Muscle CT, biopsy and EMG in diagnosis of neuromuscular diseases

Gibertoni, Milena; Colombo, A; Schoenhuber, R; Galassi, Giuliana; Calò, Margherita; Crisi, Girolamo; Martinelli, C

doi:10.1007/bf02361435

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Reports of several studies have described a high concordance of needle EMG findings and muscle biopsy in identifying myopathy of various types, indicating that both techniques are useful and complement each other in the evaluation of myopathies . In these studies, the most frequently identified EMG abnormality was short‐duration, polyphasic MUP.…”

Section: Discussionmentioning

confidence: 94%

“…In the majority of myopathies, loss of muscle fibers, fiber size variation, and regeneration or reinnervation of fibers results in an alteration in the morphology of the MUPs, which become shorter in duration, lower in amplitude, and more polyphasic . However, these MUP changes are not specific for types of myopathies and have been described in inflammatory myopathies, muscular dystrophies, congenital myopathies, endocrine myopathies, and some metabolic myopathies . Pathologic changes of fiber necrosis and fiber splitting, with or without inflammatory invasion, may have the physiologic effect of separating entire or portions of muscle fibers from the end plate zone, resulting in a functionally denervated fiber and fibrillation potentials on needle EMG .…”

Section: Discussionmentioning

confidence: 99%

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Needle electromyography and histopathologic correlation in myopathies

et al. 2018

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Introduction: Needle electromyography (EMG) findings help confirm myopathy and may indicate specific pathologic changes on muscle biopsy. Methods: We conducted a retrospective chart review of 218 consecutive patients referred for muscle biopsy. Presence of specific needle EMG findings was correlated with pathologic findings of inflammation, necrosis, splitting, and vacuolar changes. Sensitivity, specificity, and positive and negative predictive values of specific EMG findings for pathologic changes were calculated. Results: Short-duration motor unit potentials (MUP) were sensitive (83%-94%) but not specific (34%-49%) for pathologic changes. Fibrillation potentials were 65%-74% sensitive and 58%-81% specific for inflammation, necrosis, splitting, or vacuolar changes. The absence of fibrillation potentials had high negative predictive value (82%-93%) for inflammation, splitting, or vacuolar changes. Discussion: Fibrillation potentials and short-duration MUPs predict pathologic changes of muscle fiber necrosis, splitting, and/or vacuolar changes (as seen with inflammatory myopathies and muscular dystrophies). Absence of fibrillation potentials suggests other myopathologic changes (e.g., congenital myopathy).

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Needle electromyography and histopathologic correlation in myopathies

et al. 2018

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Facial structure and functional findings in patients with progressive muscular dystrophy (Duchenne)

Eckardt

Harzer²

1996

American Journal of Orthodontics and Dentofacial Orthopedics

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Muscle biopsy practices in the evaluation of neuromuscular disease: A systematic literature review

Ross

McKelvie

Wong

et al. 2023

Neuropathology Appl Neurobio

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Aims Muscle biopsy techniques range from needle muscle biopsy (NMB) and conchotome biopsy to open surgical biopsy. It is unknown whether specific biopsy techniques offer superior diagnostic yield or differ in procedural complication rates. Therefore, we aimed to compare the diagnostic utility of NMB, conchotome and open muscle biopsies in the assessment of neuromuscular disorders. Methods A systematic literature review of the EMBASE and Medline (Ovid) databases was performed to identify original, full‐length research articles that described the muscle biopsy technique used to diagnose neuromuscular disease in both adult and paediatric patient populations. Studies of any design, excluding case reports, were eligible for inclusion. Data pertaining to biopsy technique, biopsy yield and procedural complications were extracted. Results Sixty‐four studies reporting the yield of a specific muscle biopsy technique and, or procedural complications were identified. Open surgical biopsies provided a larger tissue sample than any type of percutaneous muscle biopsy. Where anaesthetic details were reported, general anaesthesia was required in 60% of studies that reported open surgical biopsies. Percutaneous biopsies were most commonly performed under local anaesthesia and despite the smaller tissue yield, moderate‐ to large‐gauge needle and conchotome muscle biopsies had an equivalent diagnostic utility to that of open surgical muscle biopsy. All types of muscle biopsy procedures were well tolerated with few adverse events and no scarring complications were reported with percutaneous sampling. Conclusions When a histological diagnosis of myopathy is required, moderate‐ to large‐gauge NMB and the conchotome technique appear to have an equivalent diagnostic yield to that of an open surgical biopsy.

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Muscle CT, biopsy and EMG in diagnosis of neuromuscular diseases

Cited by 4 publications

References 8 publications

Needle electromyography and histopathologic correlation in myopathies

Needle electromyography and histopathologic correlation in myopathies

Facial structure and functional findings in patients with progressive muscular dystrophy (Duchenne)

Muscle biopsy practices in the evaluation of neuromuscular disease: A systematic literature review

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