Musa acuminata and its bioactive metabolite 5-Hydroxymethylfurfural mitigates quorum sensing (las and rhl) mediated biofilm and virulence production of nosocomial pathogen Pseudomonas aeruginosa in vitro

Vijayakumar, K. R.; Thirunanasambandham, Ramanathan

doi:10.1016/j.jep.2019.112242

Cited by 38 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5-hydroxymethylfurfural, known as HMF-5, is a furfural derivative and has great added value for the pharmaceutical industries. This aldehyde is applied in chemical syntheses with high ethnopharmacological power in the fight against infections. − …”

Section: Resultsmentioning

confidence: 99%

Characterization by Fast-GC × GC/TOFMS of the Acidic/Basic/Neutral Fractions of Bio-Oils from Fast Pyrolysis of Green Coconut Fibers

Farrapeira

Andrade

Schena

et al. 2022

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Green coconut (Cocos nucifera L. var. dwarf) is one of the most cultivated commodities on the Brazilian coast. Most green coconut waste is burned or disposed of as garbage on coconut-producing properties, on the streets of large cities, and in landfills. Incorrect disposal of coconut waste causes several problems as proliferation of disease vectors, occupation of large areas in landfills, production of gases, and contamination of soil and groundwater. The conversion of this biomass can be carried out through pyrolysis. The bio-oil from the pyrolytic process has a complex chromatographic profile requiring a fractionation step to improve its separation and characterization. In this work, the bio-oil was fractionated according to its acidity (strongly acidic, slightly acidic, basic, and neutral), and both the bio-oil and the fractions were analyzed by fast-GC × GC/TOFMS. The fractionation process used was able to reduce the complexity of the generated crude bio-oil. Three hundred and five different compounds were identified between the fractions analyzed and the crude bio-oil. The time for each analysis was 19 min, demonstrating the gain of the separation/detection technique without losing quality in the identification. The majority of the compounds in the fractions were phenol, catechols, eugenols, and furfural, reinforcing the idea of using this bio-oil as a precursor in the chemical industry.

show abstract

Section: Resultsmentioning

confidence: 99%

Characterization by Fast-GC × GC/TOFMS of the Acidic/Basic/Neutral Fractions of Bio-Oils from Fast Pyrolysis of Green Coconut Fibers

Farrapeira

Andrade

Schena

et al. 2022

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

show abstract

“…MAM significantly inhibits the biofilms of Pseudomonas aeruginosa and inhibits QS-mediated virulence. The anti-QS activity of MAM is mediated by 5-hydroxymethylfurfural [85]. Water extracts of Nymphaea tetragona significantly lower the levels of violacein of Chromobacterium violaceum.…”

Section: Regulation Of Natural Products On Bacterial Virulencementioning

confidence: 98%

Effects of Natural Products on Bacterial Communication and Network-Quorum Sensing

Yang

Meng

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Quorum sensing (QS) has emerged as a research hotspot in microbiology and medicine. QS is a regulatory cell communication system used by bacterial flora to signal to the external environment. QS influences bacterial growth, proliferation, biofilm formation, virulence factor production, antibiotic synthesis, and environmental adaptation. Through the QS system, natural products can regulate the growth of harmful bacteria and enhance the growth of beneficial bacteria, thereby improving human health. Herein, we review advances in the discovery of natural products that regulate bacterial QS systems.

show abstract

“…The interference with the QS communication systems may be the key to the treatment of biofilm-related infections. 7,255–258 QS inhibitors (QSI) can act to inactivate AI synthases or receptors through competitive binding or structural modification. Furthermore, QSI can switch off signal transmission through degradation.…”

Section: Phytochemicals As Antibiofilm Agents: Biological and Biochem...mentioning

confidence: 99%

The action of phytochemicals in biofilm control

et al. 2023

View full text Add to dashboard Cite

show abstract

Musa acuminata and its bioactive metabolite 5-Hydroxymethylfurfural mitigates quorum sensing (las and rhl) mediated biofilm and virulence production of nosocomial pathogen Pseudomonas aeruginosa in vitro

Cited by 38 publications

References 37 publications

Characterization by Fast-GC × GC/TOFMS of the Acidic/Basic/Neutral Fractions of Bio-Oils from Fast Pyrolysis of Green Coconut Fibers

Characterization by Fast-GC × GC/TOFMS of the Acidic/Basic/Neutral Fractions of Bio-Oils from Fast Pyrolysis of Green Coconut Fibers

Effects of Natural Products on Bacterial Communication and Network-Quorum Sensing

The action of phytochemicals in biofilm control

Contact Info

Product

Resources

About