate surveillance system to monitor prevalence of the diseases, the vaccination coverage and seroconversion. School children aged 10-14 years (n = 1077) were recruited in all four schools in the city of Schwaz, Austria, to present their vaccination documents and to give blood for serological testing (diphtheria, pertussis, measles, mumps, rubella, varicella). All participants received a report with a personal guideline for (re-) vaccination. Overall vaccination coverage was 86.4% for measles, 85.5% for mumps and 35.0% for rubella. Tetanus vaccination coverage was 98.4% for the first, 97.8% for the second and 96.7% for the third dose, while 55.4% of the study subjects received the recommended two booster injections. For diphtheria the corresponding vaccination coverage was found to be almost identical. Pertussis coverage was lower in general (first dose: 90.9%; second dose: 89.0%; third dose: 86.5%). Oral poliomyelitis vaccination showed a coverage of 98.6, 96.5, 95.3%, with 78.7% receiving the fourth dose. Overall 38.7% were classified as fully vaccinated. Seropositivity for measles was found in 90.4%, for mumps in 61.8%, for rubella in 82.3%, for diphtheria in 65.8%, for pertussis in 35.6% and for varicella in 95.0%. In summary, fully vaccinated children are rare and intensive public health efforts will be necessary to reach higher levels of immunity and prevent further outbreaks.

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Fully vaccinated children are rare: Immunization coverage and seroprevalence in Austrian school children

Ringler¹,

Göbel

Möst³

et al. 2002

Eur J Epidemiol

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An Outbreak of Mumps in a Population Partially Vaccinated with the Rubini Strain

Germann

Ströhle

Eggenberger

et al. 1996

Scandinavian Journal of Infectious Diseases

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Since 1991, 6 years after the recommendation of universal childhood triple vaccination against measles, mumps and rubella (M + M + R), Switzerland has been confronted with an increasing number of mumps cases affecting both vaccinated and unvaccinated children. The M + M + R vaccine mainly used in the Swiss population after 1986 contains the highly attenuated Rubini strain of mumps virus. We analysed an outbreak of 102 suspected mumps cases by virus isolation, determination of IgM antibodies to mumps virus in 27 acute phase sera, and verification of vaccination histories. Mumps was confirmed by virus isolation in 88 patients, of whom 72 had previously received the Rubini vaccine strain. IgM antibodies to mumps virus were detected in 24/27 acute phase serum samples. A group of 92 subjects from the same geographic area without signs of mumps virus infection served as controls. IgG antibodies to mumps virus and vaccination status were assessed in these children. The vaccination rate in these controls was 61%, with equal seropositivity for unvaccinated and Rubini-vaccinated subjects. These data support other recent reports which indicate an insufficient protective efficacy of current mumps vaccines.

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Mumpsimpfstoffe: Virologische Grundlagen

Cited by 2 publications

References 47 publications

Fully vaccinated children are rare: Immunization coverage and seroprevalence in Austrian school children

Fully vaccinated children are rare: Immunization coverage and seroprevalence in Austrian school children

An Outbreak of Mumps in a Population Partially Vaccinated with the Rubini Strain

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