Muscle co-contraction patterns in robot-mediated force field learning to guide specific muscle group training

Pizzamiglio, Sara; Desowska, Adela; Shojaii, Pegah; Taga, Myriam; Turner, Duncan L.

doi:10.3233/nre-171453

Cited by 3 publications

(2 citation statements)

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“…Early motor adaptation was considered to reflect the early stage adaptation as these blocks encompassed the initial exposure to the forcefield and late motor adaptation to more adapted stages. Late wash out was included in the analysis to examine whether de-adaptation to the removed forcefield occurred and activity returned to baseline (Pizzamiglio et al ., 2017 ). To obtain sufficient trial counts for the ERP measures, the trials of each condition were pooled together and averaged in the following conditions, late familiarization, early and late motor adaptation, and late wash out, similar to the literature (Anguera et al ., 2009 ; Frank et al ., 2005 ; Pizzamiglio et al ., 2017 ).…”

Section: Methodsmentioning

confidence: 99%

“…TMS was applied to the contralateral (left) M1 cortex immediately before and after the motor adaptation condition, and EEG was acquired to measure cortical excitability linked to motor performance. Applying a highly standardized robot-mediated reaching task provides high measurement reliability and controllability in upper limb reaching tasks representing a highly standardized assessment of the motor system (Pizzamiglio et al ., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Motor adaptation and internal model formation in a robot-mediated forcefield

et al. 2021

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Background Motor adaptation relies on error-based learning for accurate movements in changing environments. However, the neurophysiological mechanisms driving individual differences in performance are unclear. Transcranial magnetic stimulation (TMS)-evoked potential can provide a direct measure of cortical excitability. Objective To investigate cortical excitability as a predictor of motor learning and motor adaptation in a robot-mediated forcefield. Methods A group of 15 right-handed healthy participants (mean age 23 years) performed a robot-mediated forcefield perturbation task. There were two conditions: unperturbed non-adaptation and perturbed adaptation. TMS was applied in the resting state at baseline and following motor adaptation over the contralateral primary motor cortex (left M1). Electroencephalographic (EEG) activity was continuously recorded, and cortical excitability was measured by TMS-evoked potential (TEP). Motor learning was quantified by the motor learning index. Results Larger error-related negativity (ERN) in fronto-central regions was associated with improved motor performance as measured by a reduction in trajectory errors. Baseline TEP N100 peak amplitude predicted motor learning (P = 0.005), which was significantly attenuated relative to baseline (P = 0.0018) following motor adaptation. Conclusions ERN reflected the formation of a predictive internal model adapted to the forcefield perturbation. Attenuation in TEP N100 amplitude reflected an increase in cortical excitability with motor adaptation reflecting neuroplastic changes in the sensorimotor cortex. TEP N100 is a potential biomarker for predicting the outcome in robot-mediated therapy and a mechanism to investigate psychomotor abnormalities in depression.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Motor adaptation and internal model formation in a robot-mediated forcefield

et al. 2021

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Quantifying residue-specific conformational dynamics of a highly reactive 29-mer peptide

Lindemann

Evans

Mijalis

et al. 2020

Sci Rep

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Understanding structural transitions within macromolecules remains an important challenge in biochemistry, with important implications for drug development and medicine. insight into molecular behavior often requires residue-specific dynamics measurement at micromolar concentrations. We studied MP01-Gen4, a library peptide selected to rapidly undergo bioconjugation, by using electron paramagnetic resonance (epR) to measure conformational dynamics. We mapped the dynamics of MP01-Gen4 with residue-specificity and identified the regions involved in a structural transformation related to the conjugation reaction. Upon reaction, the conformational dynamics of residues near the termini slow significantly more than central residues, indicating that the reaction induces a structural transition far from the reaction site. Arrhenius analysis demonstrates a nearly threefold decrease in the activation energy of conformational diffusion upon reaction (8.0 k B T to 3.4 k B T), which occurs across the entire peptide, independently of residue position. this novel approach to epR spectral analysis provides insight into the positional extent of disorder and the nature of the energy landscape of a highly reactive, intrinsically disordered library peptide before and after conjugation.

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Combined Effects and Timing of Robotic Training and Botulinum Toxin on Upper Limb Spasticity and Motor Function among individuals with post-stroke upper limb spasticity

Shin,

Park,

Kim

et al. 2024

Preprint

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Objective:This study aimed to evaluate the combined effects of robotic training (RT) and botulinum toxin (BTX) injections on motor function and spasticity in individuals with post-stroke upper limb spasticity (ULS). We also investigated the optimal timing of RT and BTX administration. Methods:Forty-two participants with chronic stroke-induced ULS were initially enrolled and randomized into four groups: Group A (RT+BTX at 4 weeks [W4]), Group B (RT+BTX at baseline [W0]), Group C (BTX at W0, RT at W4), and Group D (RT at W0, BTX at W4). Clinical assessments and robotic kinematic evaluations were conducted at W0, W4, and 8 weeks (W8). The primary outcome was the Fugl-Meyer Assessment (FMA) scores, and secondary outcomes included the modified Ashworth scale (MAS) of elbow and kinematic parameters such as spectral arc length mean speed, hand path ratio, and movement deviation in various movements. Results:Of the 42 participants, 40 completed the study. From W0 to W4, Group B showed the best results in terms of spasticity (MAS-elbow flexor and extensor) and kinematic variables, indicating that the combined use of BTX and RT is superior to sole interventions regarding motor function and spasticity. From W0 to W8, Group C demonstrated the most significant improvements in FMA scores and kinematic variables, indicating that the combined use of BTX and RT, especially when RT was initiated one month after BTX injection, resulted in superior functional outcomes compared to other timings of interventions. Conclusions: The combination of RT and BTX is more effective in enhancing motor function and reducing spasticity in individuals with ULS than either intervention alone or no intervention. Moreover, the timing of RT relative to BTX injection plays a crucial role in maximizing therapeutic benefits in stroke patients with ULS, considering the mode of action of each intervention. Trial registration: clinicaltrials.gov NCT02228863. Registered 23 Auguste 2014; retrospectively registered.

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Muscle co-contraction patterns in robot-mediated force field learning to guide specific muscle group training

Abstract: BACKGROUND: Muscle co-contraction is a strategy of increasing movement accuracy and

Cited by 3 publications

References 34 publications

Motor adaptation and internal model formation in a robot-mediated forcefield

Motor adaptation and internal model formation in a robot-mediated forcefield

Quantifying residue-specific conformational dynamics of a highly reactive 29-mer peptide

Combined Effects and Timing of Robotic Training and Botulinum Toxin on Upper Limb Spasticity and Motor Function among individuals with post-stroke upper limb spasticity

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