2020
DOI: 10.1016/j.neuropharm.2019.107796
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Muscimol injection into the substantia nigra but not globus pallidus affects prepulse inhibition and startle reflex.

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Cited by 4 publications
(8 citation statements)
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“…To our surprise, quinpirole infusion was without effect on social behavior when infused in either the submissive or dominant partner. We have previously reported that intra-NAc infusion of quinpirole, at the same dose and volume used in the present study, impairs prepulse inhibition of the acoustic startle response in macaques (Waguespack et al, 2023). Moreover, while quinpirole did not modulate social behavior in the present study, it did increase self-directed behaviors in submissive subjects (p=0.019), as well as manipulation of cage objects when collapsed across dominance status (p=0.039).…”
Section: Discussionsupporting
confidence: 42%
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“…To our surprise, quinpirole infusion was without effect on social behavior when infused in either the submissive or dominant partner. We have previously reported that intra-NAc infusion of quinpirole, at the same dose and volume used in the present study, impairs prepulse inhibition of the acoustic startle response in macaques (Waguespack et al, 2023). Moreover, while quinpirole did not modulate social behavior in the present study, it did increase self-directed behaviors in submissive subjects (p=0.019), as well as manipulation of cage objects when collapsed across dominance status (p=0.039).…”
Section: Discussionsupporting
confidence: 42%
“…Despite the central role that the NAc plays in reward processing, and despite mounting evidence from rodent studies, the role of the NAc in social behavior in the non-human primate brain has been essentially unstudied. Given the many differences we and others have observed with respect to the impact of brain manipulations on behavior between rodents and primates (DesJardin et al, 2013;Dybdal et al, 2013;Aguilar et al, 2018;Waguespack et al, 2023), cross species comparisons are both warranted and sometimes surprising. While our findings with muscimol infusion were in the present study were generally consistent with the effects reported in rodents, much to our surprise, quinpirole infusion was entirely without effect on social behavior.…”
Section: Discussionmentioning
confidence: 97%
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“…Since in the present work the reduction of NAc activity was associated with an overall increase in VP activity, and the VP has an inhibitory connection with PPTg, the impact of dopaminergic transmission and NAc activity depends on the VP activation. It is interesting to note that there is a convergence of inputs from both ventral and dorsal striatum to PPTg that modulates PPI [73][74][75]. As implemented in the present model, the NAc controls the PPI tonus.…”
Section: Discussionmentioning
confidence: 80%
“…Since both NAc and VP are connected with PPTg, they form a bridge between cortical regions with the PPI pathway. However, studies with rats also found that the dorsal striatum and the dopaminergic transmission from substantia nigra also modulates the PPI by their connections with VP [73,76]. Disruption in striatal function could also lead to deficits in PPI by affecting the NAc-and VP-PPTg connections.…”
Section: Discussionmentioning
confidence: 99%