Muscle and Serum Magnesium in Pulmonary Intensive Care Unit Patients

Fiaccadori, Enrico; Canale, S. Del; Coffrini, E.; Melej, R; Vitali, Pietro; Guariglia, A; Borghetti, A

doi:10.1097/00003246-198808000-00004

Cited by 87 publications

(49 citation statements)

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“…In contrast to the differences described in the level of skeletal muscle magnesium, the potassium level in skeletal muscle was not different in asthmatics compared with controls, which contrasts with the findings of FIACCADORI et al [25], who found lower muscle and intracellular potassium in patients with COPD admitted to the Intensive Care Unit.…”

Section: Discussioncontrasting

confidence: 99%

“…In a study on the bronchodilating effect of intravenous magnesium sulphate in six patients with acute severe asthma [4], both serum levels and intracellular concentrations (erythrocytes) of magnesium were within normal limits. An investigation in chronic obstructive pulmonary disease (COPD) patients admitted to the Intensive Care Unit [25] showed low muscle magnesium values in 15 (47%) of 32 patients but no alteration of serum magnesium levels. Serum magnesium falls in response to high catecholamine levels, for example in acute myocardial infarction, and it has also been shown to fall in patients receiving infused but not inhaled β 2 -agonists [19].…”

Section: Discussionmentioning

confidence: 99%

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Skeletal muscle magnesium and potassium in asthmatics treated with oral beta 2-agonists

Gustafson

Boman²,

Rosenhall³

et al. 1996

Eur Respir J

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Dietary magnesium has been shown to be important for lung function and bronchial reactivity. Interest in electrolytes in asthma has so far mainly been focused upon serum potassium, especially linked to β 2 -agonist treatment. It is known that serum levels of magnesium and potassium may not correctly reflect the intracellular status. We therefore investigated whether asthmatics treated with oral β 2 -agonists had low magnesium or potassium in skeletal muscle and serum, and whether withdrawal of the oral β 2 -agonists would improve the electrolyte levels.Magnesium and potassium levels in skeletal muscle biopsies, serum and urine were analysed in 20 asthmatics before and 2 months after withdrawal of long-term oral β 2 -agonists, and for comparison in 10 healthy subjects.Skeletal muscle magnesium in the asthmatics was lower both before (3.62±0.69 mmol·100 g -1 (mean±SD)) and after (3.43±0.60 mmol·100 g -1 ) withdrawal of oral β 2 -agonists compared with the controls (4.43±0.74 mmol·100 g -1 ). Skeletal muscle potassium and serum magnesium did not differ between the groups. Serum potassium was significantly lower both before (4.0±0.2 mmol·L -1 ) and after (3.9±0.2 mmol·L -1 ) the withdrawal of oral β 2 -agonists compared with the control group (4.2±0.2 mmol·L -1 ).The asthmatics had lower skeletal muscle magnesium and lower serum potassium than the healthy controls, both with and without oral β 2 -agonists. Whether the findings are related to asthma pathophysiology or treatment is currently being investigated.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Skeletal muscle magnesium and potassium in asthmatics treated with oral beta 2-agonists

Gustafson

Boman²,

Rosenhall³

et al. 1996

Eur Respir J

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“…In the conducted studies, hypomagnesemia varied from 9.4% in the severely ill patients due to chronic obstructive pulmonary disease (COPD) to 61% in patients who had undergone major surgeries (24,25). The risk of mortality in the patients admitted to ICU was 2 to 3 times higher in patients with hypomagnesaemia compared to the ones without hypomagnesaemia (4, 14, 18).…”

Section: Discussionmentioning

confidence: 99%

Magnesium Level Changes and its Possible Effects on the Outcome of Patients Admitted to Intensive Care Unit

et al. 2017

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“…Safavi et al 18 found also the longer duration of ventilatory assistance (7.2 vs 4.7 days, p value <0.01) in patients with low magnesium. Fiaccordori et al 21 observed that patients with low muscle magnesium were on ventilatory support for more number of days. Molloy et al 22 observed improvement of respiratory muscle weakness in hypomagnesaemic patients on administering magnesium in their study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hypomagnesemia and Its Predictive Prognostic Value in Critically Ill Medical Patients

Subhraprakashpramanik¹

2014

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(81.1% vs. 34.0%, p = <0.001), hypokalemia (81.1% vs. 51.1%, p = <0.001) and hyponatremia(62.3% vs. 40.4%, p = 0.029) in compared to patients with normal magnesium.Though associated the mortality did not correlated significantly sig. 0.710, with hypomagnesaemiain this study and the sepsis sig. 0.001,) and the maximum SOFA score sig. 0.001,) became evident as the strong predominant underlying factor for hypomagnesemia.

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Muscle and Serum Magnesium in Pulmonary Intensive Care Unit Patients

Cited by 87 publications

References 0 publications

Skeletal muscle magnesium and potassium in asthmatics treated with oral beta 2-agonists

Skeletal muscle magnesium and potassium in asthmatics treated with oral beta 2-agonists

Magnesium Level Changes and its Possible Effects on the Outcome of Patients Admitted to Intensive Care Unit

Prevalence of Hypomagnesemia and Its Predictive Prognostic Value in Critically Ill Medical Patients

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