Musa paradisiaca Linn Mucilage as a Disintegrant in Design of Fast Dissolving Tablets

Shirsand, S B; Ashwini, .; Shailashri,; Keshavshetti, Ganesh Gundu; Shivanand,

doi:10.5530/rjps.2015.2.3

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…The dried mass was grinded in mixture to get fine powder and passed to mesh #60. The pulp powder was dried in oven at 50 o C, powdered, passed through #60 mesh, weighed and stored in air tight well closed container 4 .…”

Section: Extraction Of Annona Reticulata (Pulp Powder)mentioning

confidence: 99%

“…Custard apple is rich of flavonoids, alkaloids, and acetogenins. It is easily available, low cost and non-toxic as compared to synthetic disintegrants 4 . In the present study, the fast dissolving tablets of Ritonavir and Lopinavir in fixed dose were prepared by direct compression method using natural and synthetic disintegrants to compare the efficiency of different natural and synthetic disintegrants.…”

Section: Introductionmentioning

confidence: 99%

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Formulation, Evaluation of Fast Dissolving Tablet of Anti-Hiv Drugs as Fixed Dose Combination: Use of Freeze-Dried Powder of Annona Reticulata and Comparison With Synthetic Superdisintegrants

Pingale

2019

J. Pharm. Sci. Innov.

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The aim of the present research work was to prepare and evaluate fast dissolving tablets (FDTs) of fixed dose combination (FDC) of anti-HIV drugs Ritonavir and Lopinavir with a view to enhance patient compliance and minimizes the side effects. In the cited study, fast dissolving tablets of Ritonavir and Lopinavir were formulated by direct compression method using freeze dried powder of Annona reticulata (Custard apple) pulp as a natural disintegrants and synthetic superdisintegrants like Crospovidone, Sodium Starch Glycolate (SSG) and Croscarmellose Sodium (Ac-di-sol) in different ratios with directly compressible mannitol as a diluent to improve the mouth feel. The prepared formulations were evaluated for various parameters including hardness, friability, drug content, in vitro dispersion time, wetting time, water absorption ratio, in vitro drug release studies, stability studies and excipients interaction studies. Among all the formulations, the formulation (FCA4) containing 5% w/w pulp of Annona reticulata was the overall best formulation based on in vitro drug release studies. Stability studies on selected formulations indicated that there were no significant changes in drug content and in vitro dispersion time. The final FDT was robust and disintegrated in 1 mL of fluid in 10 s with up to 4 tablets dissolving in 4 mL to achieve varying doses accommodated in a common teaspoon. From the above studies, it can be concluded that fast dissolving tablets of Ritonavir + Lopinavir can be prepared using different natural superdisintegrants for faster dispersion and disintegration in the mouth.

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Section: Extraction Of Annona Reticulata (Pulp Powder)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation, Evaluation of Fast Dissolving Tablet of Anti-Hiv Drugs as Fixed Dose Combination: Use of Freeze-Dried Powder of Annona Reticulata and Comparison With Synthetic Superdisintegrants

Pingale

2019

J. Pharm. Sci. Innov.

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“…It is also reported by S. B. Shirsand et al, 2016 that Aegle marmelos gum can be used as disintegrant in design of fast dissolving tablets [10]. Yogesh Joshi et al, has also reported that Aegle marmelos gum can be used for sustained release matrix tablets [11].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Bioavailability of Glipizide Using Solid Dispersions With Gum Aegle Marmelos

MALLICK¹,

Mahapatra²,

Murthy³

et al. 2022

Int J App Pharm

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Objective: The aim of the proposed study was formulation and in vitro/ vivo evolution of solid dispersions of glipizide with gum Aegle marmelos. Methods: The phase solubility of glipizide in 0.1N HCl was investigated in the presence of different concentrations of gum Aegle marmelos. The solid dispersions (SDs) of glipizide with gum Aegle marmelos were formulated using solvent evaporation method at ratios of 1:1, 1:2, and 1:5 (glipizide: gum Aegle marmelos). Dissolution studies were conducted. The physicochemical characterization of the formulations was performed by using Fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Subsequently, bioavailability of pure glipizide, solid dispersion and marketed product was performed in rat. Results: Glipizide solubility increased as the concentration of gum Aegle marmelos in 0.1N HCl was raised. The solubility study indicates spontaneous drug solubilization, which is supported by negative values of Gibb's free energy (ΔGotr). Glipizide rate of dissolution was increased in SDs containing gum, and the rate increased as the concentration of gum in the SDs increases. After preparing SDs and physical mixtures with gum, the mean dissolution time (MDT) of glipizide decreases considerably. FTIR spectroscopy study revealed that stability and the absence of a well-defined glipizide-gum interaction. The amorphous condition of glipizide in SDs of glipizide with gum was revealed by DSC and XRD studies. Conclusion: The DSC and XRD studies indicate conversion of drug from crystalline to microcrystalline or amorphous form after formulation of solid dispersion with Aegle gum. The solid dispersion of glipizide with Aegle gum (893.04±25.5) showed better therapeutic activity compared to pure glipizide (535.65±11.5) and marketed formulation (767.5±13.6).

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Plant‐Based Biopolymers in Food Industry: Sources, Extraction Methods, and Applications

Kamble,

Singh,

Singh

et al. 2024

Biopolymers in Pharmaceutical and Food Applications

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Musa paradisiaca Linn Mucilage as a Disintegrant in Design of Fast Dissolving Tablets

Cited by 3 publications

References 4 publications

Formulation, Evaluation of Fast Dissolving Tablet of Anti-Hiv Drugs as Fixed Dose Combination: Use of Freeze-Dried Powder of Annona Reticulata and Comparison With Synthetic Superdisintegrants

Formulation, Evaluation of Fast Dissolving Tablet of Anti-Hiv Drugs as Fixed Dose Combination: Use of Freeze-Dried Powder of Annona Reticulata and Comparison With Synthetic Superdisintegrants

Enhancement of Bioavailability of Glipizide Using Solid Dispersions With Gum Aegle Marmelos

Plant‐Based Biopolymers in Food Industry: Sources, Extraction Methods, and Applications

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