Muscarinic and nicotinic influences on masculine sexual behavior in rats: Effects of oxotremorine, scopolamine, and nicotine

Retana‐Márquez, Socorro; Salazar, Emilio Dominguez; Velázquez‐Moctezuma, Javier

doi:10.1016/0091-3057(93)90024-n

Cited by 22 publications

(5 citation statements)

References 16 publications

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“…However, the coadministration of testosterone and oxotremorine fully restored sexual behavior. This effect was greater than that of T alone and suggests that the facilitative effect o f cholinergic stimulation on sexual behavior requires the presence o f androgens (Retana-Marquez & Velazquez-Moctezuma, 1993).…”

Section: Androgens and Brain Structurementioning

confidence: 78%

“…Additional research has examined actions o f androgens on specific cholinergic receptors. For example, in rats, stimulation of the muscarinic receptors in the medial preoptic area is involved in facilitating sexual behavior (Hull, et al, 1988), and administration of the muscarinic receptor antagonist scopolamine leads to suppression of sexual behavior (Retana-Marquez, Dominguez, & Velazquez-Moctezuma, 1993).…”

Section: Androgens and Brain Structurementioning

confidence: 99%

“…Continuing evidence points to the involvement o f androgens in multiple aspects of CNS regulation and development. Production of androgens is widespread in the brain of adult animals and androgens have been shown to influence several o f the major neurotransmitter systems, including the cholinergic system (Nakamura, Fujita, & Kawata, 2002;Retana-Marquez, Dominguez, & Velazquez-Moctezuma, 1993;Ishunina, Fisser, & Swaab, 2002). Furthermore, androgens have been tied to changes in the structure of multiple brain regions associated with learning and memory and have been observed to enhance cognitive functioning, especially in tasks related to mnemonic functioning.…”

Section: Androgens and Attention 18mentioning

confidence: 99%

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Effects of gonadectomy and androgen supplementation on attention in male rats

Johnson

Burk

2006

Neurobiology of Learning and Memory

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Androgens are hypothesized to enhance aspects of mnemonic processing. However, it is unclear whether the memory improvement is associated with changes in earlier aspects of information processing, such as attention. The present experiments examined the effects of gonadectomy or supplementation with testosterone or dihydrotestosterone on performance of male rats in a two-lever attention task that required discrimination of visual signals and non-signals. In Experiment 1, Long-Evans rats were trained in the attention task and then underwent gonadectomy or sham-surgery. Postsurgically, animals were tested for 20 sessions in the attention task and then received manipulations designed to increase attentional demands. Gonadectomized and sham-treated animals performed similarly during immediate postsurgical testing and across all manipulations. Finally, the effects of administering the muscarinic receptor antagonist scopolamine (0, 0.1, and 0.2 mg/kg) on attentional performance were assessed for all animals. Scopolamine decreased accuracy of signal detection but did not differentially affect gonadectomized and sham-treated animals. In Experiment 2, a new group of rats (not gonadectomized) was trained to perform the attention task and subsequently administered testosterone (0, 0.1, and 0.5 mg/kg) or dihydrotestosterone (0, 0.1, and 0.5mg/kg) prior to performing the standard version of the attention task and in the presence of a visual distractor. Testosterone (0.5 mg/kg) decreased accuracy on non-signal trials and, at 0.1 mg/kg, decreased latencies to retrieve a reward. Dihydrotestosterone (0.5 mg/kg) decreased accuracy on non-signal trials during visual distractor sessions. The present data do not support the hypothesis that alterations in attention critically mediate androgen-induced changes in mnemonic processing. Supra-physiological androgen levels appear to be capable of impairing attentional processing.

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Section: Androgens and Brain Structurementioning

confidence: 78%

Section: Androgens and Brain Structurementioning

confidence: 99%

Section: Androgens and Attention 18mentioning

confidence: 99%

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Effects of gonadectomy and androgen supplementation on attention in male rats

Johnson

Burk

2006

Neurobiology of Learning and Memory

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“…In adult males, acute nicotine administration resulted in decreased intromission frequency, though this occurred only at 1.6 mg/kg, the highest dose tested (Retana-Marquez et al, 1993). Decreased sexual performance was also self reported in men exposed to cigarette smoke (Weisberg, 1985).…”

Section: Brain Effects Of Nicotine: Similarities and Differences Withmentioning

confidence: 96%

Potential Contribution of Aromatase Inhibition to the Effects of Nicotine and Related Compounds on the Brain

Biegon¹,

Alia‐Klein²,

Fowler³

2012

Front. Pharmacol.

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Cigarette smoking continues to be a major public health problem, and while smoking rates in men have shown some decrease over the last few decades, smoking rates among girls and young women are increasing. Practically all of the important aspects of cigarette smoking and many effects of nicotine are sexually dimorphic (reviewed by Pogun and Yararbas, 2009). Women become addicted more easily than men, while finding it harder to quit. Nicotine replacement appears to be less effective in women. This may be linked to the observation that women are more sensitive than men to non-nicotine cues or ingredients in cigarettes. The reasons for these sex differences are mostly unknown. Several lines of evidence suggest that many of the reported sex differences related to cigarette smoking may stem from the inhibitory effects of nicotine and other tobacco alkaloids on estrogen synthesis via the enzyme aromatase (cyp19a gene product). Aromatase is the last enzyme in estrogen biosynthesis, catalyzing the conversion of androgens to estrogens. This review provides a summary of experimental evidence supporting brain aromatase as a potential mediator and/or modulator of nicotine actions in the brain, contributing to sex differences in smoking behavior. Additional research on the interaction between tobacco smoke, nicotine, and aromatase may help devise new, sex specific methods for prevention and treatment of smoking addiction.

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“…The drug is used to treat urinary retention and other disorders. Several studies have demonstrated that muscarinic receptor agonists decrease the ejaculation latency of male rat sexual behavior (130-134), while muscarinic antagonist’s administration produced a dose-dependent increase in ejaculation latency (131). Additionally, it has been suggested that an imbalance between cholinergic and adrenergic function may be responsible for the tricyclic antidepressant-induced orgasmic dysfunction (135).…”

Section: Bethanecholmentioning

confidence: 99%

The drug treatment of delayed ejaculation

Abdel‐Hamid¹,

Elsaied²,

Mostafa³

2016

Transl. Androl. Urol.

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Delayed ejaculation (DE) is an uncommon and a challenging disorder to treat. It is often quite concerning to patients and it can affect psychosocial well-being. Here we reviewed how DE is treated pharmacologically .We also highlighted specific settings where drugs could be introduced to medical practice. Electronic databases were searched from 1966 to February 2016, including PubMed MEDLINE, EMBASE, EBCSO Academic Search Complete, Cochrane Systematic Reviews Database, and Google Scholar using key words; delayed ejaculation, retarded ejaculation, inhibited ejaculation, drugs, treatment, or pharmacology. To achieve the maximum sensitivity of the search strategy and to identify all studies, we combined “delayed ejaculation” as Medical Subject Headings (MeSH) terms or keywords with each of “testosterone” or “cabergoline” or “bupropion” or “amantadine” or “cyproheptadine” or “midodrine” or “imipramine” or “ephedrine” or “pseudoephedrine” or “yohimbine” or “buspirone” or “oxytocin” or “bethanechol” as MeSH terms or keywords. There are a number of drugs to treat patients with DE including: testosterone, cabergoline, bupropion, amantadine, cyproheptadine, midodrine, imipramine, ephedrine, pseudoephedrine, yohimbine, buspirone, oxytocin, and bethanechol. Although there are many pharmacological treatment options, the evidence is still limited to small trials, case series or case reports. Review of literature showed that evidence level 1 (Double blind randomized clinical trial) studies were performed with testosterone, oxytocin, buspirone or bethanechol treatment. It is concluded that successful drug treatment of DE is still in its infancy. The clinicians need to be aware of the pathogenesis of DE and the pharmacological basis underlying the use of different drugs to extend better care for these patients. Various drugs are available to address such problem, however their evidence of efficacy is still limited and their choice needs to be individualized to each specific case.

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Muscarinic and nicotinic influences on masculine sexual behavior in rats: Effects of oxotremorine, scopolamine, and nicotine

Cited by 22 publications

References 16 publications

Effects of gonadectomy and androgen supplementation on attention in male rats

Effects of gonadectomy and androgen supplementation on attention in male rats

Potential Contribution of Aromatase Inhibition to the Effects of Nicotine and Related Compounds on the Brain

The drug treatment of delayed ejaculation

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