Muscle blood flow in normal and hypertensive subjects

Améry, A; Bossaert, H; Verstraete, Marc

doi:10.1016/0002-8703(69)90010-6

Cited by 56 publications

(7 citation statements)

References 18 publications

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“…In the skeletal muscles the blood flow is increased in the early stage, and the total peripheral resistance is increased (Conway, 1963;Amery, Bossaert & Verstracle, 1969), but there is no correlation between central and peripheral haemodynamics (Fantini, Nuzzaci, Padeletti, Michelucci, Arcangeli & Forti, 1977).…”

Section: Regional Circulation At Restmentioning

confidence: 99%

Haemodynamics in Essential Hypertension

Lund‐Johansen

1980

Clinical Science

200

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Section: Regional Circulation At Restmentioning

confidence: 99%

Haemodynamics in Essential Hypertension

Lund‐Johansen

1980

Clinical Science

200

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“…HE CLINICAL observation that patients with critical limb ischemia tend to find relief in the sitting position and the need to identify conditions that might affect the already impaired tissue perfusion have stimulated research into the effect of postural alteration on lower limb arterial flow. Arteriovenous oxygen difference, 1 venous occlusion plethysmography, 2,3 xenon clearance, [4][5][6][7][8][9][10][11] and duplex ultrasonographic flowmetry 12 are among the methods that have been used by different investigators.…”

mentioning

confidence: 99%

“…It is maintained that blood flow in the lower extremities of normal subjects or patients with peripheral vascular disease (PVD) without critical limb ischemia decreases as body posture alters from recumbent to erect (and vice versa). 2,4,5,7,8,[12][13][14][15] This (venoarteriolar) response has been ascribed to the venoarteriolar reflex, 8,9,13,16 a local sympathetic reflex that causes the precapillary resistance to increase in response to elevation of venous pressure, thus decreasing capillary flow. 17,18 Whatever the mechanism of action, it is believed to function almost normally in patients with claudication but to be defective in patients with rest pain.…”

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confidence: 99%

Effect of Posture on Popliteal Artery Hemodynamics

Delis

Nicolaides²,

Stansby³

2000

Arch Surg

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Hypothesis: Marked peripheral vasodilation and rubor characterize critically ischemic limbs on dependency. We believe that intermittent claudication is also associated with peripheral hemodynamic changes on postural alteration, which differ distinctly from normal. Evaluation of such differences and understanding of the underlying physiological derangements may be essential in the development of treatments for intermittent claudication. We comparatively assess the effect of posture on lower limb arterial hemodynamics in normal subjects and in patients with intermittent claudication (or Fontaine II) due to peripheral vascular disease, determined in the popliteal artery. Design: A cohort study. Setting: A university-associated tertiary care hospital. Patients: Thirty-seven legs of 29 normal subjects (group A) and 50 legs of 36 patients with intermittent claudication (ankle-brachial index range, 0.39-0.76; median, 0.57) (group B). Interventions: Popliteal artery volume flow (vFl), mean velocity, and luminal diameter were measured on (1) recumbency, (2) sitting, and (3) return to recumbency in groups A and B using color duplex imaging. Main Outcome Measures: The pulsatility index, peak systolic velocity, and end diastolic velocity (EDV) were measured on (1) recumbency, (2) sitting, and (3) return to recumbency. Results: Popliteal artery vFl in normal subjects decreased from 110 ± 43 mL/min on recumbency to 57 ± 27 mL/min on sitting (PϽ.001) and returned to 111 ± 46 mL/ min on resumption of recumbency (PϽ.001). Similarly, in patients with intermittent claudication, vFl decreased from 113 ± 52 mL/min on recumbency to 76 ± 41 mL/min on sitting (PϽ.001) and increased on resumption of recumbency to 114 ± 53 mL/min (PϽ.001). There was no difference (P = .97) in the vFl between the study groups on recumbency, but sitting vFl in normal subjects was significantly lower than in patients with intermittent claudication (P = .04). The mean velocity, peak systolic velocity, and EDV displayed a similar pattern of change as vFl. The pulsatility index in both groups increased significantly on sitting (PϽ.001) and decreased on return to recumbency (PϽ.001). All data are given as mean ± SD. Conclusions: Lower limb arterial vFl, mean velocity, peak systolic velocity, and EDV decrease significantly (PϽ.001) when posture is altered from recumbency to sitting, in normal subjects and in patients with intermittent claudication. A decrease in the EDV and an increase in the pulsatility index on sitting indicate enhancement of arterial resistance to flow secondary to peripheral vasoconstriction. Quantitative differences between the groups in vFl (PϽ.04), EDV (PϽ.01), and pulsatility index (PϽ.001) on dependency indicate that the orthostatic vasoactive response in patients with intermittent claudication is significantly subdued, reflecting a marked derangement in venoarteriolar response.

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“…In fact, Costes et al 17 reported that muscle saturation and blood lactate levels during cycling exercise at mild-to-hard intensity improved following the induction of increased capillarisation and oxidative enzyme capacity with 4 weeks of endurance training, suggesting the adaptability of O 2 delivery to the O 2 demand. Furthermore, muscle O 2 saturation has been reported to be significantly lower in healthy older participants;18 moreover, in patients with heart failure, oxyHb/Mb has been demonstrated to be lower,19 along with reduced blood flow and limited O 2 delivery,20 21 as compared with younger and normal participants. These results indicate that a decrease in oxyHb/Mb levels is influenced by a restriction in O 2 delivery capacity.…”

Section: Discussionmentioning

confidence: 99%

Influence of muscle fibre composition on muscle oxygenation during maximal running

Machida

Naito

2015

BMJ Open Sport Exerc Med

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AimsTo investigate the relationship between muscle oxygenation (specifically, the levels of oxygenated haemoglobin and myoglobin [oxyHb/Mb]) during maximal running and muscle fibre composition, and to determine whether muscle fibre composition can be non-invasively estimated from oxyHb/Mb levels during maximal running.MethodsEight male runners (, 60.9± 4.6 mL·kg−1·min−1) performed an incremental running test on a treadmill. OxyHb/Mb levels of the vastus lateralis during maximal running were measured by near-infrared spectroscopy (NIRS). Muscle fibre composition of the vastus lateralis was determined from muscle biopsy samples from the same region measured by NIRS, and the fibre types were classified as type I, type IIa, or type IIb fibres using traditional pH-sensitive ATPase staining. Type I and type IIa fibres together were defined as oxidative fibres.ResultsOxyHb/Mb levels during running were lowest at exhaustion in all participants. OxyHb/Mb levels at exhaustion were positively correlated with the percentages of type I fibres (r=0.755, p<0.05) and oxidative fibres (r=0.944, p<0.01).ConclusionsWe conclude that higher oxyHb/Mb levels at exhaustion during maximal running are correlated with a higher percentage of oxidative fibres, indicating the potential importance of oxidative fibres in the maintenance of oxyHb/Mb levels during maximal running. Additionally, muscle fibre composition could be non-invasively estimated from oxyHb/Mb levels during maximal running tests in runners.

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Muscle blood flow in normal and hypertensive subjects

Cited by 56 publications

References 18 publications

Haemodynamics in Essential Hypertension

Haemodynamics in Essential Hypertension

Effect of Posture on Popliteal Artery Hemodynamics

Influence of muscle fibre composition on muscle oxygenation during maximal running

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