Murine tumor induction by cytomegalovirus

Cunningham, Barry D.; Sims, Ruth; Zimmermann, Eugene R.; Byrd, D.Lamar

doi:10.1016/0030-4220(75)90356-4

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…Oral epithelial tumors that have an association with Epstein–Barr virus include lymphoepithelioma‐like carcinoma, salivary gland lymphoepithelial carcinoma, multiple/bilateral Warthin’s tumor (cystadenolymphoma) of the parotid gland, tonsillar carcinoma, highly undifferentiated carcinomas and oral hairy leukoplakia (Table 3). Epstein–Barr virus thus has been related to tumors of the salivary glands, and cytomegalovirus also has the ability to induce salivary gland neoplasm in immunosuppressed mice (57). However, studies in Finland (13, 115) and the USA (125) failed to identify a relationship between Epstein–Barr virus or human cytomegalovirus and salivary gland tumors.…”

Section: Oral Diseases With a Viral Componentmentioning

confidence: 99%

Oral viral infections of adults

Slots¹

2008

Periodontology 2000

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Section: Oral Diseases With a Viral Componentmentioning

confidence: 99%

Oral viral infections of adults

Slots¹

2008

Periodontology 2000

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“…In the previous viral studies using in humans (3). When malignant salivary gland polyoma virus or cytomegalovirus induetioi-n eoplasms are induced in rats using dieme-of salivary gland tumors no sex difference for thylbenzanthracene the induction of such neo-salivary tumor development was specified (8plasms can be modified by castration and by 10). the administration of sex hormones (4).…”

mentioning

confidence: 99%

Sex hormone involvement in the development of experimental virally induced murine salivary gland tumors

Ferguson

Marshall

1985

J Oral Pathology Medicine

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Mice were given a single inoculation of polyoma virus at birth and then orchideclomised or oopliorectomiscd. Unoperated groups received polyoma virus alone whilst further males received testosterone, and females received oestradiol thrice‐weekly in addition to polyoma virus inoculation. All groups were then observed over the succeeding 370 days for the development of tumors of the submandibular and parotid salivary glands. Polyoma virus inoculation selectively induced salivary gland tumors in 70% of male animals and 30% of female animals given polyoma virus alone. Testosterone therapy increased the salivary tumor frequency from 69–90% whilst orchidectomy reduced the tumor frequency to 50%. Oophorectomy or oestrogen therapy did not significantly alter the salivary gland tumor frequency in females but oestrogen therapy did result in the development of second primary tumors of breast in 60% of female animals bearing salivary gland tumors. The role of androgens in the development of virally induced salivary gland tumors is discussed as are the possible mechanisms responsible for the development of second primary tumor of breast.

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“…Other experiments in tumoral induction in salivary glands were done with the SE polyoma virus (9-10). Law and Dawe (11) did this on animals previously irradiated by X rays to provoke inmunodepression, while Cunningham et al (12) produced experimental tumors with cytomegalovirus. Others have analyzed the serial transplantations of tumors induced by different chemical carcinogens such as DMBA (13)(14)(15).…”

mentioning

confidence: 99%