Muscle function loss is associated with anxiety in patients with gastrointestinal cancer

Soares, Jéssika D.P.; Gomes, Tatyanne L.N.; Siqueira, Jéssika M.; Oliveira, Izabella C.L.; Mota, João Felipe; Laviano, Alessandro; Pimentel, Gustavo D.

doi:10.1016/j.clnesp.2018.11.003

Cited by 25 publications

(6 citation statements)

References 29 publications

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“…Participants with a history of upper gastrointestinal cancer were more likely to report experiencing depression or anxiety, and the odds of reporting anxiety and depression were 2.18 and 3.66 greater for those with upper gastrointestinal cancer compared to those with no cancer history. Upper gastrointestinal cancer survivors can experience physical symptoms, changes in eating behaviors, and physical functioning leading to appreciable impacts on quality of life [ 22 , 23 ], which in turn may increase risk of depression and anxiety [ 23 , 24 ]. However, due to small sample sizes in this diagnosis group, this result should be interpreted with caution and warrants further research.…”

Section: Discussionmentioning

confidence: 99%

Anxiety, depression, and concentration in cancer survivors: National Health and Nutrition Examination Survey results

Fardell

Irwin

Vardy

et al. 2023

Support Care Cancer

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Purpose We report on prevalence of anxiety, depression, and concentration difficulties and their associations in survivors of cancer in a nationally representative sample up to 25 years after diagnosis. Methods Using the National Health and Nutrition Examination Survey (NHANES) data from 2015 to 2018, participants between the ages of 18 and 79 self-reported on cancer history, symptoms of anxiety, depression, and difficulties with concentration. Results Of 10,337 participants, 691 (6.7%) reported a previous diagnosis of cancer; the median time since diagnosis was 8 years. Prevalence was similar between those with and without cancer for anxiety (45.8% versus 46.9%) and depression (19.7% versus 20.0%). Concentration difficulties were more common (11.3% versus 9.0%) for those with a history of cancer compared to those without (adjusted OR = 1.38, 95% CI: 1.00–1.90). Prevalence of mental health symptoms was not related to time since diagnosis. Anxiety and depression were highly correlated (r = 0.81, 95% CI: 0.74–0.86) and moderately correlated with difficulty with concentration (r = 0.52, 95%CI: 0.40–0.64 and r = 0.64, 95% CI: 0.53–0.74 respectively). Conclusions Difficulty with concentration was more commonly reported by participants with than without a cancer history. Report of anxiety and depression was no different between participants with and without a history of cancer. Anxiety, depression, and difficulties with concentration were strongly related. Further research is needed to explore if there is a causal association, and if so, the direction of these correlations, so that interventions may be appropriately targeted.

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Section: Discussionmentioning

confidence: 99%

Anxiety, depression, and concentration in cancer survivors: National Health and Nutrition Examination Survey results

Fardell

Irwin

Vardy

et al. 2023

Support Care Cancer

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“…Another study by Soares et al established SARC-F scores ≥4 in 25.4% of 71 patients with gastrointestinal cancer, which was associated with increased anxiety [8]. The same study found a lower mean BMI in the SARC-F score ≥ 4group.…”

Section: Discussionmentioning

confidence: 80%

“…Each question was scored from 0 to 2 points, resulting in a total score of 0-10 points (Table 1). Patients with a SARC-F score ≥4 were considered to be at risk of sarcopenia [3,8]. Patients' demographic data including age, gender, height, weight, body mass index (BMI), smoking, history of abdominal surgery, preoperative hemoglobin levels, site of operation and name of operation were recorded.…”

Section: Methodsmentioning

confidence: 99%

Interpretation of the SARC-F questionnaire in patients undergoing gastrointestinal cancer surgery

et al. 2021

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Sarcopenia is a skeletal muscle disorder associated with decreased muscle mass and functional capacity. The SARC-F questionnaire facilitates sarcopenia screening in elderly patients. The present study investigates the applicability of the SARC-F questionnaire to sarcopenia screening in patients scheduled for gastrointestinal cancer surgery and its relationship with postoperative outcomes.Material and methods: This cross-sectional study was carried out with elderly patients scheduled for gastrointestinal cancer surgery. The study included 71 patients consisting of 47 males and 24 females. The risk of sarcopenia was assessed by the Strength, Assistance with walking, Rising from a chair, Climbing stairs, and Falling (SARC-F) questionnaire. Patients with a SARC-F score ≥4 were considered to be at risk of sarcopenia. The demographic data, nutritional status and comorbidity data of the patients were recorded. Statistical analysis was conducted to assess postoperative complications in those patients at risk of sarcopenia.Results: The mean age of 71 study patients was 72.6±5.6 years. There were 15 (21.1%) patients with a SARC-F score ≥4. The postoperative complication rate was 60% in patients with a SARC-F score ≥4 in comparison with 28.5% of those with a SARC-F score <4, and the difference was statistically significant (p=0.024). The SARC-F score ≥4 group also had a longer hospital stay (p<0.001). Furthermore, the univariate analysis for postoperative complications revealed that SARC-F scores ≥4, age ≥75 years, and BMI ≥30 kg/m2 were statistically significant. Conclusion:We believe that the SARC-F questionnaire has a place in sarcopenia screening in patients scheduled for gastrointestinal surgery, and it is possible to predict postoperative adverse outcomes.

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“…Body mass index (BMI, kg/m 2 ) was calculated accordingly. Arm (mm) and calf (cm) circumferences were assessed using a flexible tape measure [10][11][12] .…”

Section: Methodsmentioning

confidence: 99%

High neutrophil to lymphocytes ratio is associated with nutritional risk in hospitalised, unselected cancer patients: a cross-sectional study

Siqueira

Soares

Borges

et al. 2021

Sci Rep

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Cancer patients possess metabolic and pathophysiological changes and an inflammatory environment that leads to malnutrition. This study aimed to (i) determine whether there is an association between neutrophil-to-lymphocyte ratio (NLR) and nutritional risk, and (ii) identify the cut-off value of NLR that best predicts malnutrition by screening for nutritional risk (NRS 2002). This cross-sectional study included 119 patients with unselected cancer undergoing chemotherapy and/or surgery. The NRS 2002 was applied within 24 h of hospitalisation to determine the nutritional risk. Systemic inflammation was assessed by blood collection, and data on C-reactive protein (CRP), neutrophils, and lymphocytes were collected for later calculation of NLR. A receiver operating characteristic (ROC) curve was used to identify the best cut-point for NLR value that predicted nutritional risk. Differences between the groups were tested using the Student’s t-, Mann–Whitney U and Chi-Square tests. Logistic regression analyses were performed to assess the association between NLR and nutritional risk. The ROC curve showed the best cut-point for predicting nutritional risk was NLR > 5.0 (sensitivity, 60.9%; specificity, 76.4%). The NLR ≥ 5.0 group had a higher prevalence of nutritional risk than the NLR < 5.0 group (NLR ≥ 5.0: 73.6% vs. NLR < 5.0: 37.9%, p = 0.001). The NLR group ≥ 5.0 showed higher values of CRP and NLR than the NLR < 5.0 group. In addition, patients with NLR ≥ 5.0 also had higher NRS 2002 values when compared to the NLR < 5.0 group (NLR ≥ 5.0: 3.0 ± 1.1 vs. NLR < 5.0: 2.3 ± 1.2, p = 0.0004). Logistic regression revealed an association between NRS and NLR values. In hospitalised unselected cancer patients, systemic inflammation measured by NLR was associated with nutritional risk. Therefore, we highlight the importance of measuring the NLR in clinical practice, with the aim to detect nutritional risk.

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Muscle function loss is associated with anxiety in patients with gastrointestinal cancer

Cited by 25 publications

References 29 publications

Anxiety, depression, and concentration in cancer survivors: National Health and Nutrition Examination Survey results

Anxiety, depression, and concentration in cancer survivors: National Health and Nutrition Examination Survey results

Interpretation of the SARC-F questionnaire in patients undergoing gastrointestinal cancer surgery

High neutrophil to lymphocytes ratio is associated with nutritional risk in hospitalised, unselected cancer patients: a cross-sectional study

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