“…The presence of papilledema and/or sixth nerve palsy in these cases cannot be explained by raised intracranial pressure and brain imaging, suggesting that the cranial nerves may be directly involved by a separate process, which could be vasculitic in nature. 16,[29][30][31] Signal alteration in the splenium of corpus callosum on brain MR imaging has been reported in a variety of conditions including infections, demyelination, ischemia, and metabolic abnormalities. 32 Infectious etiology associated with splenium injury include viruses (e.g., HIV, HHV6, rotavirus, measles), bacterial (e.g., Salmonella, Escherichia coli O157:H7, tuberculosis, Lyme disease) and parasites (e.g., malaria, toxoplasmosis, cysticercosis).…”