Muscle cramps — a mini review of possible causes and treatment options available with a special emphasis on diabetics — a narrative review

Roy, Sayak

doi:10.5603/dk.2019.0029

Cited by 3 publications

(3 citation statements)

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“… 66 Additionally, complications arising from diabetes mellitus, such as electrolyte imbalances, diabetic neuropathy, and vascular complications, are believed to play a significant role in the development of muscle cramps. 67 , 68 Research suggests that patient-centered symptom management strategies, including incremental dialysis, conservative care, exercise, or dietary modifications (eg, consuming spicy foods to stimulate oropharyngeal reflexes, leading to muscle relaxation), may help alleviate muscle spasms. 69 These findings point towards potential management strategies for DKD patients, emphasizing the importance of tailored approaches to symptom management.…”

Section: Discussionmentioning

confidence: 99%

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Exploring Symptom Clusters in Chinese Patients with Diabetic Kidney Disease: A Network Analysis

Duan,

Liu,

et al. 2024

IJGM

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The research on symptom management in patients with diabetic kidney disease (DKD) has shifted from separate symptoms to symptom clusters and networks recently. This study aimed to evaluate the unpleasant symptoms of DKD patients, and to investigate how these symptom clusters could affect patients. Methods: 408 DKD patients were recruited in this cross-sectional study. The symptoms of DKD patients were measured using the modified Dialysis Symptom Index. Network analysis was employed to evaluate the symptom network and the characteristics of individual nodes, while factor analysis was utilized to identify symptom clusters. Results: Blurred vision was the most prevalent symptom among DKD patients. The symptoms identified as the most distressing, severe, and frequent were light headache or dizziness, arteriovenous fistula/catheterization pain, and diarrhea, respectively. Five symptom clusters were obtained from factor analysis, and the most central symptom cluster in the entire symptom network was sexual dysfunction. Conclusion:This study identified five symptom clusters in Chinese DKD patients, with sexual dysfunction emerging as the most central cluster. These findings carry significant clinical implications, underscoring the necessity of assessing symptom clusters and their associations to enhance symptom management in DKD patients. Further research is essential to elucidate the underlying mechanisms of symptoms and to clarify the associations among symptoms in DKD patients across different disease trajectories or treatment modalities.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Exploring Symptom Clusters in Chinese Patients with Diabetic Kidney Disease: A Network Analysis

Duan,

Liu,

et al. 2024

IJGM

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“…It must be noted that "muscle cramps/myositis", and "low back pain (LBP)" symptoms have been reported in several ADs, including MS, RA, SLE, SS, and diabetes [350][351][352][353][354][355][356][357][358][359][360] with documented chronic latent T. gondii infection [98, 235,238,239]. Nb.…”

Section: T Gondii Infection and The Heart Muscle Cramps And Low Back ...mentioning

confidence: 99%

Solving the New Puzzle(s) 2014-2022: Flammer Syndrome Probably Represents a Mild Endophenotype of Raynaud’s Phenomenon Mainly Associated with Ocular Disturbances and Also Due to Latent T. gondii Infection

Prandota¹

2023

J Clin Med Cur Res

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negative effect on quality of life [9]. The study of 334 healthy subjects aged 50 years or elder in Japan showed that proportion of participants with increased sensitivity to cold widely ranged (6.1%-30.8% men, 14.3%-28.3% women) [12].In Eastern Asian populations CHHF occurs in 20%-52% of subjects [13][14][15], and ratio of men to women is 2:3 [16]. In Japan, this condition called "hiesho" is quite common involving over 60% of females, and in the latter stage of pregnancy "hiesho" manifests in about 40% of women, particularly in the advanced maternal age [17,18]. One study comparing Japanese with Brazilians reported that 57% of Brazilian pregnant women were aware of cold sensations [19,20]. CHHF is associated also with RP, gastric disturbances [21], as well as gynecological disorders, such as infertility and dysmenorrhea [22,23]. Nb. T. gondii infection causes ovarian dysfunction and disturbances in sperm motility, viability and concentration values, epididymis weight, and testicle inflammation [24][25][26][27][28].The presence of "hiesho" was found to be risk factor which can also lead to abnormal delivery because of weak labor pains, prolonged labor and atonic bleeding, premature delivery, amnion membrane rupture [17,29,30].In this context, it should be added that traditional Japanese fish dishes sushi and sashimi may, at least in part, play a role in development of these disorders [31], especially that wide distribution of T. gondii amongst sea fish and mammals may affect human health worldwide (e.g. the highest prevalence of the pathogen was found in otter (54.8%), and dolphin, whale and porpoise (30.92%) [32]. B. FS heritability.In Europe, most of FS symptoms appear in puberty and alleviate along with age, in women after menopause begun [33], albeit in the study of 3067 persons aged 65 years or elder 23.6% men and 28.6% women had cold extremities [34]. Importantly, parents of FS subjects also had similar symptoms which may suggest a heritability of this clinical entity [3,4]. Moreover, Konieczka & Erb [4] noted that there is a relationship between FS and RP, and suggested a genetic background of RP [35][36][37][38], but they believed that additional factor(s) may also play a role [4,35]. Nb. genetic factors appeared to be important in the development of RP as has been demonstrated in one familial and twin study [39]. FS often occurs in individuals who are slender, have a low blood pressure, are active, but also have unusually cold extremities, increased pain sensitivity, altered circadian rhythm, and prolonged falling asleep time [40,41]. C. Pathophysiological changes in FS.Individuals with FS have the autonomic nervous system imbalance with sympathetic predominance [4,42], lymphocytes and leukocytes in the eye have altered gene expression, and activated astrocytes in the retina also change their gene expression and morphology [2,[43][44][45], slightly increased plasma endothelin-1 (ET-1) levels, and increased systemic oxidative stress [5,46]. They also have enhanced sensitivity to some drugs, such as for ...

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Nocturnal Leg Cramps in Young Adults

Arshad,

Kanwal,

Ijaz

et al. 2023

PBMJ

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Nocturnal Leg cramps are painful, involuntary muscle spasms that occur in the legs while sleeping, most particularly in the calves. The soreness usually lasts less than five minutes and occurs before or immediately after you fall asleep. They most commonly affect the calf muscles but can also affect the foot and thighs. Leg cramps can affect anybody at any age, but as people become older, they become more common and often more severe. Objective: To study the prevalence and risk factors of nocturnal leg cramps in young adults in Punjab. Methods: This was an observational cross-sectional study; data were collected from cities of Punjab. 300 men and women of age 20 to 40 years were included who have nocturnal leg cramps. Results: The prevalence of nocturnal leg cramps was 47.3% according to this study. Nocturnal leg cramps are closely related to 3 to 4 hours of standing without changing body posture. Conclusions: Research demonstrates that teachers, workers, and medical professionals were more likely to experience nocturnal leg cramps. Prolonged standing and footwear were linked risk factors.

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Muscle cramps — a mini review of possible causes and treatment options available with a special emphasis on diabetics — a narrative review

Cited by 3 publications

References 50 publications

Exploring Symptom Clusters in Chinese Patients with Diabetic Kidney Disease: A Network Analysis

Exploring Symptom Clusters in Chinese Patients with Diabetic Kidney Disease: A Network Analysis

Solving the New Puzzle(s) 2014-2022: Flammer Syndrome Probably Represents a Mild Endophenotype of Raynaud’s Phenomenon Mainly Associated with Ocular Disturbances and Also Due to Latent T. gondii Infection

Nocturnal Leg Cramps in Young Adults

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