Muscimol state-dependent memory: Involvement of dorsal hippocampal μ-opioid receptors

Jafari‐Sabet, Majid; Jannat-Dastjerdi, Iman

doi:10.1016/j.bbr.2009.03.010

Cited by 27 publications

(26 citation statements)

References 75 publications

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“…These results are in agreement with our previous study (Jafari-Sabet and Jannat-Dastjerdi, 2009) and other investigators who found that muscimol impaired memory formation (Jerusalinsky et al, 1994;Castellano et al, 1996;Farr et al, 2000;Chapouthier, 2004;Amaral et al, 2007), indicating the possible existence of an inhibitory influence of the brain GABA-A system on memory.…”

Section: Discussionsupporting

confidence: 95%

“…Our previous study have shown that pre-training intra-dorsal hippocampal (intra-CA1) administration of the GABA-A receptor agonist, muscimol induced memory impairment which was restored when the same dose of the drug was administered 24 h later in a pre-test session (Jafari-Sabet and Jannat-Dastjerdi, 2009). This phenomenon has been named state-dependent learning (Izquierdo, 1980;Jafari-Sabet et al, 2005;Zarrindast et al, 2006).…”

Section: Introductionmentioning

confidence: 97%

“…These state-dependent effects are time-and dose-dependent and may be prevented or enhanced by activation of the dorsal hippocampal systems (Jafari-Sabet et al, 2005;Rezayof et al, 2008;Jafari-Sabet and Jannat-Dastjerdi, 2009). …”

Section: Introductionmentioning

confidence: 97%

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Involvement of dorsal hippocampal muscarinic cholinergic receptors on muscimol state-dependent memory of passive avoidance in mice

Jafari‐Sabet

2011

Life Sciences

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Section: Discussionsupporting

confidence: 95%

Section: Introductionmentioning

confidence: 97%

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Involvement of dorsal hippocampal muscarinic cholinergic receptors on muscimol state-dependent memory of passive avoidance in mice

Jafari‐Sabet

2011

Life Sciences

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“…Classically, state-dependent memory has been evaluated with the pre-or post-acquisition injection of different pharmacological agents and, posteriorly, with the pre-test administration of the same drug (Khavandgar et al 2002;Homayoun et al 2003;Rezayof et al 2008;Jafari-Sabet and Jannat-Dastjerdi 2009;Sanday et al 2012). It is well known that either post-training (Zarrindast et al 2007) or pre-test (Colpaert et al 2001) injection of morphine impairs memory.…”

Section: Cfcmentioning

confidence: 99%

Reconsolidation may incorporate state-dependency into previously consolidated memories

et al. 2013

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Some memories enter into a labile state after retrieval, requiring reconsolidation in order to persist. One functional role of memory reconsolidation is the updating of existing memories. There are reports suggesting that reconsolidation can be modulated by a particular endogenous process taking place concomitantly to its natural course, such as water or sleep deprivation. Here, we investigated whether an endogenous process activated during a natural/physiological experience, or a pharmacological intervention, can also contribute to memory content updating. Using the contextual fear conditioning paradigm in rats, we found that the endogenous content of an aversive memory can be updated during its reconsolidation incorporating consequences of natural events such as water deprivation, transforming a previously stored memory into a state-dependent one. This updating seems to be mediated by the activation of angiotensin AT1 receptors in the dorsal hippocampus and local infusion of human angiotensin II (ANGII) was shown to mimic the water deprivation effects on memory reconsolidation. Systemic morphine injection was also able to turn a previously acquired experience into a state-dependent memory, reproducing the very same effects obtained by water deprivation or local angiotensin II infusion, and suggesting that other state-dependent-inducing protocols would also be able to contribute to memory updating. These findings trigger new insights about the influence of ordinary daily life events upon memory in its continuing reconstruction, adding the realm of reconsolidation to the classical view of endogenous modulation of consolidation.

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“…Many clinical and experimental studies have shown that opioidergic agents such as tramadol affect learning and memory processes (Jafari-Sabet and Jannat-Dastjerdi, 2009;Chavant et al, 2011). Considerable evidence has shown that tramadol exerts its action through both opioid and nonopioid pathways.…”

Section: Introductionmentioning

confidence: 99%

Tramadol state-dependent memory: involvement of dorsal hippocampal muscarinic acetylcholine receptors

Jafari‐Sabet

Jafari-Sabet²,

Dizaji-Ghadim³

2016

Behavioural Pharmacology

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The effects on tramadol state-dependent memory of bilateral intradorsal hippocampal (intra-CA1) injections of physostigmine, an acetylcholinesterase inhibitor, and atropine, a muscarinic acetylcholine receptor antagonist, were examined in adult male NMRI mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention. Post-training intra-CA1 administration of an atypical μ-opioid receptor agonist, tramadol (0.5 and 1 μg/mouse), dose dependently impaired memory retention. Pretest injection of tramadol (0.5 and 1 μg/mouse, intra-CA1) induced state-dependent retrieval of the memory acquired under the influence of post-training tramadol (1 μg/mouse, intra-CA1). A pretest intra-CA1 injection of physostigmine (1 μg/mouse) reversed the memory impairment induced by post-training administration of tramadol (1 μg/mouse, intra-CA1). Moreover, pretest administration of physostigmine (0.5 and 1 μg/mouse, intra-CA1) with an ineffective dose of tramadol (0.25 μg/mouse, intra-CA1) also significantly restored retrieval. Pretest administration of physostigmine (0.25, 0.5, and 1 μg/mouse, intra-CA1) by itself did not affect memory retention. A pretest intra-CA1 injection of the atropine (1 and 2 μg/mouse) 5 min before the administration of tramadol (1 μg/mouse, intra-CA1) dose dependently inhibited tramadol state-dependent memory. Pretest administration of atropine (0.5, 1, and 2 μg/mouse, intra-CA1) by itself did not affect memory retention. It can be concluded that dorsal hippocampal muscarinic acetylcholine receptor mechanisms play an important role in the modulation of tramadol state-dependent memory.

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Muscimol state-dependent memory: Involvement of dorsal hippocampal μ-opioid receptors

Cited by 27 publications

References 75 publications

Involvement of dorsal hippocampal muscarinic cholinergic receptors on muscimol state-dependent memory of passive avoidance in mice

Involvement of dorsal hippocampal muscarinic cholinergic receptors on muscimol state-dependent memory of passive avoidance in mice

Reconsolidation may incorporate state-dependency into previously consolidated memories

Tramadol state-dependent memory: involvement of dorsal hippocampal muscarinic acetylcholine receptors

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