Background: As the sustainability of the agricultural workforce has been threatened by the high prevalence of back pain, developing effective interventions to reduce its burden within farming will contribute to the long-term health and productivity of workers. Passive back-support exoskeletons are being explored as an intervention to reduce the physical demands on the back muscles, and consequently mitigate the risk of back pain, in many industrial sectors. Methods: This study investigated whether exoskeleton use could reduce farmers' low back muscle load. Electromyography was used to evaluate exoskeleton use in field and laboratory settings. A total of 14 farmers (13 males and 1 female) with a mean age of 49 (SD = 12) years and 6 female nonfarmers (mean age 28, SD = 5 years) performed a standardized set of tasks that included symmetric and asymmetric lifting and sustained trunk flexion. Following the standardized tasks, 14 farmers also performed regular, real-world, farm tasks with and without use of the exoskeleton at their farms. Results: Exoskeleton use decreased back muscular load during farming activities up to 65%, 56%, and 48% in static, median, and peak muscle activity, respectively. This indicates potential benefits of exoskeleton use to help farmers work under less muscular load. Paradoxically, exoskeleton use during standardized tasks increased muscle activity for some participants. Conclusions: This study demonstrates the potential effects of using passive exoskeletons in agriculture through observational and experimental research, and is among the first that explores the potential for using exoskeletons during actual work tasks in farm settings. K E Y W O R D S agriculture, back, electromyography, exoskeleton 1 | INTRODUCTION Globally, musculoskeletal disorders (MSDs) are one of the leading causes of disability. In 2017 the 1-year prevalence of MSDs was 17% worldwide and 22% in Canada, and the 1-year prevalence of back pain was 7.5% worldwide and 13% in Canada. 1 MSDs are more prevalent in farmers than nonfarmers in the rural workforce, with the low back being the most commonly affected body region. 2 Previous research on US farmers involved in highly mechanized prairie agriculture demonstrated twice the risk of back pain compared to