Murine bladder wall biomechanics following partial bladder obstruction

Chen, Joseph; Drzewiecki, Beth A.; Merryman, W. David; Pope, John C.

doi:10.1016/j.jbiomech.2013.07.022

Cited by 19 publications

(9 citation statements)

References 16 publications

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“…Similar observations have been made in some animal models with similar pathologies . However, decreased compliance is not a ubiquitous phenomenon and several observations in humans and animal pathologies have demonstrated a distended, high compliance bladder . It is not clear whether a low compliance phenotype precedes a more distensible, high compliance bladder, or whether they develop along separate pathways.…”

Section: Extracellular Matrix and Fibrosissupporting

confidence: 52%

See 1 more Smart Citation

Fibrosis and the bladder, implications for function ICI‐RS 2017

Fry

Kitney

Paniker

et al. 2018

Neurourology and Urodynamics

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Section: Extracellular Matrix and Fibrosissupporting

confidence: 52%

“…However, both are associated with an increased deposition of extracellular matrix. It has been noted by some of the above studies that high compliance bladders are associated with poor contractile performance and it is possible that this contributes to the so‐called underactive bladder phenotype.…”

Section: Extracellular Matrix and Fibrosismentioning

confidence: 99%

Fibrosis and the bladder, implications for function ICI‐RS 2017

Fry

Kitney

Paniker

et al. 2018

Neurourology and Urodynamics

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“…These findings overall supported the anisotropy of the bladder tissue, meaning the biomechanical properties depend not only on the sample location but also on the direction in which the force is applied. This property was later confirmed by studies by Chen et al, 2013 [54], Jokandan et al, 2018 [51] and others [44,55]. While Chen et al, 2013 [54] observed a similar trend in the direction of anisotropy, other studies by Parekh et al, 2010 [55] and Zanetti et al, 2012 [44] showed the opposite.…”

Section: Uniaxial Testsmentioning

confidence: 67%

“…This property was later confirmed by studies by Chen et al, 2013 [54], Jokandan et al, 2018 [51] and others [44,55]. While Chen et al, 2013 [54] observed a similar trend in the direction of anisotropy, other studies by Parekh et al, 2010 [55] and Zanetti et al, 2012 [44] showed the opposite. These studies are difficult to compare as they showed different methods of testing (uniaxial, biaxial and others), as well as different sample handling methods and differences in the origin of samples themselves (rats and porcine tissues).…”

Section: Uniaxial Testsmentioning

confidence: 67%

The Significance of Biomechanics and Scaffold Structure for Bladder Tissue Engineering

Hanczar

Moazen

Day

2021

IJMS

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Current approaches for bladder reconstruction surgery are associated with many morbidities. Tissue engineering is considered an ideal approach to create constructs capable of restoring the function of the bladder wall. However, many constructs to date have failed to create a sufficient improvement in bladder capacity due to insufficient neobladder compliance. This review evaluates the biomechanical properties of the bladder wall and how the current reconstructive materials aim to meet this need. To date, limited data from mechanical testing and tissue anisotropy make it challenging to reach a consensus on the native properties of the bladder wall. Many of the materials whose mechanical properties have been quantified do not fall within the range of mechanical properties measured for native bladder wall tissue. Many promising new materials have yet to be mechanically quantified, which makes it difficult to ascertain their likely effectiveness. The impact of scaffold structures and the long-term effect of implanting these materials on their inherent mechanical properties are areas yet to be widely investigated that could provide important insight into the likely longevity of the neobladder construct. In conclusion, there are many opportunities for further investigation into novel materials for bladder reconstruction. Currently, the field would benefit from a consensus on the target values of key mechanical parameters for bladder wall scaffolds.

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“…They postulated these changes prevent normal expansion of the detrusor layer and thereby affect bladder compliance. Non-compliant bladders have also been studied in the context of spinal cord injured and partial bladder obstruction (Chen et al 2013). In these settings, non-compliant bladders were found to have increased density and volume of smooth muscle cells (Hald and Horn 1998), increased quantities of elastin, and decreased collagen fibers in the detrusor layer (Nagatomi et al 2004; Kim et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Layer-dependent role of collagen recruitment during loading of the rat bladder wall

Cheng

Birder

Kullmann

et al. 2017

Biomech Model Mechanobiol

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In this work, we re-evaluated long-standing conjectures as to the source of the exceptionally large compliance of the bladder wall. Whereas these conjectures were based on indirect measures of loading mechanisms, in this work we take advantage of advances in bioimaging to directly assess collagen fibers and wall architecture during biaxial loading. A custom biaxial mechanical testing system compatible with multiphoton microscopy was used to directly measure the layer-dependent collagen fiber recruitment in bladder tissue from 9 male Fischer rats (4 adult and 5 aged). As for other soft tissues, the bladder loading curve was exponential in shape and could be divided into toe, transition and high stress regimes. The relationship between collagen recruitment and loading curves was evaluated in the context of the inner (lamina propria) and outer (detrusor smooth muscle) layers. The large extensibility of the bladder was found to be possible due to folds in the wall (rugae) that provide a mechanism for low resistance flattening without any discernible recruitment of collagen fibers throughout the toe regime. For more extensible bladders, as the loading extended into the transition regime, a gradual coordinated recruitment of collagen fibers between the lamina propria layer and detrusor smooth muscle layer was found. A second important finding was that wall extensibility could be lost by premature recruitment of collagen in the outer wall that cut short the toe region. This change was correlated with age. This work provides, for the first time, a mechanistic understanding of the role of collagen recruitment in determining bladder extensibility and capacitance.

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Murine bladder wall biomechanics following partial bladder obstruction

Cited by 19 publications

References 16 publications

Fibrosis and the bladder, implications for function ICI‐RS 2017

Fibrosis and the bladder, implications for function ICI‐RS 2017

The Significance of Biomechanics and Scaffold Structure for Bladder Tissue Engineering

Layer-dependent role of collagen recruitment during loading of the rat bladder wall

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