Murine model for the evaluation of candiduria caused by Candida tropicalis from biofilm

Capote-Bonato, Francieli; Bonato, Denis Vinicius; Ayer, Ilan Munhoz; Magalhães, Larissa Fernandes; Magalhães, Geórgia Modé; Barros, Felipe Farias Pereira da Câmara; Teixeira, Pedro Paulo Maia; Crivellenti, Leandro Zuccolotto; Negri, Melyssa; Svidzinski, Terezinha Inez Estivalet

doi:10.1016/j.micpath.2018.02.036

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…Biofilms in this environment also incorporate numerous host cells and proteins, which contribute to the extracellular matrix (Nett et al, 2015). C. tropicalis similarly forms biofilms on urinary catheter segments in mice (Capote-Bonato et al, 2018). It appears that host response to both C. albicans and C. tropicalis biofilms involves a degree of neutrophilic infiltration (Nett et al, 2015;Capote-Bonato et al, 2018).…”

Section: Insight Into Host Responses To Biofilm Through Animal Modelsmentioning

confidence: 99%

“…C. tropicalis similarly forms biofilms on urinary catheter segments in mice (Capote-Bonato et al, 2018). It appears that host response to both C. albicans and C. tropicalis biofilms involves a degree of neutrophilic infiltration (Nett et al, 2015;Capote-Bonato et al, 2018). However, the biofilms persist despite this response.…”

Section: Insight Into Host Responses To Biofilm Through Animal Modelsmentioning

confidence: 99%

“…Urinary catheter biofilm models have been developed in mice and rats, allowing the study of catheter-associated candiduria ( Wang and Fries, 2011 ; Nett et al, 2014 ; Capote-Bonato et al, 2018 ). As seen with the vascular catheter models, on urinary catheters, C. albicans also forms thick biofilms with dense extracellular matrix ( Wang and Fries, 2011 ; Nett et al, 2015 ).…”

Section: Insight Into Host Responses To Biofilm Through Animal Modelsmentioning

confidence: 99%

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How Biofilm Growth Affects Candida-Host Interactions

Eix

Nett

2020

Front. Microbiol.

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Candida spp. proliferate as surface-associated biofilms in a variety of clinical niches. These biofilms can be extremely difficult to eradicate in healthcare settings. Cells within biofilm communities grow as aggregates and produce a protective extracellular matrix, properties that impact the ability of the host to respond to infection. Cells that disperse from biofilms display a phenotype of enhanced pathogenicity. In this review, we highlight host-biofilm interactions for Candida, focusing on how biofilm formation influences innate immune responses.

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Section: Insight Into Host Responses To Biofilm Through Animal Modelsmentioning

confidence: 99%

Section: Insight Into Host Responses To Biofilm Through Animal Modelsmentioning

confidence: 99%

Section: Insight Into Host Responses To Biofilm Through Animal Modelsmentioning

confidence: 99%

See 1 more Smart Citation

How Biofilm Growth Affects Candida-Host Interactions

Eix

Nett

2020

Front. Microbiol.

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“…Установлено, что грибы Candida являются второй по частоте причиной катетер-ассоциированной ИМП в многопрофильных стационарах [45]. Большинство случаев выявления грибов в моче связано со способностью грибов Candida формировать биопленки на мочевых дренажах в течение 3-7 дней после их установки [7,13,[47][48][49]. Биопленки -это группа микроорганизмов, которые внедряются во внеклеточный матрикс, образуя сложную трехмерную архитектуру на биотических и абиотических поверхностях [2,7].…”

Section: мочевой дренажunclassified

“…Это приводит к значительному снижению эффективности противогрибковых препаратов и при сопутствующей иммуносупрессии возбудители Candida spp. часто вызывают инвазивную форму заболевания [47]. Грибы в составе биопленок значительно более устойчивы и к иммунному ответу [2].…”

Section: мочевой дренажunclassified

Risk factors of the fungal urinary tract infections

2021

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The role of fungi as causative agents of infections is growing. In in-patients, especially at intensive care units, fungal infections might cause serious problems. Studies conducted over recent years shows an increase of fungi detection in urine in in-patients from 5,01 up to 10,63%. Most often, the appearance of fungi in the urine connected with contamination or colonization of the urinary tract. However, in immunocompromised patients, this could be the part of urinary tract infection and even of disseminated fungal process. Candida is the most common cause of fungal urinary tract infections. At the same time, the presence of Candida in urine (candiduria) not always comes with clinical signs of urethritis, cystitis and pyelonephritis. Detection of noCandida albicans agents in urine is increasing, new Candida species revealed are resistant to antifungal drugs so risk of complications is increasing. Recent researches reveal new mechanisms of how Candida interacts with the bacteria that cause urinary infections. The main mechanisms of Candida virulence factors are dimorphism, adhesion proteins — Als1-7,9 and Gls, invasion enzymes — phospholipase, Als3 and Ssa1, as well as enzymes that neutralize reactive oxygen species. The most significant risk factors of fungal urinary tract infection are the presence of a urinary catheter, diabetes mellitus, immunosuppression and previous antibiotic intake. The study of the formation process of the cellular and immune response to Candida makes it possible to identify the main links in the pathogenesis of urinary tract candidiasis, as well as the main role of immunosuppression in the development of the disease.

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