Murine Chemokine CXCL2/KC Is a Surrogate Marker for Angiogenic Activity in the Inflammatory Granulation Tissue

Belo, Andrezza V.; Leles, F.; Barcelos, Lucíola da Silva; Ferreira, Mônica Alves Neves Diniz; Bakhle, Y.S.; Teixeira, Mauro M.; Andrade, Sílvia Passos

doi:10.1080/10739680500253535

Cited by 28 publications

(30 citation statements)

References 31 publications

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“…10b). The existence of new vessels, depicted in the histological analysis, corroborated with the previously described result, assessed by hemoglobin content, which provides a wellvalidated index of neovascularization [79]. Additionally, monocytes could also be visualized in the sponge discs of the untreated group (Fig.…”

Section: Inhibition Of Inflammatory Angiogenesissupporting

confidence: 65%

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Pinto

Cunha

Oréfice

et al. 2012

J Mater Sci: Mater Med

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The purpose of this study was to develop triamcinolone acetonide-loaded polyurethane implants (TA PU implants) for the local treatment of different pathologies including arthritis, ocular and neuroinflammatory disorders. The TA PU implants were characterized by FTIR, SAXS and WAXS. The in vitro and in vivo release of TA from the PU implants was evaluated. The efficacy of TA PU implants in suppressing inflammatory-angiogenesis in a murine sponge model was demonstrated. FTIR results revealed no chemical interactions between polymer and drug. SAXS results indicated that the incorporation of the drug did not disturb the polymer morphology. WAXS showed that the crystalline nature of the TA was preserved after incorporation into the PU. The TA released from the PU implants efficiently inhibited the inflammatory-angiogenesis induced by sponge discs in an experimental animal model. Finally, TA PU implants could be used as local drug delivery systems because of their controlled delivery of TA.

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Section: Inhibition Of Inflammatory Angiogenesissupporting

confidence: 65%

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Pinto

Cunha

Oréfice

et al. 2012

J Mater Sci: Mater Med

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“…These factors have been reported to be involved in various types of angiogenesis [10,13,[16][17][18][29][30][31], and may be involved in the skin wound healing in our system.…”

Section: Discussionmentioning

confidence: 99%

“…(CSF3/G-CSF) [11][12][13][14][15], chemokine (C-X-C motif) ligand2 (CXCL2) [16,17], chemokine (C-X-C motif) ligand 12 (CXCL12/SDF1) [18][19][20][21], endothelin 1 (ET1) [22], fibroblast growth factor 1 (FGF 1) [23], hepatocyte growth factor (HGF) [24,25], hypoxia inducible factor 1 alpha (HIF1a) [26], leptin [27], matrix metallopeptidase 9 (MMP9) [18,28,29], serpine/plasminogen activator inhibitor 1 (PAI1) [29][30][31], platelet-derived growth factor-A (PDGF-A) [18,32], transforming growth factor alpha (TGFa) [33,34], transforming growth factor beta 1 (TGFb1) [35,36], tenomodulin (TNMD) [37], and troponin I type 2 (TNNI2) [38,39]. Factors known to be involved in lymphangiogenesis such as fibroblast growth factor 2 (FGF 2) [40,41], c-fos induced growth factor (FIGF/VEGF-D) [42,43], forkhead box C 2 (FOXC2) [44][45][46], and prospero homeobox 1 (PROX1) [46][47][48][49] are also included in the study.…”

Section: Introductionmentioning

confidence: 99%

The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds

Kameyama¹,

Udagawa²,

Hoshi³

et al. 2015

Legal Medicine

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“…. Furthermore, MIP-2 is a marker that shows angiogenic activity along with VEGF and CCL2 47) . Therefore angiogenic activity can be measured from how much MIP-2 is activated.…”

Section: Discussionmentioning

confidence: 99%

Gagamyeonryunggobon-dan(Jiājiǎnyánlínggùběn-dān) induces hair regrowth effect from activating hair follicle

Cho¹,

Hong²,

Yoon³

2016

The Journal of Korean Medicine Ophthalmology and Otolaryngology

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Objective : The purpose of this study is to report the hair regrowth effect of Gagamyeonryunggobon-dan on ICR mice from measuring the change of diverse factors.Methods : Gagamyeonryunggobon-dan was treated by oral administration with 2.5㎎/㎏/day amount for 3 weeks per mouse everyday. Hair regrowth was estimated by change of morphology, angiogenesis, hair follicle activation. The change of morphology was observed with external, internal change and sebaceous gland. Angiogenesis was estimated by image analysis, capillary distribution and angiogenic chemokine(MIP-2). Hair follicle activation was estimated by PCNA, IGF-2 and serotonin.Results : 1. Gagamyeonryunggobon-dan treated group had more and thicker hairs than the group not treated. Especially well developed sebaceous glands were seen in dermis of treated group. 2. Gagamyeonryunggobon-dan treated group had more capillaries near hair follicles of subcutaneous layer and more 2019% MIP-2 positive activity than the group not treated. 3. Gagamyeonryunggobon-dan treated group increased positive activity up to 596% in PCNA, 187% in IGF-2 and 547% in serotonin more than the group not treated.

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Murine Chemokine CXCL2/KC Is a Surrogate Marker for Angiogenic Activity in the Inflammatory Granulation Tissue

Abstract: Anti-angiogenic effect was most clearly and closely correlated with levels of the chemokine KC. Thus, measurement of the chemokine KC might provide an adequate surrogate marker for the functional process of neovascularization in our model.

Cited by 28 publications

References 31 publications

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds

Gagamyeonryunggobon-dan(Jiājiǎnyánlínggùběn-dān) induces hair regrowth effect from activating hair follicle

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