Murine Typhus: An Unrecognized Suburban Vectorborne Disease

Civen, Rachel; Ngo, Van

doi:10.1086/527443

Cited by 261 publications

(272 citation statements)

References 40 publications

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“…For R. typhi, fatality is generally less than 1-2%, with a global distribution with its main vector, the flea Xenopsylla cheopis. R. felis, also globally distributed, is primarily associated with Ctenocephalides fleas (Civen and Ngo 2008, Reif and Macaluso 2009, Eisen and Gage 2012.…”

Section: R Ickettsioses Are Vector-borne Zoonotic Infectionsmentioning

confidence: 99%

“…Murine typhus presents after an incubation period of approximately 7-14 days with acute fever, severe headache, myalgia, arthralgia, and macular or maculopapular rash that affects the trunk and distributes in a centrifugal fashion (present in approximately 50% of cases) (Civen and Ngo 2008).…”

Section: Vector-borne and Zoonotic Diseasesmentioning

confidence: 99%

“…The potential association with place of residence merits further investigation because it could be explained by the role of other host animals such as opossums, cats, and dogs (Hii et al 2011) or the activity of other flea species different from X. cheopis (Eisen and Gage 2012). Such extension of the range of possible infection sources could explain the changing behavior of flea-borne rickettsioses from urban disease to a suburban or even rural infection (Civen and Ngo 2008).…”

mentioning

confidence: 99%

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Flea-Borne Rickettsioses in the North of Caldas Province, Colombia

Hidalgo

Montoya

Martínez

et al. 2013

Vector-Borne and Zoonotic Diseases

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Rickettsia typhi and R. felis are the etiological agents of murine typhus and flea-borne spotted fever, respectively. Both are emerging acute febrile zoonotic diseases for which fleas are vectors; they also have similar clinical characteristics and global distribution. In 2005, we identified the circulation of murine typhus in 6 towns within the mountainous coffee-growing area north of Caldas, Colombia. We now report the specific seroprevalence against R. typhi and R. felis, and associated risk factors in 7 towns of this province. The combined seroprevalence against the 2 flea-borne rickettsioses is the highest yet reported in the literature: 71.7% (17.8% for R. felis, 25.2% for R. typhi, and 28.7% for both). We also report a prospective analysis of 26 patients with a febrile illness compatible with rickettsioses, including murine typhus; 9 of these patients had a rickettsiosis. This supports our sero-epidemiological results and highlights the diagnostic complexity of febrile syndromes in this region.

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Section: R Ickettsioses Are Vector-borne Zoonotic Infectionsmentioning

confidence: 99%

Section: Vector-borne and Zoonotic Diseasesmentioning

confidence: 99%

mentioning

confidence: 99%

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Flea-Borne Rickettsioses in the North of Caldas Province, Colombia

Hidalgo

Montoya

Martínez

et al. 2013

Vector-Borne and Zoonotic Diseases

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“…Riketsje to bakterie, które żyjąc wewnątrzkomór-kowo, atakują białe krwinki układu odpornościowego (23). Drobnoustroje te powszechnie występują w populacji szczurów na całym świecie (23).…”

Section: Artykuł Przeglądowy Reviewunclassified

Free-living animals as a source of zoonotic microorganisms

Żmudzki¹

2017

Medycyna Weterynaryjna

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SummaryFree-living animals mainly representing Chioptera (particularly bats), Rodentia, Aves and Carnivora are a source of a number of zoonotic pathogens responsible for significant worldwide human morbidity and mortality. The role of bats and rodents as the primary hosts of zoonotic microorganisms has been extensively characterized. The next important group represented by Paramyxoviridae, followed by Filoviridae (Marburg and Ebola viruses), as well as SARS coronavirus have been also reviewed. Avian influenza viruses are precursors of human influenza A viruses. They might be transmitted directly from free-ranging birds and poultry to humans. The importance of vectors in pathogen transmission from free-living animals to humans has been presented.

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“…R. typhi is maintained transovarially in fleas where it multiplies in the epithelium of the flea midgut. Fleas are capable of multiple feeding, and thus potentially transmitting the Rickettsia to several hosts (Civen and Ngo, 2008;Mouffok et al, 2011;Traub and Wisseman, 1978).…”

Section: Fleamentioning

confidence: 99%

Update on Rickettsioses in Slovakia

Sekeyová¹,

Socolovschi²,

Špitalská³

et al. 2013

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Summary. -The reported incidence of vector-borne diseases including various cases of Rickettsioses in humans is increasing due to a combination of climatic and social factors, escalating the opportunities for contact between people and ticks, fleas or lice. Many of the emerging infectious diseases currently challenging human health in Europe are transmitted by ticks which normally feed on domestic or wild animals. Each Rickettsia spp. has one or several tick vectors, and their geographical distribution varies according to geographical conditions; e.g.; altitude or temperature, which is gradually changing due to a global warming. Evidence of Rickettsia spp. particularly of a newly discovered species is a strong indication that a great number of diseases may be caused by so far undetected or unrecognized organisms. Their diagnosis relies mostly on rare "spot like" cooperation of clinicians with scientists, the members of the working groups that are devoted to the scientific studies of the corresponding research areas. The clinical picture of the disease caused by rickettsiae varies significantly from flu like symptoms to severe fatal outcomes, reflecting the various factors, e.g. a variability of virulence of rickettsial species due to cell invasion, dissemination of rickettsiae, genomics, immune response of an infected organism, or a tricky impact of a treatment. Several major reviews on rickettsioses have been previously published, e.g. in 1997(Parola et al., 2005, and in 2011 (Botelho-Nevers and Raoult, 2011). In this work we intend to present a short historical overview and to describe new trends in research studies of rickettsiology. The main focus will be on rickettsioses affecting Europe΄s population.

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Murine Typhus: An Unrecognized Suburban Vectorborne Disease

Cited by 261 publications

References 40 publications

Flea-Borne Rickettsioses in the North of Caldas Province, Colombia

Flea-Borne Rickettsioses in the North of Caldas Province, Colombia

Free-living animals as a source of zoonotic microorganisms

Update on Rickettsioses in Slovakia

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