2007
DOI: 10.1161/atvbaha.107.142810
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Murine Models of Vascular Thrombosis

Abstract: Abstract-Thrombotic complications of vascular disease are the leading cause of morbidity and mortality in most industrialized countries. Despite this, safe and effective drugs targeting these complications are limited, especially in the chronic setting. This is because of the complexity of thrombosis in both arteries and veins, which is becoming increasingly evident as numerous factors are now known to affect the fate of a forming thrombus. To fully characterize thrombus formation in these settings, in vivo mo… Show more

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Cited by 169 publications
(174 citation statements)
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References 169 publications
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“…In this model FeCl 3 is applied to the exposed carotid artery to elicit endothelial damage (39,40). Platelets initially adhere to the damaged endothelium and exposed subendothelial matrix, which is rich in collagen, a strong platelet activator (Fig.…”
Section: Enpp2-tg Mice Display a Pronounced Bleeding Defect And Arementioning
confidence: 99%
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“…In this model FeCl 3 is applied to the exposed carotid artery to elicit endothelial damage (39,40). Platelets initially adhere to the damaged endothelium and exposed subendothelial matrix, which is rich in collagen, a strong platelet activator (Fig.…”
Section: Enpp2-tg Mice Display a Pronounced Bleeding Defect And Arementioning
confidence: 99%
“…Platelets accumulate along the damaged vessel wall as platelet ␤3 integrins engage multivalent plasma proteins such as fibrinogen that serve as a bridge to promote platelet-platelet interactions. Platelets farther from the vessel wall release stimulating factors such as ADP that sustain thrombus growth by perpetuating platelet activation and aggregation (39,40). Eventually, the thrombus occludes the vessel wall, and therefore, thrombosis can be monitored by measuring the time required for cessation of blood flow due thrombotic occlusion.…”
Section: Enpp2-tg Mice Display a Pronounced Bleeding Defect And Arementioning
confidence: 99%
“…21 Reactive oxygen species generated in the lumen are thought to be the main contributor of endothelial damage leading to thrombosis. 22 Based on the resemblance of this process to atherosclerotic thrombosis, the method was used in many animal studies to investigate a thrombosis mechanism and to evaluate thrombosis treatment.…”
Section: Discussionmentioning
confidence: 99%
“…19 Among various animal models of endothelial damage, 20,21 rose bengal injection with mild laser illumination can selectively injure ECs and is regarded as the model that best resembles thrombosis in the setting of atherosclerosis. [21][22][23] The resultant denuded segment is restricted to the area of laser illumination. 22,23 Other methods of injuring endothelium include laser injury alone, topical application of chemicals (eg, ferric chloride), and mechanical damage, which may lack specificity in injured cell types, may not result in uniform denudation, or may require direct application of the toxic chemicals onto the brain surface.…”
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confidence: 99%
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