Muscle changes during reinnervation after repeated nerve injuries

Mira, Jean‐Claude

doi:10.1051/rnd:19820212

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…This would explain the greater density of type I fibers in the deeper zones in our earlier controls. After reinnervation, however, the initial muscle transformations are not stable as demonstrated here and elsewhere ( Mira, 1982 ; Bertelli et al, 1996 ) . In the present study, the later readjustment (i.e., increased density of type I fibers in deep zones) was correlated with functional grasping recovery.…”

Section: Discussionsupporting

confidence: 56%

“…In the present study, the initial mosaic arrangement of the muscle fiber types was never restored. The inability to reconstruct the initial mosaic pattern indicates the non‐specificity of muscle reinnervation in rats ( Buller et al, 1960 ; Karpati and Engel, 1968 ; Mira, 1982 ; Ijkema‐Paassen et al, 2002 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, type II motoneurons might be more easily misdirected or rather present an abortive elongation, never reaching the motor end plates. On the other hand, after median nerve crushing, functional recovery is complete ( Bertelli et al, 1998 ) , pathways are intact, reinnervation is specific ( Nguyen et al, 2002 ) , and there is no predominance of type I axons or type groupings ( Mira, 1982 ) . Collateral sprouting inside the muscle, thus, represents a stable compensatory mechanism for the deficient reinnervation following nerve grafting.…”

Section: Discussionmentioning

confidence: 99%

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The course of aberrant reinnervation following nerve repair with fresh or denatured muscle autografts

Bertelli

Taleb

Mira

et al. 2005

J Peripheral Nervous Sys

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Denatured muscle grafts obtained by freeze thawing have been proposed to replace losses in the peripheral nerves. In the present report, we compare the performance of such grafts with fresh grafts in the rat median nerve. A long-term effect of muscle interposition on reinnervation was studied by behavioral assessment, muscle ATPase histochemistry, and retrograde labeling of motoneurons. There was no difference in grasping strength recovery between fresh and denatured 10-mm-long muscle grafts. Recovery was delayed and incomplete. Twelve months after surgery, only 50% of the normal grasping strength was attained. Grasping recovery was not observed in the 20-mm-long graft groups. Pathway reinnervation was non-specific with a huge amount of motor fiber misdirection. A decrease in the number of misdirected motor fibers occurred with time and activity recovery. Muscle reinnervation was not specific with disturbance of the mosaic pattern and type-grouping formation. Preference of type I axons for reinnervating deeper zones was observed. Type I aberrant reinnervation was demonstrated in the muscle periphery. The mosaic distribution of type I and II muscle fibers was not stable, and readjustments were observed with time, correlating with grasping improvement. During grasping strength recovery, there was a decrease in the number of type I fibers peripherally located and an increase of those deeply disposed. A time- and activity-related recovery was associated with readjustment in the pathways and muscle fiber rearrangement. We suggest that muscle activity generates specificity.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The course of aberrant reinnervation following nerve repair with fresh or denatured muscle autografts

Bertelli

Taleb

Mira

et al. 2005

J Peripheral Nervous Sys

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Functional recovery improvement is related to aberrant reinnervation trimming. A comparative study using fresh or predegenerated nerve grafts

et al. 2006

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Experimentally predegenerated nerve grafts have been demonstrated to improve recovery. In a 12 month-long study, we compared the degree of recovery of conventional and predegenerated grafts in rat median nerve repair. To induce predegeneration the ulnar donor nerve was crushed and grafting to the median nerve was performed 2 weeks later. The day of recovery and the improvement of finger flexion strength were studied by the grasping test. At 3, 6, 9, and 12 months after surgery retrograde labeling studies and flexor carpi radialis muscle ATPase histochemistry were performed. In the predegenerated grafts, the recovery of finger flexion occurred 19.6+/-1.5 days after surgery and was significantly faster than that in the conventional group. Twelve months after surgery, a similar rate of 85% of grasping strength recovery in relation to the normal control rats was demonstrated for the conventional and predegenerated grafts. After grafting, a larger number of motoneurons, compared to the normal controls, were retrograde labeled in the median nerve. This surplus of retrograde labeled motoneurons in the predominantly sensory branch of the median nerve represented misdirected motor fibers. There was a time-related decrease in the number of labeled motoneurons, which correlated to functional grasping strength recovery. Muscle reinnervation induced a predominance of type I over type II muscle fibers. Forty percent of type I fibers were grouped indicating that collateral sprouting plays a prominent role during muscle reinnervation. Regeneration in predegenerated grafts was faster but the final rate of recovery was similar to conventional grafts.

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Effects of Repeated Denervation on Muscle Reinnervation

Mira

1984

Clinics in Plastic Surgery

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Muscle changes during reinnervation after repeated nerve injuries

Abstract: Introduction.

Cited by 3 publications

References 10 publications

The course of aberrant reinnervation following nerve repair with fresh or denatured muscle autografts

The course of aberrant reinnervation following nerve repair with fresh or denatured muscle autografts

Functional recovery improvement is related to aberrant reinnervation trimming. A comparative study using fresh or predegenerated nerve grafts

Effects of Repeated Denervation on Muscle Reinnervation

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