Muscle-afferent projection to the sensorimotor cortex after voluntary movement and motor-point stimulation: An MEG study

Onishi, Hideaki; Oyama, Masanobu; Soma, Takako; Kirimoto, Hikari; Sugawara, Kazuhiro; Murakami, Hiroatsu; Kameyama, Shigeki

doi:10.1016/j.clinph.2010.07.027

Cited by 15 publications

(9 citation statements)

References 45 publications

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“…Additionally, several studies reported that muscle afferent inputs also reach M1 (Lucier et al, 1975; Zarzecki et al, 1978). Multiple cortical imaging techniques, including magnetoencephalography, functional MRI and positron emission tomography, have shown that electrical stimulation without muscle contraction and mechanical tactile stimulation to the index finger predominantly activates S1 (Xiang et al, 1997; Terumitsu et al, 2009), whereas motor-point stimulation with contraction of the extensor indicis muscle or passive finger movement activates both M1 and S1 (Weiller et al, 1996; Xiang et al, 1997; Nelles et al, 1999; Radovanovic et al, 2002; Terumitsu et al, 2009; Onishi et al, 2011, 2013). These results provide evidence that different brain regions are activated by mixed nerve stimulation with muscle contraction and sensory nerve stimulation to the index finger without muscle contraction.…”

Section: Discussionmentioning

confidence: 99%

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Sasaki

Kotan

Nakagawa

et al. 2017

Front. Hum. Neurosci.

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Modulation of cortical excitability by sensory inputs is a critical component of sensorimotor integration. Sensory afferents, including muscle and joint afferents, to somatosensory cortex (S1) modulate primary motor cortex (M1) excitability, but the effects of muscle and joint afferents specifically activated by muscle contraction are unknown. We compared motor evoked potentials (MEPs) following median nerve stimulation (MNS) above and below the contraction threshold based on the persistence of M-waves. Peripheral nerve electrical stimulation (PES) conditions, including right MNS at the wrist at 110% motor threshold (MT; 110% MNS condition), right MNS at the index finger (sensory digit nerve stimulation [DNS]) with stimulus intensity approximately 110% MNS (DNS condition), and right MNS at the wrist at 90% MT (90% MNS condition) were applied. PES was administered in a 4 s ON and 6 s OFF cycle for 20 min at 30 Hz. In Experiment 1 (n = 15), MEPs were recorded from the right abductor pollicis brevis (APB) before (baseline) and after PES. In Experiment 2 (n = 15), M- and F-waves were recorded from the right APB. Stimulation at 110% MNS at the wrist evoking muscle contraction increased MEP amplitudes after PES compared with those at baseline, whereas DNS at the index finger and 90% MNS at the wrist not evoking muscle contraction decreased MEP amplitudes after PES. M- and F-waves, which reflect spinal cord or muscular and neuromuscular junctions, did not change following PES. These results suggest that muscle contraction and concomitant muscle/joint afferent inputs specifically enhance M1 excitability.

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Section: Discussionmentioning

confidence: 99%

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Sasaki

Kotan

Nakagawa

et al. 2017

Front. Hum. Neurosci.

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“…Among these components, 2M(P) and 3M(P) were the most notable and stable, but the initial component of 1M(P) at around 20 ms had a small amplitude and was detected in only three of the ten subjects. Another SEF study related to proprioception reported responses over the contralateral hemisphere at 78.7 ms (M70) following motor-point electrical stimulation applied to the right extensor indicis muscles using a pair of wire electrodes (Onishi et al, 2011). The authors concluded that the M70 component, whose onset latency occurred approximately 40 ms after the motor-point stimulation, must not reflect the initial cortical response of proprioceptive afferents, since the initial proprioceptive response at the thalamus level after motor-point stimulation of the extensor digitorum muscles was confirmed to occur at 10-12 ms by direct recording (Fukuda et al, 2000).…”

Section: Conduction Time Of the Afferent Pathwaysmentioning

confidence: 99%

Cortico-muscular synchronization by proprioceptive afferents from the tongue muscles during isometric tongue protrusion

et al. 2016

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Tongue movements contribute to oral functions including swallowing, vocalizing, and breathing. Fine tongue movements are regulated through efferent and afferent connections between the cortex and tongue. It has been demonstrated that cortico-muscular coherence (CMC) is reflected at two frequency bands during isometric tongue protrusions: the beta (β) band at 15-35 Hz and the low-frequency band at 2-10 Hz. The CMC at the β band (β-CMC) reflects motor commands from the primary motor cortex (M1) to the tongue muscles through hypoglossal motoneuron pools. However, the generator mechanism of the CMC at the low-frequency band (low-CMC) remains unknown. Here, we evaluated the mechanism of low-CMC during isometric tongue protrusion using magnetoencephalography (MEG). Somatosensory evoked fields (SEFs) were also recorded following electrical tongue stimulation. Significant low-CMC and β-CMC were observed over both hemispheres for each side of the tongue.Time-domain analysis showed that the MEG signal followed the electromyography signal for low-CMC, which was contrary to the finding that the MEG signal preceded the electromyography signal for β-CMC. The mean conduction time from the tongue to the cortex was not significantly different between the low-CMC (mean, 80.9 ms) and SEFs (mean, 71.1 ms). The cortical sources of low-CMC were located significantly posterior (mean, 10.1 mm) to the sources of β-CMC in M1, but were in the same area as tongue SEFs in the primary somatosensory cortex (S1). These results reveal that the low-CMC may be driven by proprioceptive afferents from the tongue muscles to S1, and that the oscillatory interaction was derived from each side of the tongue to both hemispheres. Oscillatory proprioceptive feedback from the tongue muscles may aid in the coordination of sophisticated tongue movements in humans.

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“…ECDs, equivalent current dipoles; SMA, supplementary motor area; PPC, posterior parietal cortex; cS2, contralateral secondary somatosensory cortex. been reported that ECD of MEF1 located in the precentral area, regardless of MEF1 responses, is the result of afferent feedback from muscles (Woldag et al 2003;Onishi et al 2011). It is well known that the muscle afferents project to areas 3a and 2 (Jones 1983).…”

Section: Discussionmentioning

confidence: 99%

“…Neuromagnetic fields over the hemisphere contralateral to the side of the movement change immediately after voluntary movement and are known as movement-evoked magnetic fields (MEFs); these fields are proposed to reflect sensory feedback to the cortex from the periphery. The earliest of these magnetic fields, MEF1, occurs approximately 80-110 msec after the onset of electromyographic (EMG) activity or 20-40 msec after movement onset (Cheyne and Weinberg 1989;Cheyne et al 1991Cheyne et al , 1997Cheyne et al , 2006Kristeva-Feige et al 1994Nagamine et al 1994;Hoshiyama et al 1997a;Woldag et al 2003;Oishi et al 2004;Onishi et al 2006Onishi et al , 2011.…”

Section: Introductionmentioning

confidence: 99%

Neuromagnetic activation following active and passive finger movements

et al. 2013

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The detailed time courses of cortical activities and source localizations following passive finger movement were studied using whole-head magnetoencephalography (MEG). We recorded motor-related cortical magnetic fields following voluntary movement and somatosensory-evoked magnetic fields following passive movement (PM) in 13 volunteers. The most prominent movement-evoked magnetic field (MEF1) following active movement was obtained approximately 35.3 ± 8.4 msec after movement onset, and the equivalent current dipole (ECD) was estimated to be in the primary motor cortex (Brodmann area 4). Two peaks of MEG response associated with PM were recorded from 30 to 100 msec after movement onset. The earliest component (PM1) peaked at 36.2 ± 8.2 msec, and the second component (PM2) peaked at 86.1 ± 12.1 msec after movement onset. The peak latency and ECD localization of PM1, estimated to be in area 4, were the same as those of the most prominent MEF following active movement. ECDs of PM2 were estimated to be not only in area 4 but also in the supplementary motor area (SMA) and the posterior parietal cortex (PPC) over the hemisphere contralateral to the movement, and in the secondary somatosensory cortex (S2) of both hemispheres. The peak latency of each source activity was obtained at 54–109 msec in SMA, 64–114 msec in PPC, and 84–184 msec in the S2. Our results suggest that the magnetic waveforms at middle latency (50–100 msec) after PM are different from those after active movement and that these waveforms are generated by the activities of several cortical areas, that is, area 4 and SMA, PPC, and S2. In this study, the time courses of the activities in SMA, PPC, and S2 accompanying PM in humans were successfully recorded using MEG with a multiple dipole analysis system.

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Muscle-afferent projection to the sensorimotor cortex after voluntary movement and motor-point stimulation: An MEG study

Cited by 15 publications

References 45 publications

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability

Cortico-muscular synchronization by proprioceptive afferents from the tongue muscles during isometric tongue protrusion

Neuromagnetic activation following active and passive finger movements

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