Murine Gut Microbiota and Transcriptome Are Diet Dependent

Carlisle, Erica M.; Poroyko, Valeriy; Caplan, Michael S.; Alverdy, John; Morowitz, Michael J.; Liu, Donald

doi:10.1097/sla.0b013e318262a6a6

Cited by 34 publications

(25 citation statements)

References 41 publications

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“…[32][33][34] The role of immune mechanisms in the regulation of the microbiota has only recently become the subject of investigation. In this study, we identified an IgA-dependent mechanism responsible for the establishment of the "mature" microbiota in adult mice.…”

Section: Discussionmentioning

confidence: 99%

Proteobacteria-specific IgA regulates maturation of the intestinal microbiota

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Proteobacteria-specific IgA regulates maturation of the intestinal microbiota

et al. 2013

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“…In hospitals, Serratia species tend to colonize the respiratory and urinary tracts causing nosocomial infections [62, 63]. In related studies of the GI tract, Serratia increased in formula-fed mice [64] and was positively correlated with infants with colic [65]. …”

Section: Discussionmentioning

confidence: 99%

Systematic Analysis of the Association between Gut Flora and Obesity through High-Throughput Sequencing and Bioinformatics Approaches

Chiu

Huang

Weng

et al. 2014

BioMed Research International

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Eighty-one stool samples from Taiwanese were collected for analysis of the association between the gut flora and obesity. The supervised analysis showed that the most, abundant genera of bacteria in normal samples (from people with a body mass index (BMI) ≤ 24) were Bacteroides (27.7%), Prevotella (19.4%), Escherichia (12%), Phascolarctobacterium (3.9%), and Eubacterium (3.5%). The most abundant genera of bacteria in case samples (with a BMI ≥ 27) were Bacteroides (29%), Prevotella (21%), Escherichia (7.4%), Megamonas (5.1%), and Phascolarctobacterium (3.8%). A principal coordinate analysis (PCoA) demonstrated that normal samples were clustered more compactly than case samples. An unsupervised analysis demonstrated that bacterial communities in the gut were clustered into two main groups: N-like and OB-like groups. Remarkably, most normal samples (78%) were clustered in the N-like group, and most case samples (81%) were clustered in the OB-like group (Fisher's P value = 1.61E − 07). The results showed that bacterial communities in the gut were highly associated with obesity. This is the first study in Taiwan to investigate the association between human gut flora and obesity, and the results provide new insights into the correlation of bacteria with the rising trend in obesity.

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“…We note that diet has been shown to alter microbiota composition and heme oxygenase 1 expression in infants 24 and, more specifically, that oligosaccharides have been found to induce heme oxygenase-1 expression in macrophages and inhibit inflammation in a murine colitis model. 25 We speculate that dietary changes can in fact influence microbiota urobilin production, though further work is needed in this area.…”

Section: Discussionmentioning

confidence: 99%