Muscarinic receptors are involved in LMM3 tumor cells proliferation and angiogenesis

Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia

“…Whereas work from our [19] and other groups [2-4,7,8] provide strong evidence that M3R acts as a tumor promoter, the present observations newly suggest that in the colon M1R acts as a tumor suppressor. This putative role for M1R is unmasked by combined M1R and M3R deficiency in dual KO mice where tumor formation is similar to that observed in WT mice.…”

“…Activation of muscarinic receptors and downstream signaling was shown to stimulate proliferation of cells derived from lung [1,2], breast [3,4], prostate [5], colon [6,7], and skin [8] cancers, and muscarinic receptors are frequently over-expressed in these common cancers [9]. Hence, it is highly likely that activation of muscarinic receptor signaling plays a fundamentally important role in neoplastic transformation and progression.…”

Constitutively Active Soluble Form of Erythropoietin Receptor Suppresses Growth and Angiogenesis of Xenografts of Transfected Cancer Cell Lines

“…Recently chronic stress and other behavioral conditions have been reported to cause promotion and progression of cancers; catecholamines in ovarian cancers [21,22], muscarinic cholinergic receptors in prostate [23], colon [24], mammary carcinoma cells [25,26], and the receptors and ligands in small cell lung carcinoma [27,28] were shown to promote their growth and angiogenesis.…”

Muscarinic receptors autoantibodies purified from mammary adenocarcinoma-bearing mice sera stimulate tumor progression

“…Effects on VEGF-A production via mAchR activation induced by LTB-IgG could be also representing the promotion of tumor growth by cytokines and/or growth factors produced by collaborative actions between tumor and stroma. As we had previously reported mAchR activation by CARB triggered neoangiogenesis not only in the metastatic LMM3 tumor cells but also in macrophages purified from LMM3 tumor bearers pointing to a stimulatory pathway via parasympathetic nervous system during tumor progression [21,22].…”