Murine model of tuberculous meningitis: New insight into understanding pathological complications of the disease

Abstract

Background: Dendritic cells (DC) are key regulators of immune response with the ability to affect both the innate and adaptive immune responses and are abundant in the gut mucosa. The severity of shigellosis varies with the serotype involved with S. dysenteriae (SD) producing the severest infections and complications with S. sonnei (SS) being at other end of spectrum usually causing mild self-limiting diarrhea. While shigellae are known to induce the apoptosis of mature DCs, there is no information in cytokine milieu of DCs incubated with different serotypes of Shigellae.