Murine candidiasis: Strain dependence of host responses after immunization

Abstract

Summary After recovery from acute infection with live Candida albicans, both CBA/H and BALB/c mice show increased resistance to colonization by the organism. However, the ‘susceptible’ CBA/H mice develop much stronger protective responses than do ‘resistant’ BALB/c mice. This is manifested particularly as a substantial amelioration of the severity of the lesions in the brain, and a very marked reduction in the number of fungal units therein. Analysis of granulocyte function in normal and immune mice of the two strains tended to exclude this as a basis for the different patterns of susceptibility and resistance.

Isolates of Candida albicans that differ in virulence for mice elicit strain-specific antibody-mediated protective responses

“…After immunisation with live C. albicans 3630, both CBA/H and BALB/c mice show increased resistance to infection; however, the tissue-susceptible CBA/H mice develop much stronger protective responses than do tissue-resistant BALB/c mice [40]. This protection was also evident after infection with strains 3683 and SC5314, and correlated with the diverse antibody reactivity generated by this mouse strain.…”

Neutrophil depletion increases susceptibility to systemic and vaginal candidiasis in mice, and reveals differences between brain and kidney in mechanisms of host resistance

“…Recovery from systemic infection with C. albicans in mice induces an antibody response that protects the animals against further challenge (Ashman & Papadimitriou, 1988). Protection is independent of the isolate used for immunization (R. B. Ashman, unpublished data), but the protective effect is more readily detected in mice, such as CBA/CaH, which develop severe lesions .…”

Murine candidiasis: Cell‐mediated immune responses correlate directly with susceptibility and resistance to infection

“…On the other hand, both BALB/c and CBA/H mice show enhanced resistance to rechallenge. Tissue lesions in immune animals are less obvious, and the number of viable organisms recoverable from the brain is significantly less than in infected normal mice (15). Perhaps surprisingly, protection against reinfection is substantially stronger in the susceptible CBA/H strain than in resistant BALB/c mice.…”