Muscle-Invasive Bladder Cancer: Predictive Factors and Prognostic Difference Between Primary and Progressive Tumors

Türkölmez, Kadír; Tokgöz, Hüsnü; Reşorlu, Berkan; Köse, Kenan; Bedük, Yaşar

doi:10.1016/j.urology.2007.05.008

Cited by 61 publications

(45 citation statements)

References 19 publications

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“…143 The presence of lymphovascular invasion predicts poor outcome, and this finding should be included in the pathology report. [143][144][145][146][147] The 5-year cancer-specific survival was 87 and 65%, respectively, for those without and with lymphovascular invasion. 145 In another study of 283 radical cystectomy specimens, vascular invasion, pathological stage, and lymph node metastasis were independent predictors of cancer-specific survival.…”

Section: Lymphovascular Invasionmentioning

confidence: 99%

Staging and reporting of urothelial carcinoma of the urinary bladder

et al. 2009

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Section: Lymphovascular Invasionmentioning

confidence: 99%

Staging and reporting of urothelial carcinoma of the urinary bladder

et al. 2009

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“…However, the oncological outcome of de novo vs. progressive MIBC patients after RC remains inconsistent in the literature, with varying and sometimes even with contradictory results regarding survival. Several authors have reported either similar or insignificantly different and comparable survival rates between the 2 groups [4,5,6,7,8,9,10,11]. Others have reported better survival in patients who progressed after initial presentation as NMIBC [12,13,14,] while yet others have reported worse prognosis if RC is performed in patients who progress to MIBC after having NMBIC [15,16.…”

Section: Introductionmentioning

confidence: 99%

Survival after Radical Cystectomy for Bladder Cancer in Relation to Prior Non-Muscle Invasive Disease in Quebec

Zakaria

Santos²,

Kassouf³

et al. 2016

Urol Int

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Introduction and Objectives: The aim of this study was to assess if there is a difference in survival after radical cystectomy (RC) when examined in relation to prior non-muscle invasive bladder cancer (NMIBC) disease vs. invasive cancer de novo at time of diagnosis. Methods: We conducted a retrospective study of all patients who underwent RC within Quebec health insurance medical services database during the years (2000-2009). Overall survival (OS) outcome was assessed with Kaplan-Meier curves and hazard ratios (HRs) adjusted for age and gender. Results: A total of 2,671 subjects met the eligibility criteria. Among them, 19.8% had presumed prior NMIBC that further progressed to invasive disease. Median survival after RC for patients with presumed prior NMIBC was 4.3 years as compared to patients with presumed invasive disease de novo 3.7 years (p = 0.007, Wilcoxon test). Patients with presumed NMIBC at the time of diagnosis had a 16% decrease in the risk of mortality after RC, when compared to patients with presumed invasive BC de novo (HR 0.84, 95% CI 0.73-0.96 (p = 0.0166)). Conclusion: Our results suggest a slightly better prognosis, regarding OS after RC for patients with presumed NMIBC who progressed to invasive disease, when compared to patients with presumed invasive disease de novo at the time of diagnosis.

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“…Numerous studies have previously investigated potential prognostic factors for patients with bladder cancer, in order to guide therapeutic approaches and improve survival outcomes (15). Lymph node metastasis was previously identified as an important prognostic factor in patients with BTCC, since the survival rate of patients with lymph node metastasis of bladder cancer is usually low (16).…”

Section: Discussionmentioning

confidence: 99%

CCR7 as a predictive biomarker associated with computed tomography for the diagnosis of lymph node metastasis in bladder carcinoma

Chen

Liu

et al. 2015

Oncology Letters

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Abstract. The aim of the present study was to investigate whether the expression levels of CC-chemokine receptor 7 (CCR7) combined with computed tomography (CT) was associated with lymph node metastasis in bladder transitional cell carcinoma (BTCC). For this purpose, 115 cases of BTCC were analyzed at the Department of Urology of Xiangya Hospital, Central South University (Changsha, China). Preoperative CT scans of abdomen and pelvis, immunohistochemistry of CCR7 expression in the tumor specimens and pathological findings for lymph node metastasis were assessed. In addition, the sensitivity, specificity and accuracy of CCR7 and CT for the diagnosis of lymph node metastasis in BTCC were evaluated separately and jointly. The expression levels of CCR7 were observed to be significantly higher in BTCC than in normal controls (P<0.01). Multivariate analysis indicated that the overexpression of CCR7 was an independent predictor for lymph node metastasis in BTCC (P<0.05). The sensitivity, specificity and accuracy of CCR7 combined with CT scan for the diagnosis of lymph node metastasis in BTCC were 92.3, 83.6 and 70.0%, respectively. By contrast, the sensitivity, specificity and accuracy of CCR7 alone were 88.1, 69.9 and 76.5%, respectively, while the sensitivity, specificity and accuracy of CT alone were 52.4, 79.5 and 69.6%, respectively. The results of the present study indicated that CCR7 is an independent predictor of lymph node metastasis in BTCC. Therefore, the use of CCR7 combined with CT may improve the accuracy of the diagnosis of lymph node metastasis in BTCC.

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Muscle-Invasive Bladder Cancer: Predictive Factors and Prognostic Difference Between Primary and Progressive Tumors

Cited by 61 publications

References 19 publications

Staging and reporting of urothelial carcinoma of the urinary bladder

Staging and reporting of urothelial carcinoma of the urinary bladder

Survival after Radical Cystectomy for Bladder Cancer in Relation to Prior Non-Muscle Invasive Disease in Quebec

CCR7 as a predictive biomarker associated with computed tomography for the diagnosis of lymph node metastasis in bladder carcinoma

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