Muscle fatigue induced by stimulation with and without doublets

Bigland-Ritchie, B.; Zijdewind, Inge; Thomas, C. K.

doi:10.1002/1097-4598(200009)23:9<1348::aid-mus5>3.0.co;2-0

Cited by 69 publications

(72 citation statements)

References 20 publications

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“…This phenomenon is often called "muscle wisdom" (157,179). In addition, impulse trains in vivo typically begin with groups of closely spaced impulses (doublets), which appear to enable force production with less associated fatigue (54), likely because of the force potentiation occurring with the closely spaced impulses (1), which gives more effective force production for a given number of APs.…”

Section: Decreasing Firing Ratementioning

confidence: 99%

Skeletal Muscle Fatigue: Cellular Mechanisms

Allen¹,

Lamb²,

Westerblad³

2008

Physiological Reviews

1,898

1,876

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Repeated, intense use of muscles leads to a decline in performance known as muscle fatigue. Many muscle properties change during fatigue including the action potential, extracellular and intracellular ions, and many intracellular metabolites. A range of mechanisms have been identified that contribute to the decline of performance. The traditional explanation, accumulation of intracellular lactate and hydrogen ions causing impaired function of the contractile proteins, is probably of limited importance in mammals. Alternative explanations that will be considered are the effects of ionic changes on the action potential, failure of SR Ca2+ release by various mechanisms, and the effects of reactive oxygen species. Many different activities lead to fatigue, and an important challenge is to identify the various mechanisms that contribute under different circumstances. Most of the mechanistic studies of fatigue are on isolated animal tissues, and another major challenge is to use the knowledge generated in these studies to identify the mechanisms of fatigue in intact animals and particularly in human diseases.

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Section: Decreasing Firing Ratementioning

confidence: 99%

Skeletal Muscle Fatigue: Cellular Mechanisms

Allen¹,

Lamb²,

Westerblad³

2008

Physiological Reviews

1,898

1,876

View full text Add to dashboard Cite

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“…In terms of inferring the nature of the motor command, although the VAL technique has been shown to be a reliable technique to assess descending commands 40 and central fatigue 19,60 , this method presents some limitations. Indeed, some authors suggested that VAL overestimates maximal muscle activation [61][62][63] .…”

mentioning

confidence: 99%

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Rozand¹,

Grosprêtre²,

Stapley³

et al. 2015

JoVE

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Percutaneous electrical nerve stimulation is a non-invasive method commonly used to evaluate neuromuscular function from brain to muscle (supra-spinal, spinal and peripheral levels). The present protocol describes how this method can be used to stimulate the posterior tibial nerve that activates plantar flexor muscles. Percutaneous electrical nerve stimulation consists of inducing an electrical stimulus to a motor nerve to evoke a muscular response. Direct (M-wave) and/or indirect (H-reflex) electrophysiological responses can be recorded at rest using surface electromyography. Mechanical (twitch torque) responses can be quantified with a force/torque ergometer. M-wave and twitch torque reflect neuromuscular transmission and excitation-contraction coupling, whereas H-reflex provides an index of spinal excitability. EMG activity and mechanical (superimposed twitch) responses can also be recorded during maximal voluntary contractions to evaluate voluntary activation level. Percutaneous nerve stimulation provides an assessment of neuromuscular function in humans, and is highly beneficial especially for studies evaluating neuromuscular plasticity following acute (fatigue) or chronic (training/detraining) exercise. Video LinkThe video component of this article can be found at

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“…Muscle training can certainly help, but also has the potential for unwanted slowing [17]. Since both fatigue in the short term and slowing in the longer term is correlated to the number of pulses delivered to the neuromuscular system [21], [14], [28], [30], optimal patterns of stimulation have been investigated in a variety of applications with the aim of eliciting a desired force output with the minimum number of pulses [4], [12], [18], [20], [22], [3]. A possible approach to determine optimum patterns of stimulation is to maximize the force-time integral (FTI) per unit impulse (FTIpP) of the elicited isometric contractions.…”

mentioning

confidence: 99%

The optimal stimulation pattern for skeletal muscle is dependent on muscle length

Mela

Veltink

Huijing

et al. 2002

IEEE Trans. Neural Syst. Rehabil. Eng.

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Abstract-Stimulation patterns can be optimized by maximizing the force-time integral (FTI) per stimulation pulse of the elicited muscle contraction. Such patterns, providing the desired force output with the minimum number of pulses, may reduce muscle fatigue, which has been shown to correlate to the number of pulses delivered. Applications of electrical stimulation to use muscle as a controllable biological actuator may, therefore, be improved. Although muscle operates over a range of lengths, optimized patterns have been determined only at optimal muscle length. In this study, the patterns with up to four pulses that produced the highest isometric FTI were determined at 10 muscle lengths for 11 rabbit tibialis anterior muscles. The interpulse intervals (IPIs) used ranged from 4 to 54 ms. At high muscle length, the optimal stimulation pattern consisted of an initial short IPI (doublet) followed by longer IPIs, in agreement with previous studies. However, at low length, the third pulse still elicited more than linear summation (triplet); furthermore, the relative enhancement of the FTI per pulse was considerably larger at low length than at high length, suggesting that optimal stimulation patterns are length dependent.

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Muscle fatigue induced by stimulation with and without doublets

Cited by 69 publications

References 20 publications

Skeletal Muscle Fatigue: Cellular Mechanisms

Skeletal Muscle Fatigue: Cellular Mechanisms

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

The optimal stimulation pattern for skeletal muscle is dependent on muscle length

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