Muscle Fat Fraction in Neuromuscular Disorders: Dual-Echo Dual-Flip-Angle Spoiled Gradient-Recalled MR Imaging Technique for Quantification—A Feasibility Study

Gaeta, Michele; Scribano, Emanuele; Mileto, Achille; Mazziotti, Silvio; Rodolico, Carmelo; Toscano, Antonio; Settineri, Nicola; Ascenti, Giorgio; Blandino, Alfredo

doi:10.1148/radiol.10101108

Cited by 81 publications

(80 citation statements)

References 32 publications

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“…It has been well documented that the amount of intramuscular fat is an accurate marker of disease progression [1], and it also sensitively correlates with both patient age and clinical stage [10][11][12][13][14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…with 10 years' experience in musculoskeletal radiology, according to the method described by Gaeta et al [16].…”

Section: Mr Image Analysis and Mff Calculationmentioning

confidence: 99%

“…Recently, Gaeta et al [16] found that MFF evaluation obtained with the dual-echo dual-flip angle SPGR MRI technique correlated well with histopathology in patients with neuromuscular disorders. The technique used by these authors is simple and available on every routine MRI system, and with a very short acquisition time.…”

Section: Introductionmentioning

confidence: 96%

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Muscle fat-fraction and mapping in Duchenne muscular dystrophy: evaluation of disease distribution and correlation with clinical assessments

et al. 2011

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Section: Discussionmentioning

confidence: 99%

“…with 10 years' experience in musculoskeletal radiology, according to the method described by Gaeta et al [16].…”

Section: Mr Image Analysis and Mff Calculationmentioning

confidence: 99%

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Muscle fat-fraction and mapping in Duchenne muscular dystrophy: evaluation of disease distribution and correlation with clinical assessments

et al. 2011

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“…9 Accordingly, Dixon MR imaging was used for evaluating muscle fat content in several clinical studies including patients with low back pain (LBP), 5,13 acute-to-chronic whiplash, 14 and neuromuscular disorders. 15 Quantification of degeneration (fat infiltration and atrophy) of lumbar paravertebral muscles has attracted interest in understanding their biologic influence on persistent LBP. Atrophy and fat infiltrates are identified in patients [16][17][18][19][20][21] and following experimentally induced lesions in a porcine model.…”

Section: 9mentioning

confidence: 99%

Age- and Level-Dependence of Fatty Infiltration in Lumbar Paravertebral Muscles of Healthy Volunteers

Crawford

Filli

Elliott

et al. 2015

AJNR Am J Neuroradiol

203

167

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“…13 Clinically, the magnitude and anatomical location of MFI alter the plan of care with respect to surgical management of rotator cuff tears. 11,12,16 Furthermore, measurement and histological confirmation of MFI with a quantitative MRI approach have been produced in both an animal 20 and human 10 model. This preliminary study aimed to establish the reliability of an MRI measure for mapping the magnitude and spatial distribution of MFI in the cervical multifidus and semispinalis cervicis muscles, and to provide preliminary data for comparing MFI in individuals with chronic WAD, individuals who have recovered from whiplash injury, and healthy controls.…”

Section: T T Conclusionmentioning

confidence: 99%

The Geography of Fatty Infiltrates Within the Cervical Multifidus and Semispinalis Cervicis in Individuals With Chronic Whiplash-Associated Disorders

Abbott¹,

Pedler²,

Sterling³

et al. 2015

J Orthop Sports Phys Ther

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Previous studies using magnetic resonance imaging (MRI) have revealed widespread fatty infiltrates in the neck extensor 5 and flexor 8 muscles of individuals with chronic whiplash-associated disorders (WADs). These high levels of muscle fat infiltration (MFI) were not present in those with chronic nontraumatic neck pain 6 or those without a history of neck disorders.5 While widespread, the greatest magnitude of MFI was consistently observed in the deepest muscular layer of the extensors (eg, the multifidus and semispinalis cervicis) when compared to the more superficial musculature (eg, semispinalis capitis, splenius capitis, and upper trapezius). 5,9The specific role of MFI in the development and maintenance of chronic WAD is not fully understood.7,24 Improvements in our mechanistic understanding of the development of structural changes (eg, composition and morphology) in the cervical muscles of patients with chronic WAD may shed light on their potential contribution to poor functional recovery. T T STUDY DESIGN:Cross-sectional. T T OBJECTIVES:To quantify the magnitude and distribution of muscle fat infiltration (MFI) within the cervical multifidus and semispinalis cervicis muscles in participants with chronic whiplashassociated disorders (WADs) compared to those who have fully recovered from a whiplash injury and healthy controls. T T BACKGROUND: Previous research has estab-lished the presence of increased MFI throughout the cervical extensor muscles of individuals with WAD when compared to healthy controls. These changes appear to be greater in the deepest muscles (eg, multifidus and semispinalis cervicis) than in the more superficial muscles. A detailed analysis of the distribution of MFI within these deep extensor muscles in chronic WAD, recovered, and control groups would provide a foundation for further investigation of specific mechanisms, etiologies, and targets for treatments. T T METHODS:Fifteen participants (WAD, n = 5; recovered, n = 5; and control, n = 5) were studied using a 3-D fat-water separation magnetic resonance imaging sequence. Bilateral measures of cervical multifidus and semispinalis cervicis MFI in 4 quartiles (1 [medial] to 4 [lateral]) at cervical levels C3 through C7 were included in the analysis. Intrarater and interrater reliability were established. A mixed-model analysis was performed to control for covariates, identify interaction effects, and compare MFI distribution between groups. T T RESULTS:The limits of agreement confirmed strong intrarater and interrater agreement at all levels (C3-C7). Sex, age, and body mass index were identified as significant covariates for MFI. Significant interactions were found between group and muscle quartile (P<.001) and between muscle quartile and cervical level (P<.001). Pairwise comparisons for intraquartile MFI between groups revealed significantly greater MFI in the WAD group when compared to the recovered group in the first quartile (P<.001), second quartile (P<.001), and third quartile (P = .03). When compared to the control group, the WA...

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Muscle Fat Fraction in Neuromuscular Disorders: Dual-Echo Dual-Flip-Angle Spoiled Gradient-Recalled MR Imaging Technique for Quantification—A Feasibility Study

Abstract: The results show that dual-echo dual-flip-angle SPGR MR imaging technique provides reliable calculation of MFF, consistent with biopsy measurements.

Cited by 81 publications

References 32 publications

Muscle fat-fraction and mapping in Duchenne muscular dystrophy: evaluation of disease distribution and correlation with clinical assessments

Muscle fat-fraction and mapping in Duchenne muscular dystrophy: evaluation of disease distribution and correlation with clinical assessments

Age- and Level-Dependence of Fatty Infiltration in Lumbar Paravertebral Muscles of Healthy Volunteers

The Geography of Fatty Infiltrates Within the Cervical Multifidus and Semispinalis Cervicis in Individuals With Chronic Whiplash-Associated Disorders

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