Muscle Function in Moderate to Severe Asthma: Association With Clinical Outcomes and Inflammatory Markers

Visser, Edith; Jong, Kim de; Zutphen, Tim van; Kerstjens, Huib A. M.; Brinke, Anneke ten

doi:10.1016/j.jaip.2022.12.043

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…In contrast, impaired muscle strength is associated with poor asthma control, impaired QoL, 38 and higher incidence of emergency department visits. 22 This finding indicates the differential roles of muscle mass and strength in asthma.…”

Section: Discussionmentioning

confidence: 91%

“… 5 A high fat mass index relative to free fat mass index and loss of muscle strength have also been reported to be associated with impaired AQLQ scores. 21 , 22 Furthermore, sarcopenia 23 and sarcopenic obesity, characterized by low muscle mass and high fat mass, were found to deteriorate activities of daily living. Studies have shown that the erector spinae and pectoral muscles serve as radiologic prognostic biomarkers in COPD, 9 , 12 which suggests that quantitative assessment of specific muscles may broaden our insight into asthma’s pathophysiology.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis

Shimizu,

Kimura,

Tanabe

et al. 2024

Journal of Allergy and Clinical Immunology: Global

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Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis

Shimizu,

Kimura,

Tanabe

et al. 2024

Journal of Allergy and Clinical Immunology: Global

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“…Subjects with asthma could develop diaphragmatic weakness or other respiratory muscle impairment related to decreased lung function. 37 Furthermore, dyslipidemia could be associated with an increased risk of asthma. 38 This may have resulted in overestimation of the effect of the apoB/apoA-I ratio on lung function.…”

Section: Discussionmentioning

confidence: 99%

Increased Apolipoprotein B/Apolipoprotein A-I Ratio Is Associated With Decline in Lung Function in Healthy Individuals: The Kangbuk Samsung Health Study

Lee,

Park,

Kwon

et al. 2024

J Korean Med Sci

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Background Lung dysfunction and high apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio are both recognized risk factors for cardiovascular disease. However, few studies have examined the association between the apoB/ApoA-I ratio and lung function. Therefore, we investigated whether this ratio is associated with decreased lung function in a large healthy cohort. Methods We performed a cohort study on 68,418 healthy Koreans (34,797 males, mean age: 38.1 years) who underwent a health examination in 2019. ApoB/apoA-I ratio was categorized into quartiles. Spirometric values at the fifth percentile in our population were considered the lower limit of normal (LLN), which was used to define lung function impairment. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs), using the lowest quartile as the reference, were estimated to determine lung function impairment. Results Mean apoB/apoA-I ratio was 0.67 ± 0.21. Subjects with the highest quartile of this ratio had the lowest predicted forced expiratory volume in one second (FEV 1 %) and forced vital capacity (FVC%) after controlling for covariates ( P < 0.001). However, FEV 1 /FVC ratio was not significantly different among the four quartiles ( P = 0.059). Compared with the lowest quartile (Q1, reference), the aORs (95% CI) for FEV 1 % < LLN across increasing quartiles (from Q2 to Q4) were 1.216 (1.094–1.351), 1.293 (1.156–1.448), and 1.481 (1.311–1.672) ( P for trend < 0.001), respectively. Similarly, the aORs for FVC% < LLN compared with the reference were 1.212 (1.090–1.348), 1.283 (1.147–1.436), and 1.502 (1.331–1.695) with increasing quartiles ( P for trend < 0.001). However, the aORs for FEV 1 /FVC < LLN were not significantly different among groups ( P for trend = 0.273). Conclusion High apoB/apoA-I ratio was associated with decreased lung function. However, longitudinal follow-up studies are required to validate our findings.

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Skeletal Muscle Weakness: A Novel Treatable Trait in Asthma?

Kankaanranta

Ilmarinen

2023

The Journal of Allergy and Clinical Immunology: In Practice

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Muscle Function in Moderate to Severe Asthma: Association With Clinical Outcomes and Inflammatory Markers

Cited by 6 publications

References 42 publications

Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis

Increased adiposity-to-muscle ratio and severity of sinusitis affect quality of life in asthma: Computed tomographic analysis

Increased Apolipoprotein B/Apolipoprotein A-I Ratio Is Associated With Decline in Lung Function in Healthy Individuals: The Kangbuk Samsung Health Study

Skeletal Muscle Weakness: A Novel Treatable Trait in Asthma?

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