Mung bean (Vigna radiata) porous starch for solubility and dissolution enhancement of poorly soluble drug by solid dispersion

Nadaf, Sameer J.; Jadhav, A. J.; Killedar, Suresh G.

doi:10.1016/j.ijbiomac.2020.11.172

Cited by 27 publications

(8 citation statements)

References 61 publications

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“…The increase in water uptake was observed with an increase in temperature. The collapse of starch granules and formation of colloidal solution due to the solubilization of amylopectin and amylose occurs due to an increase in temperature, thus an increase in water absorption with an increase in rehydration might be observed (Nadaf et al, 2021 ). The results are in line with the findings reported by other researchers for rehydration studies of several dried foods.…”

Section: Resultsmentioning

confidence: 99%

Rehydration modeling and characterization of dehydrated sweet corn

Nayi

Kumar

Kachchadiya

et al. 2023

Food Science & Nutrition

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The increasing demand of rehydrated foods is due to its better storage stability at ambient conditions and not requiring refrigeration. Prior to drying at 55, 60, 65, and 70°C in a hot air tray dryer, hot water blanching (HB), steam blanching (SB), and microwave blanching (MB) were employed as pretreatments. Rehydration of dried pretreated sweet corn kernel was performed in boiling water. The pretreatments and drying temperatures were independent factors that affected the dependent factors such as rehydration ratio, total sugar, ascorbic acid, geometric mean diameter, color, sensory evaluation, water absorption, mass, and geometric mean diameter. Peleg, Weibull, and newly proposed models were considered to describe the change in moisture content during rehydration. The proposed model performed better than other models and indicated the rise in equilibrium moisture content of rehydrated sweet corn with an increase in dehydration temperature of sweet corn due to higher R2 (0.994), and lower chi‐square (0.005) and RMSE (0.064). The rehydrated sweet corn obtained from samples processed with microwave blanching and dehydration at 70°C showed higher retention of total sugar, ascorbic acid, geometric mean diameter, and color.

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Section: Resultsmentioning

confidence: 99%

Rehydration modeling and characterization of dehydrated sweet corn

Nayi

Kumar

Kachchadiya

et al. 2023

Food Science & Nutrition

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“…Mung bean starch is produced from legumes of mung bean (Vigna radiate, belonging to the Fabaceae family). It contains a high amount of amylose (40%) and exhibits excellent gelling capacity and cohesiveness [23,24].…”

Section: Introductionmentioning

confidence: 99%

Development of Gastroretentive Carriers for Curcumin-Loaded Solid Dispersion Based on Expandable Starch/Chitosan Films

et al. 2023

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Curcumin, a polyphenolic extract from the rhizomes of turmeric, exhibits antioxidant, anti-inflammatory, and anticancer activities, which are beneficial for the treatment of gastric diseases. However, curcumin’s therapeutic usefulness is restricted by its low aqueous solubility and short gastric residence time. In this study, curcumin-loaded solid dispersion (ratio 1:5) was prepared using Eudragit® EPO (Cur EPO-SD), resulting in an approximately 12,000-fold increase in solubility to 6.38 mg/mL. Expandable films incorporating Cur EPO-SD were subsequently prepared by solvent casting using different types of starch (banana, corn, pregelatinized, and mung bean starch) in combination with chitosan. Films produced from banana, corn, pregelatinized and mung bean starch unfolded and expanded upon exposure to simulated gastric medium, resulting in sustained release of 80% of the curcumin content within 8 h, whereas films based on pregelatinized starch showed immediate release characteristics. Curcumin-loaded expandable films based on different types of starch exhibited similar cytotoxic effects toward AGS cells and more activity than unformulated curcumin. Furthermore, the films resulted in increased anti-inflammatory activity against RAW 264.7 macrophage cells compared with the NSAID, indomethacin. These findings demonstrate the potential of expandable curcumin-loaded films as gastroretentive dosage forms for the treatment of gastric diseases and to improve oral bioavailability.

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“…The thermal behavior of lisinopril and lisinopril ion-pair was investigated using DSC (DSC System; Hitachi High-Tech Science Corp.) equipped with an intracooler and refrigerated cooling system. The samples were analyzed under nitrogen purging (20 mL/min) over the temperature range of 30 to 300 °C at a heating rate of 10 °C/min [24,25].…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

QbD-steered fabrication of lisinopril ion-pair gel for improved skin permeability and bioavailability in rabbits

PAWAR,

MORE,

BHATIA

2023

jrp

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Lisinopril belongs to BCS class III having high solubility and low permeability. Reportedly, the oral bioavailability of lisinopril is 25 to 30% and its effectiveness is limited due to poor permeability. Hence, the current investigation is aimed to formulate transdermal ion-pair gel using a permeation enhancer for enhanced delivery of lisinopril across the stratum corneum and evaluate pharmacokinetics of lisinopril in rabbits. The formation of ion-pair is corroborated using Fourier Transform Infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (XRD), zeta potential, particle size analysis, oil/water partition coefficient study, etc. Optimization of the formulation was done using 3 2 factorial designs. Total nine batches (F1-F9) were prepared and the effect of propylene glycol (mL; X1) and carbopol 934 (%; X2) was investigated on gel viscosity (Y1) and permeability through rabbit's skin at 8h (Y2). Propylene glycol exhibited a non-significant (p>0.05) effect on both gel viscosity and skin permeability whereas carbopol 934 demonstrated significant (p<0.05) positive and negative effects on both, respectively. The viscosity of all the lisinopril ion-pair gel (F1-F9) was ranging between 17.24 ± 2.16 Pa.s (Batch F9) to 7.54 ± 1.34 Pa.s (Batch F4). Ex-vivo permeability of all the prepared batches (F1-F9) across excised rabbit's skin was ranging between 85.93 ± 1.26% (Batch F4) to 62.17 ± 1.57% (Batch F9). Remarkably, optimized formulation (F4) exhibited 1.7 folds improvement in skin permeability and 2.4 folds improvement in bioavailability than plain lisinopril gel. These findings demonstrate that ion pair formation is a promising strategy for significantly improving the skin permeability of lisinopril.

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Mung bean (Vigna radiata) porous starch for solubility and dissolution enhancement of poorly soluble drug by solid dispersion

Cited by 27 publications

References 61 publications

Rehydration modeling and characterization of dehydrated sweet corn

Rehydration modeling and characterization of dehydrated sweet corn

Development of Gastroretentive Carriers for Curcumin-Loaded Solid Dispersion Based on Expandable Starch/Chitosan Films

QbD-steered fabrication of lisinopril ion-pair gel for improved skin permeability and bioavailability in rabbits

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