1991
DOI: 10.1128/mcb.11.5.2778
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Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

Abstract: A family of transcriptional activators has recently been identified in chickens; these transcriptional activators recognize a common consensus motif (WGATAR) through a conserved C4 zinc finger DNA-binding domain. One of the members of this multigene family, cGATA-3, is most abundantly expressed in the T-lymphocyte cell lineage. Analysis of human and murine GATA-3 factors shows a striking degree of amino acid sequence identity and similar patterns of tissue specificity of expression in these three organisms. Th… Show more

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Cited by 276 publications
(204 citation statements)
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“…We were also intrigued by the Gata site, which directly abuts the Ets site within the El footprint. We suspected that Gata-3, a Gata family member that is expressed at high levels in T cells and involved in the regulation of several T-cell-specific genes, would also be a prime candidate for an Ets/Elf-1 binding partner (24,32,35,42,68). However, experiments presented here involving mutation of the Gata site indicate that Gata-3 is probably not involved in the activity of the distal CD4 enhancer.…”
Section: Discussionmentioning
confidence: 39%
See 1 more Smart Citation
“…We were also intrigued by the Gata site, which directly abuts the Ets site within the El footprint. We suspected that Gata-3, a Gata family member that is expressed at high levels in T cells and involved in the regulation of several T-cell-specific genes, would also be a prime candidate for an Ets/Elf-1 binding partner (24,32,35,42,68). However, experiments presented here involving mutation of the Gata site indicate that Gata-3 is probably not involved in the activity of the distal CD4 enhancer.…”
Section: Discussionmentioning
confidence: 39%
“…Footprint El encompasses potential binding sites for Ets and Gata family transcription factors. Several Ets family members (Ets-1, Ets-2, and Elf-1) (1, 58) and a Gata family member (Gata-3) are expressed at high levels in T cells (24,27,32). In Jurkat extracts, the region around these two sequences is well protected and includes the presence of a hypersensitive site.…”
Section: Resultsmentioning
confidence: 99%
“…Library Screening for Mouse GATA Recombinants-A once amplified expression library containing TtT-97 cDNA fragments cloned into the EcoRI site of EX-lox (42) was screened for GATA sequences as described (43) using a conserved DNA-binding domain probe containing the zinc finger domains corresponding to codons 259 -344 of mouse GATA-3 (34). Approximately 750,000 recombinant phage were initially screened with the probe.…”
Section: Methodsmentioning
confidence: 99%
“…Random site selection has suggested that additional nonconsensus sequences can bind GATA proteins with high affinity (32,42). Two of the GATA transcription factors (GATA-1 and GATA-3) are expressed in a tissuerestricted fashion and have been shown previously to regulate lineage-specific gene expression in erythroid cells and T lymphocytes, respectively (24,29,33,72,78). Moreover, homozygous disruption of the GATA-1 gene in mice results in a specific block in erythroid development (56,68).…”
mentioning
confidence: 99%