Muscarine, imidazole, oxazole and thiazole alkaloids

Jin, Zhong

doi:10.1039/c6np00067c

Cited by 156 publications

(53 citation statements)

References 341 publications

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“…A number of reviews on marine peptides have appeared in recent years, focusing mainly on their biological activities, applications and biosynthesis as well as isolation procedures [ 16 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. In this review, several works related to the methods used for determination of the absolute configuration of marine peptides by chromatographic methods are presented in different sections according to the source of the marine peptides.…”

Section: Introductionmentioning

confidence: 99%

Marine Natural Peptides: Determination of Absolute Configuration Using Liquid Chromatography Methods and Evaluation of Bioactivities

et al. 2018

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Over the last decades, many naturally occurring peptides have attracted the attention of medicinal chemists due to their promising applicability as pharmaceuticals or as models for drugs used in therapeutics. Marine peptides are chiral molecules comprising different amino acid residues. Therefore, it is essential to establish the configuration of the stereogenic carbon of their amino acid constituents for a total characterization and further synthesis to obtain higher amount of the bioactive marine peptides or as a basis for structural modifications for more potent derivatives. Moreover, it is also a crucial issue taking into account the mechanisms of molecular recognition and the influence of molecular three-dimensionality in this process. In this review, a literature survey covering the report on the determination of absolute configuration of the amino acid residues of diverse marine peptides by chromatographic methodologies is presented. A brief summary of their biological activities was also included emphasizing to the most promising marine peptides. A case study describing an experience of our group was also included.

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Section: Introductionmentioning

confidence: 99%

Marine Natural Peptides: Determination of Absolute Configuration Using Liquid Chromatography Methods and Evaluation of Bioactivities

et al. 2018

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“…This compound class is also a crucial part of many natural products such as vitamin B1 (thiamine), epothilone, dolastatin, and many more (Fig. 2) [15–24]. Moreover, thiazoles are widely applied as pesticides and dyes [25].…”

Section: Introductionmentioning

confidence: 99%

N-Propargylamines: versatile building blocks in the construction of thiazole cores

Arshadi

Vessally

Edjlali

et al. 2017

Beilstein J. Org. Chem.

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Thiazoles and their hydrogenated analogues are not only key structural units in a wide variety of natural products but they also constitute important building blocks in medicinal chemistry. Therefore, the synthesis of these compounds using new protocols is always interesting. It is well known that N-propargylamines can undergo a number of cyclization reactions to produce various nitrogen-containing heterocycles. In this review, we highlight the most important developments on the synthesis of thiazole and its derivatives starting from N-propargylamines. This review will be helpful in the development of improved methods for the synthesis of natural and biologically important compounds.

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“…The oxazole motif is found in many compounds with useful applications and their synthesis is an active task in different areas of research [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. In 2013, Strand and co-workers pioneered the first efficient gold-catalyzed three-component domino reaction to generate trisubstituted oxazoles directly from imines, alkynes, and acid chlorides ( Scheme 6 , Scheme 7 and Scheme 8 ) [ 61 ].…”

Section: Gold-catalyzed Multicomponent Reactionsmentioning

confidence: 99%

Gold Catalyzed Multicomponent Reactions beyond A3 Coupling

et al. 2018

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The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity. This review intends to illustrate important gold-catalyzed examples for the past ten years leading to interesting skeletons involved in biologically active compounds.

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Muscarine, imidazole, oxazole and thiazole alkaloids

Cited by 156 publications

References 341 publications

Marine Natural Peptides: Determination of Absolute Configuration Using Liquid Chromatography Methods and Evaluation of Bioactivities

Marine Natural Peptides: Determination of Absolute Configuration Using Liquid Chromatography Methods and Evaluation of Bioactivities

N-Propargylamines: versatile building blocks in the construction of thiazole cores

Gold Catalyzed Multicomponent Reactions beyond A3 Coupling

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